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The selection of solid particle and gas flow rate are among the governing parameters for high operating temperature and effective utilization of solar heat. DDR1IN1 The development of high temperature hybrid solar-biomass system is anticipated for higher solar-to-fuel conversion efficiencies, minimizing the direct combustion of biomass and reduce the emission of greenhouse gas (GHG) emissions.Due to their numerous effects on human health and the natural environment, water contamination with heavy metals and metalloids, caused by their extensive use in various technologies and industrial applications, continues to be a huge ecological issue that needs to be urgently tackled. Additionally, within the circular economy management framework, the recovery and recycling of metals-based waste as high value-added products (VAPs) is of great interest, owing to their high cost and the continuous depletion of their reserves and natural sources. This paper reviews the state-of-the-art technologies developed for the removal and recovery of metal pollutants from wastewater by providing an in-depth understanding of their remediation mechanisms, while analyzing and critically discussing the recent key advances regarding these treatment methods, their practical implementation and integration, as well as evaluating their advantages and remaining limitations. Herein, various treatment techniques are covered, including adsorption, reduction/oxidation, ion exchange, membrane separation technologies, solvents extraction, chemical precipitation/co-precipitation, coagulation-flocculation, flotation, and bioremediation. A particular emphasis is placed on full recovery of the captured metal pollutants in various reusable forms as metal-based VAPs, mainly as solid precipitates, which is a powerful tool that offers substantial enhancement of the remediation processes' sustainability and cost-effectiveness. At the end, we have identified some prospective research directions for future work on this topic, while presenting some recommendations that can promote sustainability and economic feasibility of the existing treatment technologies.Phthalate esters (PAEs) have known widely being used in plastic products leading to being ubiquitous in the environment by easy to release from those products. This study aims to understand the impact of heavy rainfall on the concentration of PAEs in surface sediments of the Salt River in Kaohsiung, Taiwan, and its potential ecological risks on aquatic organisms. The potential ecological risk assessment of sediment PAEs is based on the total risk quotient (TRQ) method. The total concentration of 10 PAEs (∑PAE10) in sediments of the Salt River is 333-13,615 ng/g dw, with an average of 4212 ± 3753 ng/g dw. Before the rainy season, the ∑PAE10 concentration in sediments at the outlets of domestic sewage in upstream was 9768-13,615 ng/g dw, which were relatively higher than other sites (542-3721 ng/g dw). During the rainy season, the ∑PAE10 concentration was 2820-12,041 ng/g dw, which was 1-11 times higher than that determined before the rainy season. After the rainy season, the ∑PAE10 concentration recorded was 530-6652 ng/g dw, which is 1-11 times lower than the value obtained during the rainy season. PAEs in sediments of the Salt River may have low to moderate potential risks to algae, crustaceans, and fish. Bis(2-ethylhexyl) phthalate (DEHP) and diisobutyl phthalate (DiBP) are the main PAE that poses a potential risk to algae and crustaceans, and to fish respectively, whose values of risk quotient accounts for 40-69% of the TRQ value. The distribution of TRQ values for these aquatic organisms show a decreasing trend of PAEs level with respect to the rainy season during the rainy season > after the rainy season > before the rainy season. Heavy rainfall may cause more serious pollution in sediments and increase the exposure risk of PAEs to aquatic organisms.Amongst the most important sustainable waste management strategies, anaerobic biotechnology has had a central role over the past century in the management of high-pollution load sources, such as food, agricultural and municipal wastes. During anaerobic digestion (AD), valuable by-products such as digestate and biogas are produced. Biogas (mainly composed of methane) is generated through a series of reactions between bacteria and archaea. Enhancement of AD process with higher methane yield, accelerated methane production rate, and shorter start-up time is possible via tapping into a novel methanogenic pathway discovered a decade ago. This fundamentally new concept that is a substitute to interspecies hydrogen transfer is called direct interspecies electron transfer (DIET). DIET, a thermodynamically more feasible way of electron transfer, has been proven to occur between bacteria and methanogens. It is well-documented that amendment of carbon-based conductive materials (CCMs) can stimulate DIET via serving as an electrical conduit between microorganisms. Therefore, different types of CCMs such as biochar and activated carbon have been amended to a variety of AD reactors and enhancement of process performance was reported. In this review, a comparative analysis is presented for enhancement of AD performance in relation to major CCM related factors; electrical conductivity, redox properties, particle size and dosage. Additionally, the impacts of AD operational conditions such as organic loading rate and temperature on CCM amended reactors were discussed. Further, the changes in microbial communities of CCM amended reactors were reviewed and future perspectives along with challenges for CCM application in AD have been provided.Although efficient improvement of the nitrogen removal from wastewater by adding iron was achieved in wastewater process, the influence mechanism of addition sites is unclear. The study was based on the A/O-MBR treating simulated domestic wastewater, and tea polyphenol-nano zero-valent iron/polyethylene packing (TP-NZVI/PE) was added into the anoxic tank, aerobic tank and membrane effluent end of the process, respectively. The effect of the different addition sites on the nitrogen removal performance of A/O-MBR was investigated. Combine with the corrosion rate of NZVI on the packing surface to optimize TP-NZVI/PE addition site. The enhancement mechanism of TP-NZVI/PE under different addition site was explored through the calculation of the materials balance (carbon, nitrogen, phosphorus). The results showed that the pollutant removal of A/O-MBR was significantly increased with the TP-NZVI/PE added. In particular, the TP-NZVI/PE was added into the aerobic tank, and the pollutant removal rate was increased 31.71% (TN) and 53.00% (total phosphorus), respectively. Meanwhile, the service life of TP-NZVI/PE in the aerobic tank was 66 days. The anti-oxidation and dispersion of NZVI was improved with the encapsulation of tea polyphenols and support of packing, and it also played a certain slow-release effect, so that the service life of NZVI was further prolonged in aerobic condition. Combined with the material balance analysis, the result showed that the environmental structure made diversity in the aerobic tank by added the TP-NZVI/PE, and the simultaneous nitrification and denitrification process was achieved. The dependence of the denitrification process on the carbon source was greatly reduced. Besides, it promoted the adsorption and chemical precipitation process of the system for phosphor pollutant and achieved the denitrifying phosphorus removal performance.

Incidence of colorectal cancer (CRC) in younger adults is increasing in many countries. Given the established association of body mass index (BMI) with CRC risk and the increasing obesity prevalence among younger generations, we aimed to evaluate the association of BMI at different ages during early adulthood with early-onset CRC.

Among 6602 patients with CRC and 7950 matched controls who were recruited in 2003-2020 in the Darmkrebs Chancen der Verhütung durch Screening study, a population-based case-control study from Germany, 747 patients and 621 controls were younger than 55 years and included in this analysis. Self-reported height and weight at ages 20 years and 30 years and at approximately 10 years before diagnosis or interview were recorded in personal interviews. Associations of BMI with early-onset CRC were estimated using multiple logistic regression.

Compared with participants with BMI <25 kg/m

, those with BMI ≥30 kg/m

(obesity) at ages 20 years and 30 years and approximately 10 years before diagnosis or interview had 2.56- (95% confidence interval, 1.20-5.44), 2.06- (confidence interval, 1.25-3.40), and 1.88- (95% confidence interval, 1.30-2.73) fold risk of early-onset CRC. The association of BMI with early-onset CRC risk was particularly pronounced among, and essentially restricted to, the majority of participants with no previous colonoscopy.

Obesity at early adulthood is strongly associated with increased risk of early-onset CRC. German Clinical Trials Register ID DRKS00011793.

Obesity at early adulthood is strongly associated with increased risk of early-onset CRC. German Clinical Trials Register ID DRKS00011793.

The sucrase-isomaltase (SI) c.273_274delAG loss-of-function variant is common in Arctic populations and causes congenital sucrase-isomaltase deficiency, which is an inability to break down and absorb sucrose and isomaltose. Children with this condition experience gastrointestinal symptoms when dietary sucrose is introduced. We aimed to describe the health of adults with sucrase-isomaltase deficiency.

The association between c.273_274delAG and phenotypes related to metabolic health was assessed in 2 cohorts of Greenlandic adults (n= 4922 and n= 1629). A sucrase-isomaltase knockout (Sis-KO) mouse model was used to further elucidate the findings.

Homozygous carriers of the variant had a markedly healthier metabolic profile than the remaining population, including lower body mass index (β [standard error], -2.0 [0.5] kg/m

 ; P= 3.1× 10

), body weight (-4.8 [1.4] kg; P= 5.1× 10

), fat percentage (-3.3% [1.0%]; P= 3.7× 10

), fasting triglyceride (-0.27 [0.07] mmol/L; P= 2.3× 10

), and remnant cholesterol ted by reduced dietary sucrose uptake and possibly also by higher levels of circulating acetate.Systemic inflammatory response, as observed in sepsis and severe COVID-19, may lead to endothelial damage. Therefore, we aim to compare the extent of endothelial injury and its relationship to inflammation in both diseases. We included patients diagnosed with sepsis (SEPSIS group, n = 21), mild COVID-19 (MILD group, n = 31), and severe COVID-19 (SEVERE group, n = 24). Clinical and routine laboratory data were obtained, circulating cytokines (INF-γ, TNF-α, and IL-10) and endothelial injury markers (E-Selectin, Tissue Factor (TF) and von Willebrand factor (vWF)) were measured. Compared to the SEPSIS group, patients with severe COVID-19 present similar clinical and laboratory data, except for lower circulating IL-10 and E-Selectin levels. Compared to the MILD group, patients in the SEVERE group showed higher levels of TNF-α, IL-10, and TF. There was no clear relationship between cytokines and endothelial injury markers among the three studied groups; however, in SEVERE COVID-19 patients, there is a positive relationship between INF-γ with TF and a negative relationship between IL-10 and vWF.

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