Burkschambers4916

Each year, almost 35% of children are exposed to maternal depression and more grow up in persistent poverty, increasing the risk for stress-related disease and other socio-developmental deficits later in life. These impacts are likely related to chronic stress via the hypothalamic-pituitary-adrenal (HPA) axis. However, there is little evidence relating early windows of child HPA axis activity to multiple exposures.

We investigated chronic measures of hair-derived HPA axis hormones (cortisol and dehydroepiandrosterone (DHEA)) in 104 one-year old infants from rural Pakistan and longitudinal measures of maternal depression, intimate partner violence (IPV), socio-economic status (SES), and the home environment.

Estimates from adjusted linear mixed effects models did not reveal consistent significant associations between infant cortisol and maternal depression or home adversities. By contrast, infants exposed to maternal depression during pregnancy had lower DHEA levels (ß= -0.18 95% confidence interval [CI]smissions of maternal depression, IPV, and household environment on infant stress-response systems.

Ketamine is established as a rapid and effective treatment in adults with treatment-resistant depression (TRD). The availability of different formulations and routes of delivery invites the need for evaluating relative effect sizes.

Effect size with respect to depression symptom reduction for each formulation and route of delivery was compared at discrete time-points (i.e., 24h, 2-6 days, 7-20 days, 21-28 days) in adults with TRD. A random-effects meta-analysis was conducted to evaluate the effect size across intravenous, intranasal and oral routes of administration. Analysis was also conducted evaluating the effect size of racemic ketamine to esketamine.

The pooled effect size for intranasal ketamine/esketamine at 24h was g=1.247 (n=5, 95% CI 0.591-1.903, p<0.01). At 2-6 days, the pooled effect size for intravenous ketamine/esketamine was g=0.949 (n=14, 95% CI -0.308-2.206, p=0.139). At 7-20 days, intranasal ketamine had a pooled effect size of g=1.018 (n=4, 95% CI 0.499-1.538, p<0.01). At 21-28 om this analysis. Direct comparative studies are needed to further inform treatment options for TRD.

Anhedonia is a trans-diagnostic, multidimensional phenotype that mediates patient outcomes and suicidality. Convergent evidence suggests that ketamine may be effective in targeting measures of anhedonia in adults with treatment resistant depression (TRD).

This retrospective, post-hoc analysis included 203 (x̄=45±14.6 years of age) patients receiving four infusions of intravenous (IV) ketamine at a community-based clinic. The primary outcome measure was change in anhedonia severity, as measured by the Snaith-Hamilton Pleasure Scale (SHAPS). Secondary measures sought to determine if improvement on the SHAPS mediated the effect of repeated IV ketamine infusions on symptoms of depression and suicidal ideations, as measured by the Quick Inventory for Depression Symptomatology-Self Report 16-Item (QIDS-SR

) and anxiety, as measured using the Generalized Anxiety Disorder-7 (GAD-7).

After adjusting for age, sex, primary diagnosis, concomitant medication, body mass index, and baseline depression severity, thereent in depressive symptoms, suicidality, and anxiety.

There is a scarcity of studies in the international literature regarding alternative treatment to the pharmacological and psychotherapeutic intervention in the face of depression symptoms. This study aimed to test a protocol based on natural therapy, alternatives to pharmacological and psychotherapeutic, through Mindfulness Meditation, Reiki, Acupuncture and Auriculotherapy, to treat the symptoms of depression for those who were with no pharmacological or psychotherapeutic treatment for these symptoms.

this is a randomized single-blind controlled pilot study. The final sample was 21 participants divided in two groups experimental and control. Participants were evaluated by validated instruments during the screening process and after the intervention. The instruments were Depression, Anxiety and Stress Scale and Beck Depression Inventory. Intervention was performed in eight sessions, during two months. All the techniques were used in the experimental group. Analysis of variance with repeated measures was used to compare pre-intervention to post-intervention moments.

the result of analysis indicates a significant reduction in the symptoms of depression after the intervention among the experimental group.

there is no way to determine which of the techniques used produced the most significant result.

The protocol proposed in this study was effective in reducing the symptoms of depression to whom are not eligible for traditional treatment.

The protocol proposed in this study was effective in reducing the symptoms of depression to whom are not eligible for traditional treatment.

There was an outbreak of COVID-19 towards the end of 2019 in China, which spread all over the world rapidly. The Chinese healthcare system is facing a big challenge where hospital workers are experiencing enormous psychological pressure. This study aimed to (1) investigate the psychological status of hospital workers and (2) provide references for psychological crisis intervention in the future.

An online survey was conducted to collect sociodemographic features, epidemic-related factors, results of PHQ-9, GAD-7, PHQ-15, suicidal and self-harm ideation (SSI), and the score of stress and support scales. Chi-square test, t-test, non-parametric, and logistic regression analysis were used to detect the risk factors to psychological effect and SSI.

8817 hospital workers participated in this online survey. Panobinostat cost The prevalence of depression, anxiety, somatic symptoms, and SSI were 30.2%, 20.7%, 46.2%, and 6.5%, respectively. Logistic regression analysis showed that female, single, Tujia minority, educational backgrtal workers, which needed to be addressed. County hospital workers were more severe and easier to be neglected. More studies on cognitive and behavioral subsequence after a public health disaster among hospital workers are needed.