Burgessespinoza8498
In the Chinese health care industry, male
Oliv. flowers are newly approved as a raw material of functional food. DNA Damage chemical Core collections have been constructed from conserved germplasm resources based on phenotypic traits and molecular markers. However, little is known about these collections' phytochemical properties. This study explored the chemical composition of male
flowers, in order to provide guidance in the quality control, sustainable cultivation, and directional breeding of this tree species.
We assessed the male flowers from 22 core collections using ultra-performance liquid chromatography and quadrupole time-of-flight mass spectrometry (UPLC-QTOF/MS) non-targeted metabolomics, and analyzed them using multivariate statistical methods including principal component analysis (PCA), hierarchical cluster analysis (HCA), and orthogonal partial least squares discriminant analysis (OPLS-DA).
We annotated a total of 451 and 325 metabolites in ESI+ and ESI- modes, respectively, by aligning the mass fragm is a suitable approach to the chemotype classification and biomarker screening of male E. ulmoides flower core collections. We first evaluated the metabolite profiles and compositional variations of male E. ulmoides flowers in representative core collections before establishing possible chemotypes and significant biomarkers denoting the variations. We used genetic variations to infer the metabolite compositional variations of male E. ulmoides flower core collections instead of using the geographical origins of the germplasm resources. The newly proposed biomarkers sufficiently classified the chemotypes to be applied for germplasm resource evaluation.
Cold therapy has the disadvantage of inducing vasoconstriction in arterial and venous capillaries. The effects of carbon dioxide (CO
) hot water depend mainly on not only cutaneous vasodilation but also muscle vasodilation. We examined the effects of artificial CO
cold water immersion (CCWI) on skin oxygenation and muscle oxygenation and the immersed skin temperature.
Fifteen healthy young males participated. CO
-rich water containing CO
>1,150 ppm was prepared using a micro-bubble device. Each subject's single leg was immersed up to the knee in the CO
-rich water (20°C) for 15 min, followed by a 20-min recovery period. As a control study, a leg of the subject was immersed in cold tap-water at 20°C (CWI). The skin temperature at the lower leg under water immersion (T
-WI) and the subject's thermal sensation at the immersed and non-immersed lower legs were measured throughout the experiment. We simultaneously measured the relative changes of local muscle oxygenation/deoxygenation compared to theperiod. The T
-WI stayed lower with the CCWI compared to the CWI, as it is associated with vasodilation by CO
.
The combination of CO2 and cold water can induce both more increased blood inflow into muscles and volume-related (total heme concentration) changes in deoxy[Hb+Mb] during the recovery period. The Tsk-WI stayed lower with the CCWI compared to the CWI, as it is associated with vasodilation by CO2.The scientific method has provided the 21st allopathic healer with many powerful and effective tools to combat disease. However, the management of technology does not equate with being a healer. The integral healer not only utilizes the power of the scientific method but also balances its application with compassionate intention and wise perspective. This article describes the characteristics of the 4 pillars of becoming an integral healer (competency, compassion, wisdom, and self-cultivation) and describes how each one of these pillars is vital to being a healer.
To investigate the retinal nerve fiber layer profile measured by optical coherence tomography and its relation to refractive error and axial length.
The Gutenberg Health Study is a population-based study in Mainz, Germany. At the five-year follow-up examination, participants underwent optical coherence tomography, objective refraction and biometry. Peripapillary retinal nerve fiber layer (pRNFL) was segmented using proprietary software. The pRNFL profiles were compared between different refraction groups and the angle between the maxima, i.e., the peaks of pRNFL thickness in the upper and lower hemisphere (angle between the maxima of pRNFL thickness [AMR]) was computed. Multivariable linear regression analysis was carried out to determine associations of pRNFL profile (AMR) including age, sex, optic disc size, and axial length in model 1 and spherical equivalent in model 2.
A total of 5387 participants were included. AMR was 145.3° ± 23.4° in right eyes and 151.8° ± 26.7° in left eyes and the pRNFL profile was significant different in the upper hemisphere. The AMR decreased with increasing axial length by -5.86°/mm (95% confidence interval [CI] [-6.44; -5.29],
< 0.001), female sex (-7.61°; 95% CI [-8.71; -6.51],
< 0.001) and increased with higher age (0.08°/year; 95% CI [0.03; 0.14],
= 0.002) and larger optic disc size (2.29°/mm
; 95% CI [1.18; 3.41],
< 0.001). In phakic eyes, AMR increased with hyperopic refractive error by 2.60°/diopters (dpt) (95% CI [2.33; 2.88],
< 0.001).
The pRNFL profiles are related to individual ocular and systemic parameters.
Biometric parameters should be considered when pRNFL profiles are interpreted in diagnostics, i.e., in glaucoma.
Biometric parameters should be considered when pRNFL profiles are interpreted in diagnostics, i.e., in glaucoma.
To quantitatively measure meibomian gland (MG) tortuosity in meibomian gland dysfunction (MGD) patients and normal controls and to observe the efficacy of evaluating MG tortuosity for the diagnosis of MGD.
This cross-sectional study enrolled 32 obstructive MGD patients and 28 normal volunteers. Clinical assessments were performed, including symptom questionnaires, tear meniscus height, tear break-up time (TBUT), corneal fluorescein staining, lid margin abnormality, MG expressibility, and meibography. The meibomian gland tortuosity and meibomian gland density were measured by VIA software.
The mean age of the patients in the MGD group was 33.28 ± 9.28 years, and that of the normal controls was 25.25 ± 11.19 years. The average tortuosity of all MGs in the MGD patients was significantly larger than in the normal controls (
0.05). We further stratified the MGD patients into symptomatic MGD and asymptomatic groups. The average tortuosity of all MGs and of the central eight MGs was significantly higher in the symptomatic MGD patients than in the asymptomatic MGD patients (
0.
