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The mapping results were validated against manually digitized lake outlines derived from Gaofen-2 panchromatic multi-spectral (GF-2 PMS) imagery, with an overall accuracy and kappa coefficient of 96.54% and 0.95, respectively. In comparison with results from classical supervised support vector machine (SVM) and unsupervised Iterative Self-Organizing Data Analysis Technique Algorithm (ISODATA) methods, the proposed method proved to be much more robust and effective at detecting glacial lakes with irregular boundaries that have similar backscattering as the surroundings. This study also demonstrated the feasibility of time-series Sentinel-1A/1B SAR data in the continuous monitoring of glacial lake outline dynamics.The use of robots to map disaster-stricken environments can prevent rescuers from being harmed when exploring an unknown space. In addition, mapping a multi-robot environment can help these teams plan their actions with prior knowledge. The present work proposes the use of multiple unmanned aerial vehicles (UAVs) in the construction of a topological map inspired by the way that bees build their hives. A UAV can map a honeycomb only if it is adjacent to a known one. Different metrics to choose the honeycomb to be explored were applied. At the same time, as UAVs scan honeycomb adjacencies, RGB-D and thermal sensors capture other data types, and then generate a 3D view of the space and images of spaces where there may be fire spots, respectively. Simulations in different environments showed that the choice of metric and variation in the number of UAVs influence the number of performed displacements in the environment, consequently affecting exploration time and energy use.Three-dimensional calculations of the meniscus of a magnetic fluid placed around a current carrying vertical and cylindrical wire are presented. Based on the material properties of experimentally used magnetic fluids, the numerically determined menisci are compared with the experimentally measured ones reported by May. The comparison is made for a linear law of magnetisation as well as for the experimentally measured nonlinear magnetisation curve. Up to moderate strengths of the applied current ( I less then = 45 A), i.e., up to moderate strengths of the magnetic field close to the wire, the calculated profiles agree satisfyingly with the experimentally measured ones for a linear as well as for a nonlinear law of magnetisation. At a great strength of the applied current ( I = 70 A), i.e., at a large strength of the magnetic field close to the wire, the agreement is less good than in the range up to moderate strengths. Our analysis revealed that the numerically assumed isothermal conditions are not present in the experiment, particularly at the great strength of the applied current. LTGO-33 cell line A control of the temperature in the experiment and the implementation of a coupled thermal model in the numerics are considered the most relevant future steps for an improved agreement.Among environmental factors likely associated with Alzheimer's disease (AD), persistent virus infections, and age-related progressive decline of immune competence might play a pivotal role. However, AD antimicrobial brain immune responses are poorly investigated. The present study focused on genes involved in antimicrobial defenses, especially against virus infections, in the AD brain. In particular, mRNA levels of IRF7, MED23, IL28B, and IFN-α genes were analyzed in hippocampus and temporal cortex brain samples from AD and non-demented controls. All subjects were also genotyped for APOE ε, IRF7, MED23, and IL28B gene polymorphisms. Most AD patients showed decreased mRNA levels of all investigated genes in the hippocampus and temporal cortex. However, a small group of AD patients showed increased hippocampal mRNA expression of MED23, IL28B, and IFN-α. mRNA levels of MED23, IL28B, IFN-α from the hippocampus and those of MED23 from the temporal cortex were further decreased in APOE ε4 allele AD carriers. Moreover, rs6598008 polymorphism of IRF7 was significantly associated with decreased hippocampal expression of IRF7, MED23, IL28B, and IFN-α. These findings suggest that AD brains show impaired innate antimicrobial gene expression profiles, and individual genetic makeup, such as positivity for the APOE ε4 and IRF7 A alleles, might affect brain immune efficiency.T-type calcium channels (TTCCs) are overexpressed in several cancers. In this review, we summarize the recent advances and new insights into TTCC biology, tumor progression, and prognosis biomarker and therapeutic potential in the melanoma field. We describe a novel correlation between the Cav3.1 isoform and the increased basal autophagy in BRAFV600E-mutant melanomas and after acquired resistance to BRAF inhibitors. Indeed, TTCC blockers reduce melanoma cell viability and migration/invasion in vitro and tumor growth in mice xenografts in both BRAF-inhibitor-sensitive and -resistant scenarios. These studies open a new, promising therapeutic approach for disseminated melanoma and improved treatment in BRAFi relapsed melanomas, but further validation and clinical trials are needed for it to become a real therapeutic option.Detection of an environmental contaminant requires the use of expensive measurement equipment, which limits the realization of in situ tests because of their high cost, their limited portability, or the extended time duration of the tests. This paper presents in detail the development of a portable low-cost spectrophotometer which, by using a specialized chemosensor, allows detection of mercuric ions (Hg2+), providing effective and accurate results. Design specifications for all the stages assembling the spectrophotometer and the elements selected to build them are presented along with the process to synthesize the chemosensor and the tests developed to validate its performance in comparison with a high-precision commercial laboratory spectrophotometer.The purpose of this study was to clarify whether there have been any specific changes in the characteristics of the world's top-level women's singles badminton matches compared to men's singles matches after the current badminton scoring system was implemented in 2006. We compared the characteristics of the matches between the Super Series tournaments in 2007 and 2017. Match duration increased as the rally and rest times increased in both men's and women's singles matches. Specifically, in women's singles, it was suggested that a further increase in physical demands because of the increased number of shots per second may have resulted in longer rest time in proportion to rally time. Moreover, increases in match duration (final eight, 53.3 ± 6.6 min; early rounds, 42.1 ± 3.6 min; P less then 0.05) and number of shots per rally (final eight, 10.4 ± 1.2; early rounds, 8.7 ± 1.1; P less then 0.05) in women's singles were more prominent in the final eight rounds (quarterfinals, semifinals, and finals) than in the early rounds (rounds 1 and 2).