Buchananharrison7797

The proposed ensemble framework is evaluated by extensive experiments with regression and classification data sets. SNX-5422 purchase Comparisons with other state-of-the-art ensemble methods confirm that GNCL yields the best overall performance.A central capability of a long-lived reinforcement learning (RL) agent is to incrementally adapt its behavior as its environment changes and to incrementally build upon previous experiences to facilitate future learning in real-world scenarios. In this article, we propose lifelong incremental reinforcement learning (LLIRL), a new incremental algorithm for efficient lifelong adaptation to dynamic environments. We develop and maintain a library that contains an infinite mixture of parameterized environment models, which is equivalent to clustering environment parameters in a latent space. The prior distribution over the mixture is formulated as a Chinese restaurant process (CRP), which incrementally instantiates new environment models without any external information to signal environmental changes in advance. During lifelong learning, we employ the expectation-maximization (EM) algorithm with online Bayesian inference to update the mixture in a fully incremental manner. In EM, the E-step involves estimating the posterior expectation of environment-to-cluster assignments, whereas the M-step updates the environment parameters for future learning. This method allows for all environment models to be adapted as necessary, with new models instantiated for environmental changes and old models retrieved when previously seen environments are encountered again. Simulation experiments demonstrate that LLIRL outperforms relevant existing methods and enables effective incremental adaptation to various dynamic environments for lifelong learning.The performance of a biologically plausible spiking neural network (SNN) largely depends on the model parameters and neural dynamics. This article proposes a parameter optimization scheme for improving the performance of a biologically plausible SNN and a parallel on-field-programmable gate array (FPGA) online learning neuromorphic platform for the digital implementation based on two numerical methods, namely, the Euler and third-order Runge-Kutta (RK3) methods. The optimization scheme explores the impact of biological time constants on information transmission in the SNN and improves the convergence rate of the SNN on digit recognition with a suitable choice of the time constants. The parallel digital implementation leads to a significant speedup over software simulation on a general-purpose CPU. The parallel implementation with the Euler method enables around 180x (20x) training (inference) speedup over a Pytorch-based SNN simulation on CPU. Moreover, compared with previous work, our parallel implementation shows more than 300x (240x) improvement on speed and 180x (250x) reduction in energy consumption for training (inference). In addition, due to the high-order accuracy, the RK3 method is demonstrated to gain 2x training speedup over the Euler method, which makes it suitable for online training in real-time applications.Modeling the temporal behavior of data is of primordial importance in many scientific and engineering fields. Baseline methods assume that both the dynamic and observation equations follow linear-Gaussian models. However, there are many real-world processes that cannot be characterized by a single linear behavior. Alternatively, it is possible to consider a piecewise linear model which, combined with a switching mechanism, is well suited when several modes of behavior are needed. Nevertheless, switching dynamical systems are intractable because their computational complexity increases exponentially with time. In this article, we propose a variational approximation of piecewise linear dynamical systems. We provide full details of the derivation of two variational expectation-maximization algorithms a filter and a smoother. We show that the model parameters can be split into two sets static and dynamic parameters, and that the former parameters can be estimated offline together with the number of linear modes, or the number of states of the switching variable. We apply the proposed method to the head-pose tracking, and we thoroughly compare our algorithms with several state of the art trackers.The early and reliable detection of COVID-19 infected patients is essential to prevent and limit its outbreak. The PCR tests for COVID-19 detection are not available in many countries, and also, there are genuine concerns about their reliability and performance. Motivated by these shortcomings, this article proposes a deep uncertainty-aware transfer learning framework for COVID-19 detection using medical images. Four popular convolutional neural networks (CNNs), including VGG16, ResNet50, DenseNet121, and InceptionResNetV2, are first applied to extract deep features from chest X-ray and computed tomography (CT) images. Extracted features are then processed by different machine learning and statistical modeling techniques to identify COVID-19 cases. We also calculate and report the epistemic uncertainty of classification results to identify regions where the trained models are not confident about their decisions (out of distribution problem). Comprehensive simulation results for X-ray and CT image data sets indicate that linear support vector machine and neural network models achieve the best results as measured by accuracy, sensitivity, specificity, and area under the receiver operating characteristic (ROC) curve (AUC). Also, it is found that predictive uncertainty estimates are much higher for CT images compared to X-ray images.Alternative splicing produces different isoforms from the same gene locus. Although the prediction of gene(miRNA)-disease associations have been extensively studied, few (or no) computational solutions have been proposed for the prediction of isoform-disease association (IDA) at a large scale, mainly due to the lack of disease annotations of isoforms. However, increasing evidences confirm the close connections between diseases and isoforms, which can more precisely uncover the pathology of complex diseases. Therefore, it is highly desirable to predict IDAs. To bridge this gap, we propose a deep neural network based solution (DeepIDA) to fuse multi-type genomics and transcriptomics data to predict IDAs. Particularly, DeepIDA uses gene-isoform relations to dispatch gene-disease associations to isoforms. In addition, it utilizes two DNN sub-networks with different structures to capture nucleotide and expression features of isoforms, Gene Ontology data and miRNA target data, respectively. After that, these two sub-networks are merged in a dense layer to predict IDAs.