Bruussingh6949
A new assignment for photodetachment spectroscopy of AuCl2- is proposed where contribution of the 2Δg state is considered. The ground state of AgCl2 is calculated to be the 2B2 state of the C2v structure in scalar-relativistic (SR) calculations, while the SOC quenches the RTE and PJTE and the ground state becomes the 2Π3/2g state of the D∞h structure. As for the other molecules, the ground state is calculated to be the 2Πg state in SR cases, and the 2Π3/2g state with SOC. Our results indicate that a higher level electron correlation, large basis set and SOC are important to achieve reliable results for these molecules.The present work reports the fabrication of anion-induced electrical devices with Zn(ii) metal-organic frameworks. The essence of our electronic device fabrication is to utilize the anionic species entrapped inside of the three-dimensional network of the MOFs for charge transportation. The idea is to generate MOFs as a host-guest system with encapsulated anions or anion-solvent clusters as guests and a cationic yet insulating three-dimensional framework as the host. Accordingly, we have synthesized two Zn(ii) MOFs using a neutral bispyrazole-based ligand, which results in a cationic chassis with substantial void space and porous channels inside the network. For both MOFs, the porous channels are occupied by infinitely hydrogen bonded networks of anions and anion-solvent clusters. This provides an excellent platform for anionic species-induced charge transportation and improved electrical conductivity. Indeed, the impedance spectroscopy data and current density-voltage (J-V) characteristics of the fabricated electrical devices further vindicate our idea. The current-voltage measurements clearly indicate the usefulness of modified host-guest-type MOFs for electronic device fabrication with corroborating conductivity values of 8.71 × 10-5 S m-1 and 5.79 × 10-4 S m-1 for compound 1 and compound 2, respectively.Heptamethine cyanine dyes (Cy7) have attracted much attention in the field of biological application due to their unique structure and attractive near infrared (NIR) photophysical properties. In this review, the influences of different modification sites on the absorption characteristics, photostability, Stokes shift, fluorescence characteristics, water solubility, and singlet oxygen generation efficiency of this class of dyes are summarized, and the application development of the corresponding dyes in the field of biological application is introduced, which will provide a reference for the optimization and improvement of heptamethine cyanine dyes in the future.Metastasis and spread are currently the main factors leading to high mortality of cancer, so developing a synergetic antitumor strategy with high specificity and hypotoxicity is in urgent demand. Based on the design concept of "nanocatalytic medicine", multifunctional nanotherapeutic agent FePt@COP-FA nanocomposites (FPCF NCs) are developed for cancer treatment. Specifically, in the tumor microenvironment (TME), FePt could catalyze intracellular over-expressed H2O2 to generate highly active hydroxyl radicals (˙OH), which could not only induce the apoptosis of tumor cells, but also activate the "ferroptosis" pathway resulting in the lipid peroxide accumulation and ferroptotic cell death. Moreover, owing to the excellent photothermal effect, the FPCF NCs could effectively ablate primary tumors under near-infrared (NIR) laser irradiation and produce numerous tumor-associated antigens in situ. With the assistance of a checkpoint blockade inhibitor, anti-CTLA4 antibody, the body's specific immune response would be initiated to inhibit the growth of metastatic tumors. Temsirolimus ic50 In particular, such synergistic therapeutics could produce an effective immunological memory effect, which could prevent tumor metastasis and recurrence again. In summary, the FPCF NC is an effective multifunctional antitumor therapeutic agent for nanocatalytic/photothermal/checkpoint blockade combination therapy, which exhibits great potential in nanocatalytic anticancer therapeutic applications.
This study compared the efficacy/safety of the camptothecin analogues belotecan and topotecan for sensitive-relapsed small-cell lung cancer (SCLC).
One-hundred-and-sixty-four patients were randomised (11) to receive five consecutive daily intravenous infusions of topotecan (1.5 mg/m
) or belotecan (0.5 mg/m
), every 3 weeks, for six cycles. Main outcomes were objective response rate (ORR), disease control rate (DCR), progression-free survival (PFS), overall survival (OS), tolerability and toxicity. The study statistical plan was non-inferiority design with ORR as the endpoint.
In the belotecan vs. topotecan groups, ORR (primary endpoint) was 33% vs. 21% (p = 0.09) and DCR was 85% vs. 70% (p = 0.030). PFS was not different between groups. Median OS was significantly longer with belotecan than with topotecan (13.2 vs. 8.2 months, HR = 0.69, 95% CI 0.48-0.99), particularly in patients aged <65 years, with more advanced disease (i.e., extensive-stage disease, time to relapse 3-6 months), or Eastern Cooperative Oncology Group performance status 1 or 2. More belotecan recipients completed all treatment cycles (53% vs. 35%; p = 0.022).
The efficacy/safety of belotecan warrants further evaluation in Phase 3 trials. Belotecan potentially offers an alternative to topotecan for sensitive-relapsed SCLC, particularly in patients aged <65 years, with more advanced disease, or poor performance.
The efficacy/safety of belotecan warrants further evaluation in Phase 3 trials. Belotecan potentially offers an alternative to topotecan for sensitive-relapsed SCLC, particularly in patients aged less then 65 years, with more advanced disease, or poor performance.
Cervical cancer (CC) remains a leading cause of gynaecological cancer-related mortality with infection by human papilloma virus (HPV) being the most important risk factor. We analysed the association between different viral integration signatures, clinical parameters and outcome in pre-treated CCs.
Different integration signatures were identified using HPV double capture followed by next-generation sequencing (NGS) in 272 CC patients from the BioRAIDs study [NCT02428842]. Correlations between HPV integration signatures and clinical, biological and molecular features were assessed.
Episomal HPV was much less frequent in CC as compared to anal carcinoma (p < 0.0001). We identified >300 different HPV-chromosomal junctions (inter- or intra-genic). The most frequent integration site in CC was in MACROD2 gene followed by MIPOL1/TTC6 and TP63. HPV integration signatures were not associated with histological subtype, FIGO staging, treatment or PFS. HPVs were more frequently episomal in PIK3CA mutated tumours (p = 0.
