Browninghopkins3918

6; 95% confidence interval [CI] 1.2 - 19.5, p=0.03) and implementation of IBMA was an independent preventive factor for MRSA colonization (HR 0.4; 95% CI 0.1 - 0.9, p=0.04). MRSA positive patients admitted significantly earlier and stayed longer preoperatively than MRSA negative patients. CONCLUSIONS In neonates undergoing surgery, patients with Down syndrome, early diagnosis after birth and a long waiting period before operation may be associated with MRSA colonization. IBMA may be beneficial for preventing MRSA colonization. This article is protected by copyright. All rights reserved.Lysine acetyltransferases (KATs) are a highly diverse group of epigenetic enzymes that play important roles in various cellular processes including transcription, signal transduction, and cellular metabolism. However, our knowledge of the genomic and transcriptomic alterations of KAT genes and their clinical significance in human cancer remains incomplete. We performed a metagenomic analysis of 37 KATs in more than 10,000 cancer samples across 33 tumor types, focusing on breast cancer. We identified associations among recurrent genetic alteration, gene expression, clinicopathological features, and patient survival. Loss-of-function analysis was performed to examine which KAT has important roles in growth and viability of breast cancer cells. We identified that a subset of KAT genes, including NAA10, KAT6A, and CREBBP, have high frequencies of genomic amplification or mutation in a spectrum of human cancers. Importantly, we found that three KATs, NAA10, ACAT2, and BRD4, were highly expressed in the aggressive basal-like subtype, and their expression was significantly associated with disease-free survival. GSK2256098 in vivo Furthermore, we demonstrated that depletion of NAA10 inhibits basal-like breast cancer growth in vitro. Our findings provide a strong foundation for further mechanistic research and for developing therapies that target NAA10 or other KATs in human cancer. This article is protected by copyright. All rights reserved.BACKGROUND To examine the effects of Keratin 6A (KRT6A) protein on the proliferation, migration and invasion abilities of lung adenocarcinoma cells, and to analyse the relationship between the expression level of KRT6A protein and the survival prognosis of lung adenocarcinoma patients. METHODS Western Blot was used to detect the expression of KRT6A protein in lung adenocarcinoma cell lines. CCK-8 experiment and colony formation assays were performed to detect the proliferation ability. Wound healing assay and transwell migration assay were conducted to detect the migration ability. Transwell invasion assay was conducted to detect the invasion ability. Immunohistochemistry was used to detect the expression of KRT6A protein in lung adenocarcinoma tissues. RESULTS We first found that the expression of KRT6A protein in lung adenocarcinoma cell lines was low. After overexpressed KRT6A protein in lung adenocarcinoma cells, we then found that KRT6A protein could not only inhibit the proliferation ability of lung adenocarcinoma cells but also inhibit them migration and invasion abilities. In addition, we also found that there had obvious difference in the expression of KRT6A protein in between patients. And through further analysis, we finally discovered that high expression of KRT6A protein was related to favourable prognosis in lung adenocarcinoma patients. CONCLUSIONS KRT6A protein inhibits the proliferation, migration and invasion abilities of lung adenocarcinoma cells, and high expression of KRT6A protein is a predictor of good prognosis in patients with lung adenocarcinoma. © 2020 John Wiley & Sons Ltd.PURPOSE To report the prevalence of pseudoexfoliation (PEX) syndrome and glaucoma associated with PEX (PEX-G) and their relating factors of them in a south-western island of Japan. METHODS A population-based survey of all residents aged ≥ 40 years was conducted in Kumejima, Okinawa, Japan, and 3762 subjects (participation rate, 81.2%) underwent detailed ophthalmic examinations. Presence of PEX material on the lens capsule, iris surface and/or pupillary margin was determined by slit-lamp biomicroscopy. Glaucoma was diagnosed according to the criteria of the International Society of Geographical and Epidemiological Ophthalmology. RESULTS In subjects aged ≥ 40 years, prevalence rates of PEX syndrome, PEX without glaucoma and PEX-G in at least one eye were 1.5% (95% confidence interval [CI] 1.0-1.9%), 1.3% (95% CI 0.9-1.7%) and 0.1% (95% CI 0.0-0.2%), respectively, excluding eyes after cataract surgery; and 2.8% (95% CI 2.3-3.3%), 2.2% (95% CI 1.8-2.6 %) and 0.4% (95% CI 0.2-0.6%), respectively, including eyes after cataract surgery. Cataract surgery had been performed in 61% of subjects with PEX in at least one eye; presence of PEX showed no significant effects on the intraocular pressure (IOP). A multivariate analysis showed that PEX was associated with older age (p  less then  0.0001, odds ratio 1.10 [95% CI 1.07-1.13]) and working outdoors (p = 0.0395, odds ratio 2.18 [95% CI 0.99-4.82]). CONCLUSIONS The prevalence rates of PEX syndrome and PEX-G in a south-western island of Japan were reported. PEX showed no significant effect on IOP, and age and working outdoors were significantly related with PEX. © 2020 Acta Ophthalmologica Scandinavica Foundation. Published by John Wiley & Sons Ltd.Large-scale terrestrial carbon estimating studies using methods such as atmospheric inversion, biogeochemical modeling, and field inventories have produced different results. The goal of this study was to integrate fine-scale processes including land use and land cover change into a large-scale ecosystem framework. We analyzed the terrestrial carbon budget of the conterminous U.S. from 1971 to 2015 at 1-km resolution using an enhanced dynamic global vegetation model (DGVM) and comprehensive land cover change data. Effects of atmospheric CO2 fertilization, nitrogen deposition, climate, wildland fire, harvest, and land use/land cover change (LUCC) were considered. We estimate annual carbon losses from cropland harvest, forest clearcut and thinning, fire, and LUCC were 436.8, 117.9, 10.5, and 10.4 TgC yr-1 , respectively. Carbon stored in ecosystems increased from 119,494 to 127,157 TgC between 1971 and 2015, indicating a mean annual net carbon sink of 170.3 TgC yr-1 . Although ecosystem net primary production increased by approximately 12.3 TgC yr-1 , most of it was offset by increased carbon loss from harvest and natural disturbance and increased ecosystem respiration related to forest aging. As a result, the strength of the overall ecosystem carbon sink didn't increase over time. Our modeled results indicate the conterminous U.S. carbon sink was about 30% smaller than previous modeling studies, but converged more closely with inventory data. This article is protected by copyright. All rights reserved.Verrucae are benign proliferations seen in skin due to infection with papillomaviruses. There are different treatment strategies for warts but all of these treatments are painful, time consuming, expensive, and recurrence is common. To evaluate and compare the efficacy of intralesional 2% zinc sulfate solution vs vitamin D3 in the treatment of plantar warts, as well as reporting the side effects. This three-armed randomized clinical trial included 105 patients presented with plantar warts divided into three groups, 35 patients per group. The first group received intralesional 2% zinc sulfate, the second group received intralesional 2% vitamin D3, and the third group received normal saline. Four sessions were done, one every 2 weeks. At the end of the study, patients showing complete response were more in zinc group (71.4%), vitamin D3 group (62.9%) compared to saline group (40%). Most of the patients in zinc group showed severe pain during injection (48.6%), most of the patients in vitamin D3 group showed mild pain (80%), while most of the patients in saline group showed no pain (57.1%). Both intralesional 2% zinc sulfate and vitamin D3 are effective in treatment of plantar warts, with zinc sulfate being more effective. © 2020 Wiley Periodicals, Inc.Bariatric surgery is an effective treatment option for patients with type 2 diabetes mellitus (T2DM) and obesity. This study aims to compare the effects of Roux-en-Y gastric bypass (RYGB) and sleeve gastrectomy (SG) on remission of T2DM. MEDLINE, EMBASE, and the Cochrane Central Register of Controlled Trials were searched for studies published between database inception and 21 November 2019. A meta-analysis, using a random effects model, was performed to calculate relative risk (RR) of T2DM remission between the groups in randomized controlled trials (RCTs). Of 2650 records identified, 12 records from 10 different RCTs were finally included. The studies comprised 705 patients with follow-up from 1 to 5 years. The remission rate of T2DM at 1 year was higher among those undergoing RYGB (156/276, 57%) compared with those undergoing SG (128/275, 47%), RR (95% CI) 1.20 (1.00-1.45), P = .047, I2 = 24.9%, moderate-quality evidence. Among studies with 2- to 5-year follow-up, there was no difference in remission rates between the RYGB (132/263, 50%) and SG (121/266, 46%) groups, RR 1.06 (0.94-1.20), P = .34, I2 = 0.0%, low-quality evidence. RYGB resulted in a higher rate of T2DM remission compared with SG after 1 year. The T2DM remission rates did not differ in studies with 2- to 5-year follow-up. © 2020 The Authors. Obesity Reviews published by John Wiley & Sons Ltd on behalf of World Obesity Federation.Transition metal oxides vastly limit practical applications due to their rapid capacity decay as an electrode material for lithium-ion batteries (LIBs). Here, we have successfully employed a versatile strategy to mitigate the volume expansion and low conductivity of Fe 3 O 4 via coating a thin carbon layer on the surface of Fe 3 O 4 nanosheets (NSs). Benefiting from the 2D core-shell structures, the Fe 3 O 4 @C NSs exhibit significantly improved rate performance and cycle capability compared to bare Fe 3 O 4 NSs. Along with 200 cycles, the discharge capacity at 0.5 A g -1 is shown to be 963 mAh g -1 (93% retained). Moreover, the lithium storage reaction mechanism is detailed studied by ex situ XRD and HRTEM techniques. When coupled with the commercial LiFePO 4 cathode, the full-cell retains a capacity of 133 mAh g -1 after 100 cycles at 0.1 A g -1 , demonstrating its superior energy storage performance. This work provides a guidance to construct novel 2D metal oxide-carbon composites with high performance and low cost for the field of energy storage. © 2020 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.BACKGROUND Successful facilitation of patient-centred interventions for self-management support has traditionally focussed on individual behaviour change. A social network approach to self-management support implicates the need for facilitation that includes an orientation to connecting to and mobilizing support and resources from other people and the local environment. OBJECTIVE To identify the facilitation processes through which engagement with a social network approach to self-management is achieved. METHOD Thematic analysis was used to analyse data from a longitudinal study design using quasi-ethnographic methods comprising non-participant observation, video and qualitative interviews involving 30 participants living with a long-term condition recruited from a marginalized community. RESULTS Findings centred on three themes about the social network approach facilitation processes reversing the focus on the self by bringing others into view; visualization and reflection as a mediator of positive disruption and linking to new connections; personalized matching of valued activities as a means of realizing preference elicitation.