Brogaardkirkeby9258

The non-homogenized liposomes were more effective than their homogenized version. These findings were also confirmed by FTIR measurements. This suggests that our approach to liposomal development has considerable potential for the repair of a disrupted skin barrier.The mechanical properties of powders determine the ease of manufacture and ultimately the quality of the oral solid dosage forms. Although poor mechanical properties of an active pharmaceutical ingredient (API) can be mitigated by using suitable excipients in a formulation, the effectiveness of that approach is limited for high dose drugs or multidrug tablets. In this context, improving the mechanical properties of the APIs through solid form optimisation is a good strategy to address such a challenge. This work explores the powder and tableting properties of various lamotrigine (LAM) solid forms with the aim to facilitate direct compression by overcoming the poor tabletability of LAM. The two drug-drug crystals of LAM with nicotinamide and valproic acid demonstrate superior flowability and tabletability over LAM. The improved powder properties are rationalised by structure analysis using energy framework, scanning electron microscopy, and Heckel analysis.Chemical incompatibility of the formulation with glass container can adversely impact the quality of parenteral products. The objective of this study is to investigate formulation-glass interactions at the inner surface of the glass containers that lead to the generation of particulates under stressed conditions (i.e., combinations of high pHs, temperatures and prolonged exposure selected to purposely cause failure of glass containers) using advanced microscopic techniques. The optical, electron microscopy and X-ray spectroscopy were used in tandem to investigate the nature of these interactions at the vial inner surface. These interactions were characterized by surface roughness and reaction zones on the inner surface of the vials and particulates in the formulation using two commercially available pharmaceutical glass containers (Vials 1 and 2). A nanoscale level examination of the inner surface of Vial 1 revealed layers flaking off from the inner surface of the vial resulting in typical particulate generation, while the reaction zone on the inner surface of Vial 2 exhibited a different layered structure. The results suggest that particulates observed in Vials 1 and 2 were generated through different failure modes.Lyophilized powders containing myoglobin and various excipients were subjected to ssHDX-MS at different temperatures and D2O vapor activity (RH). Deuterium incorporation was fitted to a bi-exponential association model for each formulation and the dependence of regression parameters on temperature and RH was evaluated. Data fitted best to a simplified model in which the slow exponential term was considered invariant with temperature and RH while the fast exponential term retained its temperature and RH dependence. This suggests that rapid rate processes such as water vapor sorption and initial deuterium labeling may be more dependent on temperature and RH than slower processes such as sequential exchange and transport in the solid matrix.The identification of bacterial infections as a significant human-life threatening challenge is driving several research efforts toward generating new strategies to treat bacterial infections and associated resistance issues. Biomimicry is an emerging field demonstrating great potential for application in the war against bacterial infection and their associated diseases. Recently, nanotechnology combined with biomimetic concepts has been identified as an innovative strategy to combat bacterial infections. Herein, we present an up-to-date review of biomimetic antibacterial nanosystems, with a focus on the different biomimetic approaches involved in the synthesis and delivery of antibacterial nanosystems. Biomimetic synthesis and nanosystems involved in mimicking cellular structures, extracellular matrix structures and biological surfaces are critically reviewed. Their advantages achieved in biocompatibility, biodegradability, improvement of pharmacokinetics parameters and antibacterial efficiency are highlighted. Current challenges and recommendations for amplifying the potential of these systems are also identified. This review illustrates the significant impact and potential of biomimetic antibacterial nanosystems in the field of bacterial infection treatment.Milling is commonly used for controlling the size distribution of granules in the pharmaceutical dry granulation process. A thorough understanding of the breakage of single compacts is crucial in unravelling the complex interactions that exist between different pharmaceutical feed materials and the mill process conditions. However, limited studies in the literature have examined the impact breakage of single pharmaceutical compacts. In this study, pharmaceutical powders including the microcrystalline MCC 101, MCC 102 and MCC DG were compressed at different pressures and tablets with different porosities and thicknesses were produced. Impact breakage tests were conducted in an air gun and the tablet impact velocities and breakage patterns were analysed using a Phantom ultrahigh-speed camera. It was observed that the tablet breakage rate and the amount of fines reduced as the tablet porosity decreased. In addition, thin tablets with low porosity exhibited semi-brittle fracture and less intense crack propagation while thick tablets with high porosity primarily disintegrated into fine fragments. Thus, this study provides a better understanding of the breakage behaviour of different pharmaceutical materials and can potentially be used to describe the breakage modes of compacts in the ribbon milling processes.Lipid nanoparticles are increasingly used for drug and gene delivery, including the delivery of small interfering RNA (siRNA). Pulmonary delivery of drug molecules carried by lipid nanoparticles directly into the lung may improve the treatment of certain lung diseases. The present study was designed to test the feasibility of engineering aerosolizable dry powder of lipid nanoparticles by thin-film freeze-drying (TFFD). Solid lipid nanoparticles (SLNs) comprised of lecithin, cholesterol, and a lipid-polyethylene glycol conjugate were prepared by solvent evaporation. Dry powders of the SLNs were prepared by TFFD, spray drying, or conventional shelf freeze-drying. find more The physical and aerosol properties of the dry powders as well as the physical properties of the SLNs reconstituted from the dry powders were evaluated. The particle size, polydispersity index, and the zeta potential of the SLNs were preserved after they were subjected to TFFD and reconstitution, but not after they were subjected to conventional shelf freeze-drying and reconstitution, and the dry powder prepared by TFFD showed better aerosol performance properties than that prepared by spray drying.