Brockhenningsen1143

at identifying a genetic diagnosis for a child's DEE can be a psychological turning point for families. A genetic result has the potential to set these families on an adaptive path toward better quality of life through increased understanding, social connection, and support. Early access to genetic testing is important as it not only increases clinical utility, but also increases personal utility with early mitigation of family stress, trauma, and negative experiences.

A major source of disability for people with epilepsy involves uncertainty surrounding seizure timing and severity. Although patients often report that long seizure-free intervals are followed by more severe seizures, there is little experimental evidence supporting this observation. Optimal characterization of seizure severity is debated; however, seizure duration is associated with seizure type and can be quantified in electrographic recordings as a limited proxy of clinical seizure severity. Here, using chronic intracranial electroencephalography (cEEG), we investigate the relationship between interseizure interval (ISI) and duration of the subsequent seizure.

We performed a retrospective analysis of 14 subjects implanted with a responsive neurostimulation device (RNS System) that provides cEEG, including timestamps of electrographic seizures. We determined seizure durations for isolated seizures and for representative seizures from clusters determined through unsupervised methods. For each subject, thgoverning the dynamics of focal seizures.

By leveraging cEEG and accounting for seizure clusters, we found that the likelihood of long-duration seizures positively correlates with ISI length, in a subset of individuals. These findings corroborate anecdotal clinical observations and support the existence of capacitor-like long memory processes governing the dynamics of focal seizures.

The Psychology Task Force of the Medical Therapies Commission of the International League Against Epilepsy (ILAE) has been charged with taking steps to improve global mental health care for people with epilepsy. This study aimed to inform the direction and priorities of the Task Force by examining epilepsy healthcare providers' current practical experiences, barriers, and unmet needs around addressing depression and anxiety in their patients.

A voluntary 27-item online survey was distributed via ILAE chapters and networks. It assessed practices in the areas of screening, referral, management, and psychological care for depression and anxiety. A total of 445 participants, from 67 countries (68% high income), commenced the survey, with 87% completing all components. Most respondents (80%) were either neurologists or epileptologists.

Less than half of respondents felt adequately resourced to manage depression and anxiety. There was a lack of consensus about which health professionals were responsible for sn of mental health professionals within epilepsy settings.

The findings suggest that while the importance of managing depression and anxiety in patients with epilepsy is being recognized, there are ongoing barriers to effective mental health care. Key future directions include the need for updated protocols in this area and the integration of mental health professionals within epilepsy settings.

To assess the quality of life among caregivers of children with epilepsy in a tertiary care center of eastern Nepal.

A cross-sectional study was conducted among primary caregivers of children with epilepsy, who accompanied their child in child neurology clinic. Consecutive sampling was done, and 106 respondents were interviewed. Data were collected using World Health Organization Quality of Life-BREF (WHOQOL-BREF) scale and analyzed using Statistical Package for the Social Sciences. Descriptive and Inferential statistics were applied.

Mean WHOQOL-BREF score was 82.25 standarddeviation (SD) ±12.11. Transformed scores (0-100) for each domain were 57.98±14.55 in physical, 55.87±13.16 in psychological, 53.12±13.42 in social, and 52.52±13.04 in environmental domain. Mean score for overall perceptionof quality of life (QOL) was 2.71±0.79 and was 3.12±0.75 for overall perceptionof health. Living below poverty line (

=.03) and poor seizure control status of children (

=.46) were significantly associated with lower total QOL score. Living below poverty line was significantly associated with low social relationship (

=.003) and environment domain (<0.001) scores.

Epilepsy has a multifaceted impactonthe livesof affected people. Caring children with epilepsy is associated with enormous psychosocial effects on parents and family members. Caregivers' QOL may affect the treatment and outcome of epilepsy in children. Given the consideration to scarcity of this kind of literature in Nepalese context, this study was conducted.

Epilepsy has a multifaceted impact on the lives of affected people. Caring children with epilepsy is associated with enormous psychosocial effects on parents and family members. Caregivers' QOL may affect the treatment and outcome of epilepsy in children. Given the consideration to scarcity of this kind of literature in Nepalese context, this study was conducted.

Patients with drug-resistant epilepsy (DRE) pose considerable management challenges for patients, their families, and providers. check details Both the vagus nerve stimulator (VNS) and the ketogenic diet (KD) have been shown to be safe and effective in treating DRE. Nevertheless, information is lacking regarding treatment with combination of both modalities. This study reports the efficacy and tolerability of combining VNS and KD in a pediatric cohort with intractable epilepsy.

This is a retrospective review of 33 patients (0-17years) with DRE treated with VNS and KD at a single pediatric level IV epilepsy center. We compared seizure reduction rates for each patient at baseline and at every clinic visit for 24months after adding the second nonpharmacological therapy. The frequency of adverse events on the combined therapy was collected to assess safety and tolerability.

There were a total of 170 visits for all patients while on the combined therapy. At 88% (95% CI 83%-93%) of the visits, patients reported some reduction in seizure frequency.