Brinkbritt8773

Concentration evolutions of the various radionuclides obtained with the simulations were analyzed for five different cases to explore variations in the infiltration and recharge rates, the effect of assuming physical equilibrium or non-equilibrium transport conditions, and of different initial concentrations of some of the radionuclides.The aim of our study was to isolate populations of keratinocyte stem cells based on the expression of cell surface markers and to investigate whether the culture could affect their phenotype. keratinocytes from human oral mucosa were sorted based on the expression of the epithelial stem cell markers p75NTR and CD71. We also examined the co-expression of other epithelial stem markers such as integrins β1 and α6 and their stem cell-like proprieties in in vitro assays. Three passages after being sorted by MACS, more than 93% of the p75NTR+ve cells lost the expression of p75NTR, while 5.46% of the p75NTR-ve gained it. Within the small population of the p75NTR+ve cells, 88% co-expressed other epithelial stem cell markers such as integrins β1 and α6, while only 28% of p75NTR-ve cells co-expressed these markers. These results were confirmed by sorting cells by FACS. Additionally, when double staining was used for sorting cells, 99% of the p75NTR+veCD71-ve and 33% of the p75NTR-veCD71+ve cells expressed both integrins, but just one week after culture, only 1.74% of the p75NTR+veCD71-ve cells still expressed p75NTR and only 0.32% still expressed CD71. Similar results were obtained when co-culturing p75NTR+ve and p75NTR-ve populations before analysis. Our results suggest that phenotype changes may be part of an intrinsic cellular mechanism to conserve levels of protein expression as they may found in the human body. In addition, in vitro culture may not offer ideal conditions for epithelial stem cell maintenance due to phenotype changes under standard culture conditions.About 92,000 new cases of oropharynx carcinoma are expected to occur annually worldwide. There is no consensus about the best therapy for these advanced tumors. The objective of the present study was to evaluate overall and disease-free survival rates of patients with advanced oropharynx squamous cell carcinoma, comparing surgery + radiotherapy with chemotherapy + radiotherapy. Medical records of patients were reviewed. Previously treated tumors were excluded. Clinical, demographic and microscopic information was collected, and p16 staining was performed. Kaplan-Meier survival curves were plotted. Forty-seven cases were included, 41 men and 6 women, having a mean age of 56.3 years. Most patients were smokers (85.1%) and consumed alcohol (74.5%). Patients were stage III (21.3%) or IV (78.7%). Most lesions affected the base of the tongue (36.2%). Of the 23 cases available for p16 testing, 3 were positive (13.0%). There was no difference between the overall and the disease-free survival rates for the two treatment modalities (p>0.05), even when only resectable tumors were compared. Seventeen cases experienced recurrence (36.2%); 16 (34.0%) patients remained alive without disease; 15 (31.9%) died due to disease; 9 (19.2%) were recurrent at the last follow-up. The two treatment protocols were equally efficient in treating advanced oropharynx squamous cell carcinoma, since both promoted similar overall and disease-free survival rates. The results and interpretations related herein mostly regard "conventional" oropharyngeal squamous cell carcinomas, as opposed to HPV-associated tumors.PURPOSE To investigate the effects of adalimumab pretreatment on the lipopolysaccharide-mediated myocardial injury. METHODS Twenty-eight Wistar rats were randomized into four groups (n=7). Control (C) group animals were injected once a day with intraperitoneal (i.p) 0.9 % saline for two days. In the Adalimumab (Ada) group, adalimumab was injected at a dose of 10 mg/kg/ day (i.p) for two days. Lipopolysaccharide (Lps) group rats were injected with a dose of 5 mg/kg (i.p) lipopolysaccharide. Lipopolysaccharide + Adalimumab (Lps+Ada) group rats received adalimumab before the administration of lipopolysaccharide. The animals were sacrificed 24 h after the last injection and blood samples were obtained for determination of biochemical cardiac injury markers and circulating levels of TNF-α and interleukin-6 (IL-6). Hearts were harvested for histological examination. RESULTS Endotoxin exposure resulted in significant increases in serum cardiac injury markers, serum cytokines and histological myocardial injury scores in the Lps group. The levels of circulating cytokines, cardiac injury markers and histological injury scores for myocardial necrosis, perivascular cell infiltration, and inflammation were significantly reduced in Lps+Ada as compared to Lps group (p less then 0.05). CONCLUSIONS Adalimumab pretreatment reduces endotoxin-induced myocardial damage in rats. This beneficial effect is thought to be related to the reduction of cytokine release.The detailed structure of active polymer gels built by integrating light-driven rotary molecular motors as reticulation units in polymer networks is discussed as a function of gel composition. Upon light-irradiation, the collective rotation of molecular motors is translated into the macroscopic contraction of the gels through polymer chains twisting. The major role of the characteristic ratio c/c* (c* being the overlap concentration of the polymer-motor conjugates before crosslinking) on the contraction efficiency is exploited. Combined small-angle neutron and X-ray scattering experiments reveal the importance of heterogeneities in the macroscopic contraction process the mesh size of the network increases under irradiation in the whole range of c/c*, an increase that is maximal for c/c* = 1; i.e. at higher contraction efficiency. Furthermore, the mesh size of the network reaches equilibrium within a short period of time, while the heterogeneities increase in size untill the end of the contraction process. Finally, the significant motorized twisting of polymer chains within the network allows to foresee the design of new storage energy systems.An environmentally-friendly and facile protocol for the construction of tetrasubstituted alkenes has been established with Ru(ii)-catalyzed C-H bond functionalizations under mild conditions. The method features the usage of readily available substrates, without external oxidants and additives, 100% atom economy, and excellent regioselectivity, thus enhancing the practicability of this protocol. Moreover, this transformation proceeded smoothly under aqueous conditions and could be extended to the gram scale. N-Methoxyamide, as a directing group (DG), played a vital role in the transformation.CuGaS2 is one of the most excellent visible-light-active photocatalysts for CO2 reduction and water splitting. However, CuGaS2 suffers from serious deactivation in photocatalytic reactions, which is mainly due to the photo-oxidation induced self-corrosion (Cu+ to Cu2+). Here, we constructed a CuGaS2/CdS hybrid photocatalyst dominated by a Z-scheme charge transfer mechanism. The transfer of photo-generated electrons from excited nanocrystalline CdS to CuGaS2 across the coherent interface reduces Cu2+ formation and favors Cu+ regeneration. This process suppresses the deactivation of CuGaS2 and maintains high performance. Both the activity and stability of photocatalytic CO2 reduction to produce CO over the CuGaS2/CdS hybrid were remarkably improved, which was approximately 4-fold higher than CuGaS2 and 3-fold higher than CdS in converting CO2 into CO. Our study demonstrates that even using the semiconductors prone to photo-corrosion, it is possible to obtain satisfactory catalytic activity and stability by designing efficient Z-scheme-charge-transfer-type photocatalysts.Ultralow temperature growth of silicon nanowires (SiNWs) directly upon cheap plastics is highly desirable for building high performance soft logics and sensors based on mature Si technology. In this work, a low temperature growth of SiNWs at only 70 °C has been demonstrated for the first time, upon polyethylene terephthalate plastics, by using gallium-indium (GaIn) alloy droplets that consume an amorphous Si (a-Si) layer as the precursor. The GaIn alloy droplets enable a beneficial synergetic effect that helps not only to reduce the melting temperature, but also to install a protective Gibbs adsorption layer of In atoms, which are critical to stabilize the rolling catalyst droplet, against otherwise rapid diffusion loss of Ga into the a-Si matrix. Ultra-long SiNWs can be batch-produced with a precise location and preferred elastic geometry, which paves the way for large scale integration. At less then 70 °C, a transition from rolling to sprawling dynamics is observed by in situ scanning electron microscopy, caused by reduced diffusion transport and rapid formation of discrete nuclei in the alloy droplet, which provides the basis for continuous growth of SiNWs. This unique capability and critical new understanding open the way for integrating high quality c-Si electronics directly over flexible, lightweight and extremely low cost plastics.Layered transition metal dichalcogenide (LTMD)/carbon nanocomposites obtained by incorporating conductive carbons such as graphene, carbon nanotubes (CNT), carbon nanofibers (CF), hybrid carbons, hollow carbons, and porous carbons exhibit superior electrochemical properties for energy storage and conversion. Due to the incorporation of carbon into composites, the LTMD/carbon nanocomposites have the following advantages (1) highly efficient ion/electron transport properties that promote electrochemical performance; (2) suppressed agglomeration and restacking of active materials that improve the cycling performance and electrocatalytic stability; and (3) unique structures such as network, hollow, porous, and vertically aligned nanocomposites that facilitate the shortening of the ion and electrolyte diffusion pathway. In this context, this review introduces and summarizes the recent advances in LTMD/carbon nanocomposites for electrochemical energy-related applications. First, we briefly summarize the reported synthesis strategies for the preparation of LTMD/carbon nanocomposites with various carbon materials. Following this, previous studies using rationally synthesized nanocomposites are discussed based on a variety of applications related to electrochemical energy storage and conversion including Li/Na-ion batteries (LIBs/SIBs), Li-S batteries, supercapacitors, and the hydrogen evolution reaction (HER). In particular, the sections on LIBs and the HER as representative applications of LTMD/carbon nanocomposites are described in detail by classifying them with different carbon materials containing graphene, carbon nanotubes, carbon nanofibers, hybrid carbons, hollow carbons, and porous carbons. In addition, we suggest a new material design of LTMD/carbon nanocomposites based on theoretical calculations. At the end of this review, we provide an outlook on the challenges and future developments in LTMD/carbon nanocomposite research.We investigated lattice strain on alloyed surfaces using ∼10 nm core-shell nanoparticles with controlled size, shape, and composition. We developed a wet-chemistry method for synthesizing small octahedral PdPt alloy nanoparticles and Au@PdPt core-shell nanoparticles with Pd-Pt alloy shells and Au cores. Upon introduction of the Au core, the size and shape of the overall nanostructure and the composition of the alloyed PdPt were maintained, enabling the use of the electrooxidation of formic acid as a probe to compare the surface structures with different lattice strain. We have found that the structure of the alloyed surface is indeed impacted by the lattice strain generated by the Au core. To further reveal the impact of lattice strain, we fine-tuned the shell thickness. Then, we used synchrotron-based X-ray diffraction to investigate the degree of lattice strain and compared the observations with the results of the formic acid electrooxidation, suggesting that there is an optimal intermediate shell thickness for high catalytic activity.