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ts, highlights the need for treatment-naive patients to undergo genomic profiling. IJCEP Copyright © 2020.Pretreatment inflammatory indexes including neutrophil-lymphocyte ratio (NLR), lymphocyte-monocyte ratio (LMR), platelet-lymphocyte ratio (PLR), and systemic immune-inflammation index (SII) are associated with poor outcomes in various malignant tumors, but their prognostic value in patients with osteosarcoma is poorly known. This was a retrospective study of patients with osteosarcoma treated between 01/2010 and 12/2013 at Chongqing University Cancer Hospital. Follow-up was calculated from the date of initial histological diagnosis to December 2018 or death or loss of follow-up. Receiver operating characteristic (ROC) analysis was used to determine the NLR, LMR, PLR, and SII cut-off values (low (L) vs. high (H)). The Kaplan-Meier method was used for survival analysis. Univariable and multivariable Cox analyses were performed to determine the independent prognostic factors. Patients with LNLR had better survival than those with HNLR (median, 38.0 vs. 13.0, P less then 0.001). Patients with LSII had better survival (26.0 vs. 10.0 months, P=0.001) than those with HSII. The areas under the curves for NLR, LMR, PLR, SII, and ALP were 0.761 (P less then 0.001), 0.683 (P=0.012), 0.697 (P=0.002), 0.653 (P=0.031), and 0.515 (P=0.837), respectively. In the univariable analyses, Enneking's stage, systemic chemotherapy, surgery, NLR, PLR, LMR, and SII were associated with overall survival (OS). The multivariable analysis showed that HNLR (HR=2.507; 95% CI=1.364-4.606; P=0.003) was independent unfavorable prognostic factors. This preliminary study suggests that NLR is associated with poor prognosis in osteosarcoma. NLR could be a potential prognostic marker of osteosarcoma. IJCEP Copyright © 2020.Most of the studies on hippocampal sulcal cavities (HSCs) have been focused on the hippocampal lesions, lacking of systemic investigations on the normal individuals. In this study, we aimed to investigate the detection rate and number of HSCs together with the correlation between HSCs and the gender, sides, hippocampal volume, and age. In total, 187 healthy subjects underwent 3.0 Tesla magnetic resonance scan. Chi square test was utilized for the comparison of HSCs detection rate among the male and female individuals. Student's t-test was used to compare the HSCs number between the subjects with different ages as well as different body sides. Analysis of variance was performed for the comparison of primary hippocampal volume, corrected hippocampal volume, and age. Person regression analysis was utilized to analyze the correlation between HSCs number and the primary hippocampal volume, corrected hippocampal volume, and age. The incidence of HSCs was 95% among the 187 subjects. There was no significant gender difference in the incidence of HSCs (P=0.448). There was no statistically significant difference in the number of HSCs on the left and right sides (P=0.093). There were statistically significant differences in mean age between groups (P less then 0.01). Pearson correlation analysis was performed on HSCs with age, hippocampal original volume and corrected volume, and the correlation coefficients were 0.316, -0.005 and 0.055. Healthy population has a high HSCs incidence, which had no significant gender-related difference. There is no significant difference of HSCs number between the left and right sides. Envonalkib HSCs showed a low correlation with age and no correlation with hippocampal volume. IJCEP Copyright © 2020.BACKGROUND RECK, as a negative MMP regulator, is extensively expressed in normal cells but decreased in tumors. In OSCC, the relationship between RECK and MMPs and the potential prognostic impact remains unclear. In this research, for the first time, we investigated the expression of RECK associated with MMPs during OSCC carcinogenesis in a large sample and its association with 5-year survival rate. MATERIAL AND METHODS Immunohistochemical SP technique was applied to study the expression of RECK and MMP-2 and MMP-9 in 108 cases of OSCC and 30 normal oral mucosae. Univariate and multivariate Cox regression analysis was utilized for disease-free survival and overall survival, and analyzed by Kaplan-Meier method regarding RECK expression in patients of OSCC. RESULTS We found lower expression of RECK in OSCC was 51.85% (56/108) compared with 93.33% (28/30) in the control group. However, the higher expression of MMP-2 and MMP-9 was 74.07% (80/108) and 70.37% (76/108) in OSCC, respectively, compared with 20% (6/30) and 13.3% (4/30) in the control group. Furthermore, the decrease of RECK expression and the increase of MMP-2, and -9 expression were significantly correlated with the loss of histologic differentiation, the occurrence of lymphatic metastasis, and the increase of OSCC clinical stage (P less then 0.05). OSCC patients with a low level of RECK expression had a lower rate of 5-year survival. CONCLUSION RECK may prevent metastasis and improve OSCC patients' prognosis through a RECK/MMP-2, and -9 imbalance. Furthermore, RECK is a prospective prognostic indicator and therapeutic target for cancer molecular targeting therapy. Low expression of RECK may be a significant negative prognostic predictor. IJCEP Copyright © 2020.BACKGROUND/AIM The association between vimentin immunoexpression and poor prognosis has been described in many human cancers. The objective of this study was to evaluate the relationship between vimentin immunostaining and colorectal carcinoma (CRC) clinicopathologic parameters. MATERIALS AND METHODS Samples included 202 primary CRC tissues, 41 adenomas and 37 normal colonic mucosae. Anti-Vimentin (V9) monoclonal antibody was used for immunohistochemical staining. Vimentin expression was evaluated based on the percentage of cytoplasmic expression in epithelial cells. RESULTS Vimentin expression was identified in 35 (17.3%) of CRC samples. All normal mucosa and adenoma samples were vimentin negative. There was an association between positive vimentin immunostaining and high tumor grade, distant metastasis, and short overall (Log rank 5.112, P=0.024), as well as disease-free survival probabilities (Log rank 6.173, P=0.013). There was no association between vimentin expression and age, gender, tumor location, tumor size, tumor stage, nodal involvement, lymphovascular invasion, margin status, or tumor recurrence.