Braysosa7215
To evaluate the effect of dexamethasone/netilmicin (dexa/net) fixed combination in the treatment of ocular inflammation after sutureless micro-incisional vitreoretinal surgery (MIVS).
This multicenter, open, randomized, active-controlled, parallel-group, clinical trial was run in 6 sites in Italy. Treatment started the day of surgery and continued 4 times daily for 14 days. Patients were 11 randomized to dexa/net (eyedrops solution and eye gel) or dexamethasone/tobramycin (dexa/tobra) eyedrops suspension and ointment. Viscous formulations (gel or ointment) were used alone during the early post-operative phase; afterwards, a combination of eye drops during daytime and viscous formulations at bedtime was adopted. The primary efficacy parameter evaluated was bulbar conjunctival hyperemia. Additional efficacy and safety parameters (palpebral conjunctival hyperemia, anterior chamber flare and cells, symptoms of ocular discomfort and ocular tolerance, adverse events and intraocular pressure) were also evaluatedxa/net is safe and effective in the treatment of post-operative inflammation following sutureless MIVS. In particular, the use of eye gel formulation is characterized by a great tolerability.Diabetic retinopathy (DR) is a microvascular complication of diabetes with a prevalence of ~35%, and is one of the leading causes of visual impairment in people of working age in most developed countries. The earliest stage of DR, non-proliferative DR (NPDR), may progress to sight-threatening DR (STDR). Thus, early detection of DR and active regular screening of patients with diabetes are necessary for earlier intervention to prevent sight loss. While some countries offer systematic DR screening, most nations are reliant on opportunistic screening or do not offer any screening owing to limited healthcare resources and infrastructure. Currently, retinal imaging approaches for DR screening include those with and without mydriasis, imaging in single or multiple fields, and the use of conventional or ultra-wide-field imaging. Advances in telescreening and automated detection facilitate screening in previously hard-to-reach communities. Despite the heterogeneity in approaches to fit local needs, an evidence base must be created for each model to inform practice. In this review, we appraise different aspects of DR screening, including technological advances, identify evidence gaps, and propose several studies to improve DR screening globally, with a view to identifying patients with moderate-to-severe NPDR who would benefit if a convenient treatment option to delay progression to STDR became available.
Multifocal intraocular lenses (IOLs) can potentially affect the intraoperative view of the retina. We investigated the suitability of different lenses for viewing the macular area through two multifocal intraocular lenses in a human eye model.
This study compared the image quality of graduated index (0.1 mm) in a model eye when viewed through refractive or diffractive multifocal IOLs with a meniscus or flat contact lens, and a wide field 60 diopter non-contact lens or wide field contact lens (Super Macula
).
Images acquired through the meniscus contact lens or flat contact lens via the central optical zone of the refractive multifocal IOL or the diffractive multifocal IOL were well focused. However, images viewed through these lenses near the center were warped and out of focus. All images viewed through a wide-field 60 diopter non-contact lens at the central optical zone and near the center were slightly out of focus. All images viewed through the Super Macula at the central optical zone and near the center were well focused.
A wide field contact lens (Super Macula
) made it possible to obtain clear images of the macular area at multiple focal points through refractive or diffractive multifocal IOLs.
A wide field contact lens (Super Macula®) made it possible to obtain clear images of the macular area at multiple focal points through refractive or diffractive multifocal IOLs.
To compare anatomical and visual results of pars plana vitrectomy (PPV) with or without additional encircling band in the management of pediatric traumatic rhegmatogenous retinal detachment (RD) in a tertiary referral center.
A retrospective review of children diagnosed with traumatic rhegmatogenous retinal detachment treated by pars plana vitrectomy with or without encircling band.
One hundred thirty-nine eyes of 139 children diagnosed with traumatic rhegmatogenous retinal detachment. Surgeries were performed between May 2011 and November 2016. Patients were followed up for at least 18 months after last intervention. The included eyes were categorized into two groups. Group A (vitrectomy with additional encircling band) included 72 eyes of 72 children; 58 boys and 14 girls. Group B (vitrectomy without encircling band) included 67 eyes of 67 children; 58 boys and 9 girls. In group A, the mean age was 9.21±3.24. Attached retina was achieved in 61% (44 out of 72 eyes), of which 34 eyes remained attached astically significant difference between the two groups (combined vitrectomy and encircling band versus vitrectomy alone in pediatric traumatic retinal detachment), it is wise to consider adding encircling band in severe trauma cases.
Visual recovery following macula involving rhegmatogenous retinal detachment remains poorly understood. The aim of this work is to correlate the functional and the anatomical changes in retinal vasculature in the foveal avascular zone using optical coherence tomography angiography (OCTA) after successful retinal reattachment repair and correlate this data with retinal thickness and post-operative visual recovery.
A prospective, comparative observational study of 28 eyes of 14 patients with 14 eyes undergoing macula off retinal detachment repair with pars plana vitrectomy, endo-laser and silicone oil-based tamponade compared with 14 fellow healthy eyes at 1, 6 and 12 weeks post-operative period. The study was conducted at the Research Institute of Ophthalmology, Giza, Egypt between February 2018 and August 2018.
The foveal avascular zone (FAZ) area in the patients group was not significantly different compared to the control group and was found to be negatively correlated with the central retinal thicknel avascular zone during the recovery phase after successful retinal reattachment involving macula.[This corrects the article DOI 10.2147/OPTH.S267993.].
The objective of this study was to assess the rate of posterior capsule opacification (PCO), under "real-life" conditions, as measured by rates of NdYAG laser intervention, rather than from a controlled study from which patients with conditions predisposing to PCO have been excluded.
This was a retrospective, multicenter study in an unselected consecutive cohort of patients undergoing surgery for senile cataract. Patients aged 18 years and older, previously implanted with the CT LUCIA 611P IOL, were contacted at 12, 18 and 24 months to ascertain if they had received NdYAG laser treatment. There was an additional assessment at 36 months at the Austrian centre.
A total of 200 patients were recruited at two centers. Laser capsulotomy rates were 4.5% at 1 year and 10% by year 2 and 12% by year 3. C381 Three NdYAG capsulotomies, carried out at other external centers, were performed for reasons other than PCO, including astigmatism, epiretinal membrane and ARMD. If these patients are excluded, the true rate of NdYAG carried out for PCO at 1 year was 3.5% and at 2 years was 8.5%.
It is critical to ensure that NdYAG capsulotomies are being performed only for the correct clinical reason. Carrying out unnecessary procedures places the patient at risk of adverse events, is a cost to the healthcare system, and is likely to have no direct visual benefit for the patient. In PCO studies, it should be a requirement to document the fibrosis grade to confirm that NdYAG capsulotomy was correctly indicated.
It is critical to ensure that NdYAG capsulotomies are being performed only for the correct clinical reason. Carrying out unnecessary procedures places the patient at risk of adverse events, is a cost to the healthcare system, and is likely to have no direct visual benefit for the patient. In PCO studies, it should be a requirement to document the fibrosis grade to confirm that NdYAG capsulotomy was correctly indicated.
To compare clinical outcomes in a prospective trial of cataract surgery patients bilaterally implanted with two different trifocal intraocular lenses (IOLs) with very similar optical designs but consisting of different IOL materials (hydrophobic and hydrophilic).
Fifty-one patients (102 eyes) were randomized to receive trifocal IOLs bilaterally - FineVision POD F (hydrophilic) or FineVision POD F GF (hydrophobic) (both PhysIOL, Liége, Belgium). The follow-up period was 3 months. Outcome measurements included uncorrected distance (UDVA), corrected distance (CDVA), distance-corrected intermediate (DCIVA), and distance-corrected near visual acuity (DCNVA), refraction, negative dysphotopsia, optical quality of vision, contrast sensitivity under photopic and mesopic conditions, halometry (discrimination index), and patient-reported outcomes.
At the final study visit, mean (SD) values for binocular UDVA, CDVA, DCIVA (80 cm), and DCNVA (40 cm) were -0.01 (0.06), -0.04 (0.04), 0.09 (0.10), and 0.10 (0.09) logMAes allows the surgeon to choose the IOL material based on personal preferences or patients' needs.
To identify the laser programming strategy that achieves the highest refractive astigmatism outcomes accuracy between LYRA surgical planning and Phorcides surgical planning.
One hundred one eyes successfully treated with Contoura with LYRA Protocol were retrospectively surgically planned with Phorcides to determine its accuracy. Eighteen eyes that had inaccurate 3 month outcomes with LYRA were also retrospectively planned with Phorcides. Two patients with one eye treated with LYRA and one with Phorcides surgical planning were analyzed for outcomes.
Retrospective Phorcides surgical planning deviated from already successful treatments with LYRA Protocol 51% of the time, with an average astigmatic deviation of 0.69 diopters (D) and an average deviation of 7.1 degrees. The percentage of eyes of the 101 successfully treated with LYRA Protocol then planned with Phorcides differed by 0.5D in 19.8%, by 0.75D in 23.8%, and by 1D in 7.9%. A retrospective analysis with Phorcides of patients treated with LYRA Protocol with residual post-operative astigmatism demonstrated that Phorcides would have increased accuracy in only 33% of patients, and not helped or decreased accuracy in the rest.
Phorcides was significantly less accurate in surgical planning than the LYRA Protocol overall and a 51% of primary patients could have a likelihood of significant residual astigmatism. Phorcides would also have provided a less accurate outcome in the majority of patients that needed secondary enhancement.
Phorcides was significantly less accurate in surgical planning than the LYRA Protocol overall and a 51% of primary patients could have a likelihood of significant residual astigmatism. Phorcides would also have provided a less accurate outcome in the majority of patients that needed secondary enhancement.
