Bradleyknox3834
Granularity was also positively associated with RSA during seated rest periods, although this relationship did not reach significance in this sample. These findings are consistent with constructionist accounts of emotion that propose concepts as a key mechanism underlying individual differences in emotional experience, physiological regulation, and physical health.
To investigate the effect of a new powered toothbrush with tapered bristles on the brush head for the reduction of dental plaque and gingivitis.
This was a single-centre, single-group, longitudinal clinical trial. Thirty-two participants who were typical manual toothbrush users were recruited and assigned the sonic-poweredbrush. Interviews were arranged on the 1
, 4
, and 15
days which represented the baseline (T
), middle (T
) and final (T
) time points, respectively. At each visit, the plaque index (PlI), gingival index (GI), bleeding on probing (BOP) and probing depth (PD) were recorded for the Ramfjord index teeth, gingivalcrevicularfluid(GCF) samples were collected and the proportions of eight periodontal pathogenic bacteria were analysed. Repeated-measures analysis of variance (ANOVA) was used for comparisons at different time points.
PlI was significantly reduced by 41.67% from T
to T
(p<0.001) and decreased by 18.57% from T
to T
(p=0.003). GI also varied significantly from T
to T
(p=0.018) and T
to T
(p=0.037). A 35.86% reduction in the BOP percentage occurred after using the sonic-powered toothbrush for 3days (p=0.001). However, no significant difference was observed in the mean values of PD at different examination intervals (p=0.529). There was no significant difference in the proportions of bacteria between T
and T
(p>0.05).
This research demonstrated the efficacy of the sonic-powered brush handle together with tapered bristles on the brush in reducing plaque and gingivitis within a short time period.
This research demonstrated the efficacy of the sonic-powered brush handle together with tapered bristles on the brush in reducing plaque and gingivitis within a short time period.The dysregulation of immune system plays a crucial function in periodontitis development. Pro-inflammatory cytokines are thought to be critical for the generation and development of periodontitis. The enhanced activity of osteoclasts contributes to periodontitis pathogenesis. Nuclear factor-κB (NF-κB) signaling pathway directly enhances osteoclast differentiation and maturation. 2-[(aminocarbonyl)amino]-5-(4-fluorophenyl)-3-thiophenecarboxamide (TPCA-1) is a IκB kinases (IKK) inhibitor. This research aimed to investigate whether TPCA-1 had influence on the pathogenesis of chronic periodontitis. Mouse chronic periodontitis was induced by an in vivo ligature-induced periodontitis model. TPCA-1 was intravenously injected into mice after chronic periodontitis induction. Bone marrow-derived macrophages were cultured in macrophage colony-stimulating factor (M-CSF)-conditioned media with receptor activator of nuclear factor-kappa B ligand (RANKL) induce in vitro osteoclast differentiation. Western blot was used to analyze protein levels and mRNA levels were analyzed through qRT-PCR. TPCA-1 promoted osteoclastogenesis and osteoclast-related gene expression in vitro. The production of pro-inflammatory cytokines in osteoclasts induced by lipopolysaccharides was inhibited by TPCA-1 in vitro. In vitro TPCA-1 treatment inhibited Aggregatibacter actinomycetemcomitans (A.a)-induced expression of pro-inflammatory cytokines and NF-κB signal activation in osteoclasts. The induction of chronic periodontitis was inhibited by the absence of IKKb in mice. This research demonstrates that the treatment of TPCA-1 negatively regulates inflammation response and inhibits the osteoclastogenesis through the inactivation of NF-κB pathway in mouse chronic periodontitis model.The presence of bacteria in the tumor can cause cancer resistance to chemotherapeutics. To fight against bacterium-induced drug resistance, herein we design self-traceable nanoreservoirs that are simultaneously loaded with gemcitabine (an anticancer drug) and ciprofloxacin (an antibiotic) and are decorated with hyaluronic acid for active tumor targeting. The nanoreservoirs have a pH-sensitive gate and an enzyme-responsive gate that can be opened in the acidic and hyaluronidase-abundant tumor microenvironment to control drug release rates. Moreover, the nanoreservoirs can specifically target the tumor regions without eliciting evident toxicity to normal tissues, kill the intratumoral bacteria, and inhibit the tumor growth even in the presence of the bacteria. Unexpectedly, the nanoreservoirs can activate T cell-mediated immune responses through promoting antigen-presenting dendritic cell maturation and depleting immunosuppressive myeloid-derived suppressor cells in bacterium-infected tumors.The possibility of engineering well-defined pores into liquid materials is fascinating from both a conceptual and an applications point of view. Although the concept of porous liquids was proposed in 2007, these materials had remained hypothetical due to the technical challenges associated with their synthesis. Over the past five years, however, reports of the successful construction of porous liquids based on existing porous scaffolds, such as coordination cages, organic cages, metal-organic frameworks, porous carbons, zeolites, and porous polymers, have started to emerge. Here, the focus is on these early reports of porous liquids as prototypes in the field, classified according to the previously defined types of porous liquids. Particular attention will be paid to design strategies and structure-property relationships. Porous liquids have already exhibited promising applications in gas storage, transportation, and chemical separations. Thus, they show great potential for use in the chemical industry. The challenges of preparation, scale-up, volatility, thermal and chemical stability, and competition with porous solids will also be discussed.The low thermodynamic potential (-0.33 V) and safe by-product of N2 /H2 O, make utilizing hydrazine oxidation reaction (HzOR) to replace thermodynamically-unfavorable and kinetically-sluggish oxygen evolution reaction a promising tactic for energy-efficient hydrogen production. However, the complexity of bifunctionality increases difficulties for effective material design, thus hindering the large-scale hydrogen generation. Herein, we present the rationally designed synthesis of superhydrophilic Ni-based multicomponent arrays (Ni NCNAs) composed of 1D nanorod-confined-nanoflakes (2D), which only needs -26 mV of working potential and 47 mV of overpotential to reach 10 mA cm-2 for HzOR and HER, respectively. Impressively, this Ni NCNA electrode exhibits the top-level bifunctional activity for overall hydrazine splitting (OHzS) with an ultralow voltage of 23 mV at 10 mA cm-2 and a record-high current density of 892 mA cm-2 at just 0.485 V, also achieves the high-speed hydrogen yield driven by a waste AAA battery for OHzS.Paired electrochemical reactions allow the optimization of both atom and energy economy of oxidation and reduction reactions. read more While many paired electrochemical reactions take advantage of perfectly matched reactions at the anode and cathode, this matching of substrates is not necessary. In constant current electrolysis, the potential at both electrodes adjusts to the substrates in solution. In principle, any oxidation reaction can be paired with any reduction reaction. Various oxidation reactions conducted on the anodic side of the electrolysis were paired with the generation and use of hydrogen gas at the cathode, showing the generality of the anodic process in a paired electrolysis and how the auxiliary reaction required for the oxidation could be used to generate a substrate for a non-electrolysis reaction. This is combined with variations on the cathodic side of the electrolysis to complete the picture and illustrate how oxidation and reduction reactions can be combined.In this retrospective single-center study, we evaluated whether/how pathogenic/likely pathogenic variants of three hereditary hemorrhagic telangiectasia (HHT)-associated genes (ENG, ACVRL1, and SMAD4) are associated with specific clinical presentations of HHT. We also characterized the morphological features of pulmonary arteriovenous malformations (AVMs) in patients with these variants. Pathogenic or likely pathogenic variants were detected in 64 patients. Using nonparametric statistical tests, we compared the type and prevalence of specific HHT diagnostic features associated with these three variants. Pathogenic variants in these genes resulted in gene-specific HHT clinical presentations. Epistaxis was present in 93%, 94%, and 100% of patients with ENG, ACVRL1, and SMAD4 variants, respectively (p = 0.79). Pulmonary AVMs were more common in patients with the ENG variant (p = 0.034) compared with other subgroups. ACVRL1 variant was associated with the lowest frequency of pulmonary AVMs (p = 0.034) but the highest frequency of hepatic AVMs (p = 0.015). Patients with the ACVRL1 variant did not have significantly more pancreatic AVMs compared with the other groups (p = 0.72). ENG, ACVRL1, and SMAD4 pathogenic or likely pathogenic variants are associated with gene-specific HHT presentations, which is consistent with results from other HHT centers.
The aim of the present study was to summarize the clinical efficacy of three-dimensional (3D) printing technology combined with the Masquelet technique in the treatment of calcaneal defects.
From January 2018 to April 2019, 3D printing combined with induced masquelet technology was used to treat four patients with calcaneal defects, including two men and two women. The patients were aged 22-52 years old, with an average age of 36 years. There were two cases of traffic accident injuries, there was one case of a fall from height, and there was one case of crush injury. CT scans were used to reconstruct the bilateral calcaneus, mirror technology was used to construct the bone defect area, and Materialise 3-matic software was used to design the calcaneus shaper mold and 3D print the mold. During the operation, the mold was used to shape the bone cement and fill the bone defect. In the second stage, the bone cement was removed and autologous bone was implanted to repair the bone defect. All patients were follogood.
Three-dimensional printing technology combined with induced membrane technology is an effective approach for treating calcaneal bone defects.
Three-dimensional printing technology combined with induced membrane technology is an effective approach for treating calcaneal bone defects.
To evaluate the cost-utility and cost-effectiveness of the dr. Bart app compared to usual care in people with knee/hip OA, applying a health care payer perspective.
This economic evaluation was conducted alongside a 6-month randomized controlled trial, involving 427 participants. The dr. Bart app is a stand-alone eHealth application which invites users to select pre-formulated goals (i.e. "tiny habits") and triggers to a healthier lifestyle. Self-reported outcome measures were health care costs, quality-adjusted life years (QALYs) according to the EuroQol (EQ-5D-3L), and the EuroQol Visual Analogue Scale (QALY-VAS), patient activation measure (PAM-13) and five subscales of KOOS/HOOS. Missing data were multiply imputed and bootstrapping was used to estimate statistical uncertainty.
Mean age of participants was 62.1(SD 7.3) years, with the majority being female(72%). Health care costs were lower for the intervention group(€-22 (95% CI -36; -3)). For QALY and QALY-VAS, the probability of the dr. Bart app being cost-effective compared to usual care was 0.
