Bowersliu4895

The incorporation of digital pathology into routine pathology practice is becoming more widespread. Definite advantages exist with respect to the implementation of artificial intelligence (AI) and deep learning in pathology, including cytopathology. However, there are also unique challenges in this regard.

This review discusses cytology-specific challenges, including the need to implement digital cytology prior to AI; the large file sizes and increased acquisition times for whole slide images in cytology; the routine use of multiple stains, such as Papanicolaou and Romanowsky stains; the lack of high-quality annotated datasets on which to train algorithms; and the considerable computer resources required, in terms of both computer infrastructure and skilled personnel, for computing and storage of data. Global concerns regarding AI that are certainly applicable to cytology include the need for model validation and continued quality assurance, ethical issues such as the use of patient data in developing algd skilled personnel, for computing and storage of data. Global concerns regarding AI that are certainly applicable to cytology include the need for model validation and continued quality assurance, ethical issues such as the use of patient data in developing algorithms, the need to develop regulatory frameworks regarding what type of data can be utilized and ensuring cybersecurity during data collection and storage, and algorithm development. Key Messages While AI will likely play a role in cytology practice in the future, applying this technology to cytology poses a unique set of challenges. A broad understanding of digital pathology and algorithm development is desirable to guide the development of algorithms, as well as the need to be cognizant of potential pitfalls to avoid when incorporating the technology in practice.We report a patient with severe Covid-19-associated coagulopathy and type 2 diabetes mellitus who tested positive for antiphospholipid antibodies (aPL). Analysis of skin specimens suggested direct SARS-CoV-2 viral-induced and complement-mediated vascular injury and thrombosis, consistent with prior reports. Serial aPL testing demonstrated high levels of anticardiolipin antibodies (aCL) that declined to insignificant levels over a period of 5 weeks. SARS-CoV-2 RNA was detected in nasopharyngeal swab specimens on serial assays performed over the same 5-week period, though it was not detected thereafter. We hypothesize that SARS-CoV-2 viral-induced aPL contributed to severe Covid-19-associated coagulopathy in this patient.Immobilization of PEG-covered silicon dots, PEGSiDs, on glass substrates was performed following a simple strategy involving particle embedding by a sol-gel process forming a silica film on glass slides. The obtained films, denoted as fSiO x -PEGSiD, constitute a water-wettable, strongly supported, photoluminescent glass coating. The films showed high capacity for photosensitizing singlet oxygen (1O2) in the UVA when immersed in water. Staphylococcus aureus colonies formed on fSiO x -PEGSiDs modified glasses revealed the inhibition of bacterial adhesion and bacterial growth leading to the formation of loosely-packed and smaller S. aureus colonies. Upon 350 nm light irradiation of the biofilmed fSiO x -PEGSiDs -modified glasses, S. selleck kinase inhibitor aureus growth was inhibited and bacteria killed reducing the number of living bacteria by three orders of magnitude. Eradication of attached bacteria was achieved by the synergistic effect exerted by a less adherent fSiO x -PEGSiDs surface that inhibits biofilm formation and the ability of the surface to photosensitize 1O2 to kill bacteria.The electronic-photonic convergent systems can overcome the data transmission bottleneck for microchips by enabling processor and memory chips with high-bandwidth optical input/output. However, current silicon-based electronic-photonic systems require various functional devices/components to convert high-bandwidth optical signals into electrical ones, thus making further integrations of sophisticated systems rather difficult. Here, we demonstrate thin-film transistor-based photoelectric memories employing CsPbBr3/CsPbI3 blend perovskite quantum dots (PQDs) as a floating gate, and multilevel memory cells are achieved under programming and erasing modes, respectively, by imputing high-bandwidth optical signals. For different bandwidth light input (i.e. 500-550, 575-650 and 675-750 nm) with the same intensity, three levels of programming window (i.e. 3.7, 1.9 and 0.8 V) and erasing window (i.e. -1.9, -0.6 and -0.1 V) are obtained under electrical pulses, respectively. This is because the blend PQDs have two different bandgaps, and different amounts of photo-generated carriers can be produced for different wavelength optical inputs. It is noticed that the 675-750 nm light inputs have no effects on both programming and erasing windows because of no photo-carriers generation. Four memory states are demonstrated, showing enough large gaps (1.12-5.61 V) between each other, good data retention and programming/erasing endurance. By inputting different optical signals, different memory states can be switched easily. Therefore, this work directly demonstrates high-bandwidth light inputting multilevel memory cells for novel electronic-photonic systems.This work describes a novel mechanism of laminar flow control of straight and backward swept wings with a comb-like leading edge device. It is inspired by the leading-edge comb on owl feathers and the special design of its barbs, resembling a cascade of complex 3D-curved thin finlets. The details of the geometry of the barbs from an owl feather were used to design a generic model of the comb for experimental and numerical flow studies with the comb attached to the leading edge of a flat plate. Due to the owls demonstrating a backward sweep of the wing during gliding and flapping from live recordings, our examinations have also been carried out at differing sweep angles. The results demonstrate a flow turning effect in the boundary layer inboards, which extends downstream in the chordwise direction over distances of multiples of the barb lengths. The inboard flow-turning effect described here, counter-acts the outboard directed cross-span flow typically appearing for backward swept wings. This flow turning behavior is also shown on SD7003 airfoil using precursory LES investigations. From recent theoretical studies on a swept wing, such a way of turning the flow in the boundary layer is known to attenuate crossflow instabilities and delay transition. A comparison of the comb-induced cross-span velocity profiles with those proven to delay laminar to turbulent transition in theory shows excellent agreement, which supports the laminar flow control hypothesis. Thus, the observed effect is expected to delay transition in owl flight, contributing to a more silent flight.In this paper, we present a segmentation and classification method for thyroid follicular neoplasms based on a combination of the prior-based level set method and deep convolutional neural network. The proposed method aims to discriminate thyroid follicular adenoma (TFA) and follicular thyroid carcinoma (FTC) in ultrasound images. In their appearance, these two kinds of tumours have similar shapes, sizes and contrasts. Therefore, it is difficult for even ultrasound specialists to distinguish them. Because of the complex background in thyroid ultrasound images, before distinguishing TFA and FTC, we need to segment the lesions from the whole image for each patient. The main challenge of segmentation is that the images often have weak edges and heterogeneous regions. The main issue of classification is that the accuracy depends on the features extracted from the segmentation results. To solve these problems, we conduct the two tasks, i.e. segmentation and classification, by a cascaded learning architecture. For segmentation, to obtain more accurate results, we exploit the Res-U-net framework and the prior-based level set method to enhance their respective abilities. Then, the classification network is trained by sharing shallow layers of the segmentation network. Testing the proposed method on real patient data shows that it is able to segment the lesion areas in thyroid ultrasound images with a Dice score of 92.65% and to distinguish TFA and FTC with a classification accuracy of 96.00%.Hollow structure and pore size are considered to be crucial to the performance of nitrogen-doped carbon materials. In this paper, a lipstick-like hollow and mesoporous nitrogen-doped carbon (HNC-1000) material is prepared using a bottom-up template participation strategy. The images by scanning electron microscopy and transmission electron microscopy show that the precursor ZnO particles, the intermediate ZnO@ZIF-8 core-shell particles, and the target HNC-1000 particles all maintain a lipstick-like morphology, and HNC-1000 is a hollow nitrogen-doped carbon material. The specific surface area and pore size analyses show that the synthesized HNC-1000 has a very rich mesoporous structure with Vmeso+macro/Vtotal of 94.8% and mean mesopore size at 13.67 nm. X-ray photoelectron spectroscopy results show that the nitrogen in the catalyst HNC-1000 is mainly pyridine nitrogen and graphite nitrogen. The prepared HNC-1000 has excellent ORR catalytic activity with onset potential (0.98 V versus RHE), half-wave potential (0.85 V versus RHE), and limiting current density (5.51 mA cm-2), which is comparable to that of commercial Pt/C (20 wt%) and superior to NC-1000 derived from pristine ZIF-8. HNC-1000 also has good stability and strong methanol tolerance, which is superior to commercial Pt/C catalyst. The improved performance of HNC-1000 is attributed to its hollow and mesoporous morphology. These findings demonstrate a stratage for the rational design and synthesis of practical electrocatalysts.True one-dimensional (1D) van der Waals materials can form two-dimensional (2D) dangling-bond-free anisotropic surfaces. Dangling bonds on surfaces act as defects for transporting charge carriers. In this study, we consider true 1D materials to be V2Se9chains, and then the electronic structures of 2D sheets composed of true 1D V2Se9chains are calculated. The (010) plane has indirect bandgap with 0.757 eV (1.768 eV), while the (11-1) plane shows a nearly direct bandgap of 1.047 eV (2.118 eV) for DFT-D3 (HSE06) correction, respectively. The (11-1) plane of V2Se9is expected to be used in optoelectronic devices because it contains a nearly direct bandgap. Partial charge analysis indicates that the (010) plane exhibits interchain interaction is stronger than the (11-1) plane. To investigate the strain effect, we increased the interchain distance of planes until an indirect-to-direct bandgap transition occurred. The (010) plane then demonstrated a direct bandgap when interchain distance increased by 30%, while the (11-1) plane demonstrated a direct bandgap when the interchain distance increased by 10%. In mechanical sensors, this change in the bandgap was induced by the interchain distance.We consider itinerant spinless electrons moving as defects in a dilute two-dimensional Ising spin system, leading to an effective interaction mediated by spin fluctuations. Coupled self-consistent equations are analyzed after expressing the spin and fermion operators in terms of Grassmann variables. The effective mass, density of states, and specific heat are evaluated. We found that at low temperature and low electron density the effective mass is reduced, whereas in the critical region it sharply diverges. At higher temperature, the fermions behave like a Fermi liquid with a small enhanced mass.