Borupwaugh9063
Anemia was the most prevalent of linezolid-induced hematological side effects in MDR-TB patients. Therefore, hemoglobin monitoring might be recommended in patients weighing less than 54 kg and after receiving linezolid therapy for at least 2 weeks.
One of the treatments for rheumatoid arthritis (RA) was methotrexate which a disease modifying antirheumatic drug therapy. The use of methotrexate required the right dose and length of therapy to achieve remission. The effectivity of methotrexate could be accounted by disease activity score 28 (DAS28) as a tool has been used clinically with a combination number of tender joints, swollen joints, erythrocyte sedimentation rate, and global clinical assessment by the patient. The aim of this study was to determine the effective dose and length of therapy methotrexate was measured by DAS28 score.
This research was a cross-sectional study and data was collected from patient medical records in Saiful Anwar Hospital, Malang, from February to July 2018. CDK inhibitor drugs The research has been given ethical clearance. The inclusion criteria for the 88 subjects were men and women, over 20 years of age, usage of only methotrexate for at least three months, an erythrocyte sedimentation rate score, uncomplicated inflammatory bowel disease, cancer, and systemic lupus erythematosus. All data obtained was entered in formula DAS28. The Statistic analysis used both Pearson and Spearman's rank correlation.
Only 16 patients achieved remission. There were not significant correlation in statistical analysis between DAS score and cumulative dose (r=-0.091; p=0.400), average dose (r=0.043; p = 0.692), maximum dose (r=0.074; p=0.492), and length of therapy (r=-0.075; p = 0.489). The initial dose of therapy methotrexate was different and the length of therapy was adjusted to the patient's health condition.
The maximum dose and length of therapy methotrexate was required to achieve remission in RA.
The maximum dose and length of therapy methotrexate was required to achieve remission in RA.
Native
BK5.2, isolated from soil of Baluran National Park, East Java, Indonesia, has been shown to be toxic against
larvae. This study aims to determine the strength and the speed of the toxicity of
BK5.2 against
larvae in lethal concentration (LC) and lethal time (LT), as well as detection of toxin structure and parasporal inclusion.
LC values were determined by the mortality of
third instar larvae after 24 and 48h exposure to five various concentrations of
BK5.2, while LT values were determined based on the mortality of
third instar larvae due to exposure to LC
concentration at 0; 0.5; 1; 2; 4; 8; 10; 20; 24; and 48h. Larvicidal toxicity was determined based on value of LC
and LC
(CFU/mL), as well as LT
and LT
(hours) analysed with Probit analysis. Parasporal inclusion was detected using transmission electron microscope (TEM) and scanning electron microscope (SEM).
Based on bioassay, LC
and LC
values were 11.6×10
and 22.7×10
CFU/mL, respectively, at 24h exposure, as well as 8.3×10
and 15.4×10
CFU/mL, respectively, at 48h exposure, while the value of LT
and LT
were 19.0 and 26.6h, respectively. Morphological observation of the dead larvae showed there was damage on abdomen and thorax region. Detection by TEM and SEM showed there was cuboidal parasporal inclusion.
Native
BK5.2 has high toxicity against
larvae and detected flatcuboidal toxin in parasporal inclusion.
Native B. thuringiensis BK5.2 has high toxicity against A. aegypti larvae and detected flatcuboidal toxin in parasporal inclusion.
Antibiotic treatments can create multi-drug resistance among several pathogens. There is a need for an antibiotic alternative to overcome this problem. In Indonesia,
(Asiatic pennywort) and
(string bamboo) are two common medicinal plants used to treat tuberculosis, diarrhea, and other symptoms. This study was done to compare the antimicrobial activity of
and
against five pathogenic bacteria, i.e.,
H37Rv strain,
,
,
, and
.
The ethanol extracts of
, and
shoot were obtained by using speed extractor, pressure, and temperature extraction. The phytochemical contents of each extract were screened. The ethanol extract's antimycobacterial activity was determined using Lowenstein Jensen (LJ) medium and antibacterial activity was determined using Kirby-Bauer methods on Mueller Hinton agar (MHA).
The phytochemical analysis showed that
extract contains alkaloids and tannins, whereas
extract contains flavonoids, alkaloids, saponins, and tannins. This study showed that
inhibited the growth of
H37Rv strain and
.
showed antimicrobial activity against all pathogenic bacteria tested, except
.
Both medicinal plants extract can inhibit the growth of five pathogenic bacteria tested, thus, have the potential as an alternative treatment, or complementary, to treat the pathogenic bacterial infection.
Both medicinal plants extract can inhibit the growth of five pathogenic bacteria tested, thus, have the potential as an alternative treatment, or complementary, to treat the pathogenic bacterial infection.
Previous research suggests that there may be intergender differences in the profile of glycemic control achievable during the treatment of type 2 diabetes mellitus. This preliminary study was conducted to determine differences in glycemic outcomes in type 2 diabetes mellitus patients amongst men and women in an Indonesian hospital.
The study was conducted at the outpatient internal medicine polyclinic of Universitas Airlangga Teaching Hospital Surabaya. This observational prospective cohort study examining outcomes for 64 patients (32men and 32 women) treated with insulin therapy. The primary outcome measure was the extent to which subjects achieved concordance with the target blood glucose parameters based on the American Diabetes Association (ADA) guidance.
After 3months of combination basal-bolus insulin treatment, the proportion of subjects who had fasting blood glucose values in the target range did not increase for either gender. For women, there was a significantly higher proportion of subjects who achieved a postprandial glucose value within the target range (p=0.
