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FCP, a greater NEB resulted in greater loss of mass from SCAT (R2 = 0.18). In turn, greater mobilization of SCAT mass led to a higher calculated feed efficiency (R2 = 0.18). However, AAT showed no such correlations. On the other hand, during ELP, loss of both SCAT and AAT mass correlated positively with feed efficiency (R2 = 0.35 and 0.33, respectively). The results indicate that feed efficiency may not be an adequate criterion for performance evaluation in cows during NEB. Greater knowledge of functional disparities between AAT and SCAT depots may improve our understanding of excessive lipomobilization and its consequences for metabolic health and performance of dairy cows during the transition period.Net energy and protein systems (hereafter called feed evaluation systems) offer the possibility to formulate rations by matching feed values (e.g., net energy and metabolizable protein) with animal requirements. The accuracy and precision of this approach relies heavily on the quantification of various animal digestive and metabolic responses to dietary changes. Therefore, the aims of the current study were, first, to evaluate the predicted responses to dietary changes of total-tract digestibility (including organic matter, crude protein, and neutral detergent fiber) and nitrogen (N) flows at the duodenum (including microbial N and undigested feed N together with endogenous N) against measurements from published studies by 2 different feed evaluation systems. These feed evaluation systems were the recently updated Institut National de la Recherche Agronomique (INRA, 2018) and the older, yet widely used, National Research Council (NRC, 2001) system. The second objective was to estimate the accuracy and precisiesponse equations are calibrated with NEL and MP values either from the INRA model or from the NRC model, the accuracy and precision (slope, root mean square prediction error, and CCC) of the predicted milk component yields responses is similar between the models. The lowest accuracy and precision were observed for milk fat yield response, with CCC values in the range of 0.37 to 0.40, compared with milk lactose and protein yields responses for which CCC values were in the range of 0.75 to 0.81.Successful health behavior change relies on the autonomy of the individual who is driven toward personally meaningful, positive goals. The medical practitioner and health care team can use several techniques to facilitate such change effectively, including motivational interviewing, cognitive behavioral restructuring, appreciative inquiry, and positive psychology techniques. Older adults can be supported to make change, and may have greater capacity to maintain those changes due to increased levels of conscientiousness. Positive psychology approaches may be effective in older adults, due to evidence that, as individuals age, they tend to prioritize activities that bring them satisfaction and emotional well-being.This article outlines key well-known population health practices at the community level that benefit all members of the community, especially older adults.This article explores the role of prevention in healthy aging from the perspective of individualized prevention in the clinic and population-based prevention with system-level support. The traditional medical model has significant limitations to effectively target impactful outcomes related to geriatric syndromes that encompass debility, frequent hospitalizations, loss of independence, and disease progression. This article reviews aspects of the clinic visit and subsequent interventions, such as immunizations and screenings, that promote disease and disability prevention. Finally, we review the value of Population Health Management as a model of care for delivering population-based, system-level supported, patient-centered health care plans.Mindfulness has been applied in several adaptations, including Mindfulness-Based Stress Reduction and Mindfulness-Based Cognitive Therapy, to treat chronic conditions in older adults. Older adults may be particularly well suited for mindfulness interventions, because they bring decades of life experience to this contemplative therapy. Mindfulness is also an appealing intervention for older adults as it is inexpensive, effective over time, and easy to access. This article examines mental and physical chronic conditions proven responsive to mindfulness, including cognitive function, anxiety, depression, sleep quality, loneliness, posttraumatic stress disorder, cardiovascular conditions, diabetes, rheumatoid arthritis, Parkinson's disease, urge urinary incontinence, and chronic pain.Healthy aging is the ability to maintain independence, purpose, vitality, and quality of life into old age despite unexpected medical conditions, accidents, and unhelpful social determinants of health. Exercise, or physical activity, is an important component of healthy aging, preventing or mitigating falls, pain, sarcopenia, osteoporosis, and cognitive impairment. A well-balanced exercise program includes daily aerobic, strength, balance, and flexibility components. Most older adults do not meet the currently recommended minutes of regular physical activity weekly. Counseling by health care providers may help older adults improve exercise habits, but it is also important to take advantage of community-based exercise opportunities.Diet is a key determinant of health and is vital to the prevention and management of chronic disease. The predictors of an individual's dietary health are complex and influenced by multiple socioeconomic, environmental, and behavioral domains. Dietary behavior change in late life requires an in-depth understanding of internal and external factors influencing the individual and knowledge of community resources available. https://www.selleckchem.com/products/Tanshinone-I.html Dietary patterns-the combination of foods and beverages consumed-may be related to quality of life and health in older adults. Dietary patterns may also be easier for individuals to adopt and understand than dietary planning based on single nutrients.Healthy aging is a process that occurs over the life cycle. Health habits established early and practiced throughout life impact longevity, the ability to reach old age, and the health with which one experiences older adulthood. The new field of lifestyle medicine addresses root causes of disease by targeting nutrition, physical activity, well-being, stress management, substance use, connectedness, and sleep. As a result, lifestyle medicine can optimize the trajectory of aging, and promote targets that have been recognized in geriatric medicine as essential to well-being and quality of life, resulting in a compression of morbidity.The population worldwide is aging and prevalence of obesity in this population is increasing. The range of consequences that effect these at-risk patients include increased risk of falls, fractures, reduced quality of life, and cognitive decline. This article describes the epidemiology of obesity, risks and benefits of weight loss, and importance of treating obesity to help promote healthy aging. Health care professionals should encourage older adults with obesity to implement healthy lifestyle behaviors including exercise and diet routine. Treating obesity in older adults mitigates the significant public health crisis, and reduces health care utilization and risk of long-term adverse events.Frailty is a complex geriatric syndrome. Frail patients typically present with an array of multiple complex symptoms and significantly reduced tolerance for medical and surgical interventions. A multidomain approach is required to effectively treat/manage frailty.Engagement and resilience constitute 2 psychological aspects of healthy aging that are commonly identified by many individuals as more important than health or longevity. Both of them play a crucial role in healthy aging. Social engagement enhances psychological well-being and improves physical and cognitive health outcomes. In times of adversity, resilience buffers the negative effects of stress and promotes return to baseline health and function. Strong resilience helps individuals become more engaged and active engagement promotes resilience. We discuss the role, health outcomes, and practical implications of these 2 major domains of healthy aging.Dementia incidence continues to rise in the United States and around the world. Although age is the single biggest risk factor for the development of dementia, it is not considered normal sequelae of aging. Although there has been little to no progress made in the past couple of decades in the treatment or cure of Alzheimer disease, there has been significant progress made in prevention. Single factors, such as hearing loss or cardiovascular risk factors, may increase the risk for cognitive decline. The opportunity to mitigate these risk factors provides an exciting new healthy aging approach to dementia prevention.Multimorbidity is a global health challenge. Here, we define multimorbidity, describe ways multimorbidity is measured, discuss the prevalence of multimorbidity and how it differs across different populations, examine mechanisms of disease and disability, and discuss the effects of multimorbidity on outcomes such as survival and function.Healthy aging long has been held as a core belief and priority of geriatrics, yet clinical, scholarly, and advocacy efforts have not kept pace with attention to multimorbidity and end-of-life care. With an aging US population and trends toward higher rates of lifestyle diseases, there is imperative for geriatricians to engage in efforts to promote healthy aging. Lifestyle medicine offers an evidence-based approach to healthy aging at any point in the life span. This emerging branch of medical practice has synergistic principles and frameworks with the field of geriatrics, which should further empower geriatricians to engage in promoting healthy aging.Healthy aging is among the key frontiers for twenty-first century geriatrics and gerontology. Gerontology is positioned to address not only disease, debility, frailty, and death but also patients' hopes to remain healthy and high functioning and optimize their wellness. Definitions, models, and metrics of healthy aging are increasingly dynamic and multidimensional, drawing from biomedicine, social sciences, older adults' perspectives, and geroscience. Given current and projected demographics, focus on healthy aging at population, health system, research, clinical, and individual levels will lower costs and burdens while improving lives. Multiple models and strategies exist to guide progress in this critical emerging area.Isoparvifuran is a benzofuran compound isolated from the heartwood of Dalbergia odorifera. Related research reported that isoparvifuran has antioxidant property. However, it is unclear whether isoparvifuran has anti-aging effects. In this research, we established an aging model, hydrogen peroxide (H2O2)-induced BJ cell senescence, to explore the protective effect of isoparvifuran on cell senescence and its related mechanisms. Our results revealed that isoparvifuran obviously attenuated H2O2-induced cell senescence, increased the cell proliferation rate,and reversed senescence-associated molecular markers expression such as cyclin D1, pRb, caveolin-1, ace-p53, p21 and p16. Moreover, isoparvifuran dose and time dependently increased the expression level of Sirtuin 1 (SIRT1) in BJ cells. The inhibition of SIRT1 obviously reversed the reduction of SA-β-gal activity and the alteration of senescence-associated molecular markers induced by isoparvifuran. Additionally, isoparvifuran also inhibited H2O2-induced AKT and S6 phosphorylation and increase of SA-β-gal activity.