Bergmannborg3856

To analyse the clinical patterns of sarcoidosis triggered by immune checkpoint inhibitors (ICIs) in patients with cancer.

The ImmunoCancer International Registry is a big data-sharing multidisciplinary network from 18 countries dedicated to evaluating the clinical research of immune-related adverse events related to cancer immunotherapies.

We identified 32 patients with biopsy-proven sarcoidosis. Underlying cancer included mainly melanoma (n=24). AGI-6780 supplier Cancer immunotherapy consisted of monotherapy in 19 cases (anti-PD-1 in 18 and ipilimumab in 1) or combined ipilimumab+nivolumab in 13. The time median interval between initiation of ICI and sarcoidosis diagnosis was 3 months (range, 2-29 months). The use of combined ICI was associated with a shorter delay in developing sarcoidosis symptoms. The disease was symptomatic in 19 (59%) cases with mostly cutaneous, respiratory and general symptoms. The organs involved included mainly the mediastinal lymph nodes (n=32), the lungs (n=11), the skin (n=10)and the eyes (n=5). Pulmonary computed tomography studies showed bilateral hilar lymphadenopathy in all cases. There was no severe manifestation. Specific systemic therapy was required in only 12 patients (37%) oral glucocorticoids in 9, and hydroxychloroquine in 3. ICIs were held in 25 patients (78%) and definitively discontinued in 18 (56%) patients. Seven patients continued ICI treatment with a second flare in one case. In six additional patients, an ICI was reintroduced with no harm, and sarcoidosis relapsed in one of them.

Our study shows that ICI-related sarcoidosis seems to have a specific profile, possibly more benign than that of idiopathic sarcoidosis, and does not necessarily imply ICI discontinuation.

Our study shows that ICI-related sarcoidosis seems to have a specific profile, possibly more benign than that of idiopathic sarcoidosis, and does not necessarily imply ICI discontinuation.

We aimed to analyze surgical outcomes of reconstructive surgery for chronic Monteggia fracture, which is one of the most challenging problems for orthopaedic surgeons.

Twenty-eight patients were followed during 55.6±32.0 months after open reduction of the radial head combined with ulnar osteotomy and annular ligament reconstruction. The mean interval from trauma was 15.1±19.6 months, and the mean age at the surgery was 9.1±3.5 years. In addition to the chronological age, elbow maturity was assessed using the Sauvegrain score. Surgical outcomes were primarily evaluated using the Kim's score. In addition, we newly defined more successful criteria for the ideal surgical outcomes, equivalent to preinjury status.

There were 19 excellent, 3 good, 4 fair, and 2 poor outcomes based on the Kim's scoring system. Among the 19 patients with excellent outcomes, 14 met our criteria for the ideal outcomes. The age (p<0.001) and the Sauvegrain score (p<0.001) were lower, and the interval (p=0.004) was shorter in udy.

The space on each side of the mouth, between the commissure of the mouth and the buccal surface of the last visible tooth, is called the buccal corridor. The size of the buccal corridor can affect perceptions of facial esthetics. We analyzed the perceptions of orthodontists, laypersons, and orthodontic patients regarding the size of buccal corridors in people with brachyfacial, mesofacial, and dolichofacial types.

Photographs of 1 male and 1 female model were modified digitally into brachyfacial, mesofacial, and dolichofacial types. Each facial type was further modified to create 5 sizes of buccal corridors. Orthodontists, adult orthodontic patients, and laypersons were invited to rate the photographs.

Orthodontists rated lower than the other groups of raters when they evaluated the female model with the buccal corridors of 20% (P<0.05). Laypersons could not distinguish the changes of the buccal corridors when evaluating the male model with brachyfacial and mesofacial (P>0.05). Orthodontic patients rated significantly higher than the orthodontists and the laypersons when evaluating the dolichofacial type of both models (P<0.05).

Orthodontists are more sensitive to the buccal corridors than are orthodontic patients and laypersons. It is only necessary to consider eliminating the patient's buccal corridors when the buccal corridor area ratio is over 15%.

Orthodontists are more sensitive to the buccal corridors than are orthodontic patients and laypersons. It is only necessary to consider eliminating the patient's buccal corridors when the buccal corridor area ratio is over 15%.

Fixed orthodontic appliances create areas of stagnation for dental biofilms and make it difficult to clean the teeth; therefore, there is a risk of developing incipient caries lesions during the orthodontic treatment. The objective of this study is to determine if the combination of 2 different therapies, phototherapy by blue light (BL) and the antimicrobial 0.12% chlorhexidine (CHX) on enamel, orthodontic brackets, and elastics, would reduce or inhibit mature Streptococcus mutans biofilms and their regrowth on these substrates 24hours after the application of the treatment; and if this treatment would interfere with bracket adhesion to the enamel.

Biofilms of S. mutans UA159 were formed for 5-days over samples composed of a bovine enamel, orthodontic bracket, and orthodontic elastic. Then, the specimens were treated with 0.89% NaCl for 1minute, BL for 12minutes (72J/cm

), 0.12% CHX for 1minute, and BL for 12minutes, followed by 0.12% CHX for 1minute (BL+CHX). link2 Biofilm was evaluated by colonies forming untic, BL+CHX eliminated the biofilms from the substrate. CHX and BL+CHX significantly reduced the bacterial viability 24hours after treatment for all substrates (P≤0.05). The media pH significantly increased when samples were treated with CHX and BL+CHX (P≤0.001). Confocal laser scanning microscopy images visually showed an abundant quantity of red cells in the samples treated with BL+CHX. link3 There was no difference in the SBS between the treatments (P ≥0.932).

The association between BL and CHX reduced S. mutans biofilm and its regrowth on an invitro orthodontic model and did not influence the bonding strength between bracket and enamel.

The association between BL and CHX reduced S. mutans biofilm and its regrowth on an in vitro orthodontic model and did not influence the bonding strength between bracket and enamel.Internal root resorption (IRR) is a pathologic process that occurs because of external stimuli that affect the pulp and result in the loss of dentinal tissue. The occurrence of IRR is considered relatively rare, and the etiology is not fully understood, although trauma is believed to be the main etiologic agent. The current study presented a case report of spontaneous remission of an IRR lesion diagnosed during orthodontic treatment. The lesion was characterized by a circular and delimited radiolucent image, located in the apical third of the root canal of the maxillary right lateral incisor diagnosed during orthodontic treatment. After the diagnosis, clinical and radiographic follow-up was performed without any intervention. The follow-up radiographic images showed loss of contour definition and reduction in the size of the lesion. At the end of orthodontic treatment, 27 months after diagnosis, the space of the lesion had been filled by tissue with similar radiopacity to the adjacent dentin, and the tooth did not change its color and response to mechanical and thermal stimuli. Eight years after the end of the treatment, the maxillary right lateral incisor still presented normal responses to vitality tests and color stability; therefore, it was impossible to notice the root canal space. The reported patient presents a possible behavior of the IRR characterized by spontaneous remission of the lesion. However, nonendodontic treatment after diagnosis should not be the routine therapy adopted for IRR because of the potential risk to the tooth.

This trial aimed to investigate the effectiveness of microosteoperforations (MOPs) in overall time taken for alignment of maxillary anterior crowding and to evaluate the alignment improvement percentage within 6months between MOPs and control groups.

Thirty adult participants (25 females and 5 males; mean age, 22.66±3.27years) with moderate upper labial segment crowding were randomly assigned into intervention and control groups using block randomization. All participants had first premolar extractions, bonded conventional fixed appliances, and 0.014-in, followed by 0.018-in nickel-titanium archwire placement for initial alignment. The intervention group received a 3-mm deep MOPs procedure under local anesthesia using a Propel device (PropelOrtho Singapore, Pte, Ltd, Winstedt Rd, Singapore) on the labial attached gingivae of maxillary incisors at monthly visits until complete alignment. Little's irregularity index was used to assess the overall changes and measure the change of tooth alignment of the 6 maxillary anterior teeth. Assessor blinding was employed.

There was no statistically significant difference in the median overall alignment duration between MOPs and control groups (139days [95% confidence interval, 115.32-161.83] vs 143days [95% confidence interval, 107.12-179.74]; hazard ratio, 0.829; P=0.467). The MOPs procedure had nosignificant effect on the alignment duration (P=0.657) and no overall significant difference in alignment improvement percentage among 2 groups on the basis of time (F=2.53; P=0.124). No harm was encountered.

The application of MOPs is no more effective in accelerating initial orthodontic alignment than conventional treatment.

This trial was registered at the ISRCTN registry with the study ID ISRCTN15080404.

https//doi.org/10.1186/ISRCTN15080404.

This work was supported by the Postgraduate Trust Fund, Faculty of Dentistry, Universiti Teknologi MARA.

This work was supported by the Postgraduate Trust Fund, Faculty of Dentistry, Universiti Teknologi MARA.

The risk of hepatocellular carcinoma (HCC) is reduced but not eliminated after nucleos(t)ide analogue (NA) therapy in chronic hepatitis B (CHB). We aimed to investigate the role of serum Prothrombin Induced by Vitamin K Absence or Antagonist-II (PIVKA-II) and alpha-fetoprotein in predicting HCC and mortality in cirrhotic CHB patients at virological remission (VR) following NA therapy.

Patients with CHB-related cirrhosis undergoing NA therapy from two medical centers in Taiwan were retrospectively included. Serum PIVKA-II were quantified by an automated chemiluminescence assay. Multivariable Cox proportional hazards regression models were used to identify predictors for HCC and death. Serial on-treatment PIVKA-II levels after VR were investigated.

Overall, 293 CHB-related cirrhosis patients were included. At VR, the mean age was 55, and the mean PIVKA-II level was 35 mAU/mL. After a mean follow-up of 78 months, 76 patients developed HCC and 19 died. After adjustment for confounding factors, alpha-fetoprotein >7ng/mL (hazard ratio [HR] 2.84, 95% confidence interval [CI] 1.73-4.67) and PIVKA-II >50 mAU/mL (HR 2.46, 95%CI 1.35-4.49) at VR significantly predicted HCC development. In patients with alpha-fetoprotein ≤10ng/mL or ≤20ng/mL at VR, PIVKA-II >50 mAU/mL increased 2.45 or 3.16-fold risk of HCC, respectively. PIVKA-II levels after VR increased serially in patients who developed HCC afterwards.

In patients with CHB-related cirrhosis, serum alpha-fetoprotein >7ng/mL and PIVKA-II >50 mAU/mL at the time of antiviral therapy-induced VR is associated with a greater risk of HCC. PIVKA-II is a predictive marker for HCC in patients with low normal alpha-fetoprotein level.

50 mAU/mL at the time of antiviral therapy-induced VR is associated with a greater risk of HCC. PIVKA-II is a predictive marker for HCC in patients with low normal alpha-fetoprotein level.