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Experiment 3 manipulated the framing of the option attributes, which were confounded with the default in the original study, and found that the original framing led to below-chance performance while the alternate framing led to above-chance performance. Together, our results cast doubt on the prevalence and generalizability of default neglect, and instead suggest that people are capable of setting optimal defaults in attempts at social influence.Retrospectively obvious events are frequently missed when attention is engaged in another task-a phenomenon known as inattentional blindness. Although the task characteristics that predict inattentional blindness rates are relatively well understood, the observer characteristics that predict inattentional blindness rates are largely unknown. Previously, expert radiologists showed a surprising rate of inattentional blindness to a gorilla photoshopped into a CT scan during lung-cancer screening. read more However, inattentional blindness rates were higher for a group of naïve observers performing the same task, suggesting that perceptual expertise may provide protection against inattentional blindness. Here, we tested whether expertise in radiology predicts inattentional blindness rates for unexpected abnormalities that were clinically relevant. Fifty radiologists evaluated CT scans for lung cancer. The final case contained a large (9.1 cm) breast mass and lymphadenopathy. When their attention was focused on searching for lung nodules, 66% of radiologists did not detect breast cancer and 30% did not detect lymphadenopathy. In contrast, only 3% and 10% of radiologists (N = 30), respectively, missed these abnormalities in a follow-up study when searching for a broader range of abnormalities. Neither experience, primary task performance, nor search behavior predicted which radiologists missed the unexpected abnormalities. These findings suggest perceptual expertise does not protect against inattentional blindness, even for unexpected stimuli that are within the domain of expertise.Treatment of brain-related diseases is one of the most strenuous challenges in drug delivery research due to numerous hurdles, including poor blood-brain barrier penetration, lack of specificity, and severe systemic toxicities. Our research primarily focuses on the delivery of natural therapeutic compound, α-asarone, for the treatment of brain-related diseases. However, α-asarone has poor aqueous solubility, bioavailability, and stability, all of which are critical issues that need to be addressed. This study aims at formulating a lipid nanoparticulate system of α-asarone (A-LNPs) that could be used as a brain drug delivery system. The physicochemical, solid-state properties, stability, and in vitro and in vivo studies of the A-LNPs were characterized. The release of α-asarone from the A-LNPs was prolonged and sustained. After intravenous administration of A-LNPs or free α-asarone, significantly higher levels of α-asarone from the A-LNPs were detected in murine plasma and brain parenchyma fractions, confirming the ability of A-LNPs to not only maintain a therapeutic concentration of α-asarone in the plasma, but also transport α-asarone across the blood-brain barrier. These findings confirm that lipid nanoparticulate systems enable penetration of natural therapeutic compound α-asarone through the blood-brain barrier and may be a candidate for the treatment of brain-related diseases.The accumulation of potentially toxic elements (PTEs) in terrestrial ecosystems has become a global concern, as PTEs may exert a wide range of negative impacts on forest's ecological state due to local or transboundary pollution. Forest vegetation and soil display great potential as means of coping with the accumulation mechanisms, absorption and dissolving the pollutants. Therefore, it is crucial to study the transfer of PTEs across these basic components of the forest ecosystem. Investigation on the PTEs concentrations in the soil-plant system in relatively non-polluted environment of Central Balkan National Park (Sredna Stara Planina Mountain) provides more information about the role of the forest patterns and soil properties for the bioaccumulation processes in the context of ecosystem services concept. In this paper, the transfer of PTEs in soil-plant system in relatively clean environment is studied in order to assess and map the ecosystem capacity of different types of forest ecosystems to mediate toxic elements. Based on in situ observations and sampling, the PTEs concentrations in soil and aboveground vegetation were analyzed. The potential of each forest type to reduce the impact of PTEs and bioaccumulation as an indicator of ecosystem service is also discussed. The GIS analysis supports the study by creating a common database and setting the basis for ecosystem services assessment. The generated maps represent areas where the forest ecosystems have the greatest capacity to provide related ecosystem service and mediate toxic elements. The bioaccumulation of PTEs in forest territories results in medium to low rates and higher supply capacity is not present at any spatial unit as the accumulation process is focused in the soil. The obtained results highlight the ecological importance of soil in terms of acting as a buffer against pollution, especially in areas with intensive road traffic.Rheumatoid arthritis (RA) is an autoimmune disease that is currently incurable. Inhibition of inflammation can prevent the deterioration of RA. 2-[(Aminocarbonyl)amino]-5-(4-fluorophenyl)-3-thiophenecarboxamide (TPCA-1) suppresses inflammation via the inhibition of nuclear factor-κ (NF-κB) signaling pathway. Gold-based therapies have been used to treat inflammatory arthritis since the 1940s. Hyaluronic acid (HA) is a targeting ligand for CD44 receptors overexpressed on activated macrophages. Therefore, a combined therapy based on TPCA-1, gold, and HA was explored for the treatment of RA in this study. We used gold nanocages (AuNCs) to load TPCA-1 and modified the TPCA-1 (T) loaded AuNCs with HA and peptides (P) to construct an anti-inflammatory nanoparticle (HA-AuNCs/T/P). An adjuvant-induced arthritis (AIA) mice model was used to investigate the in vivo anti-inflammatory efficacy of HA-AuNCs/T/P. In vivo distribution results showed that HA-AuNCs/T/P had increased and prolonged accumulation at the inflamed paws of AIA mice.