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Hallermann-Streiff syndrome is a rare congenital disorder characterized by a wide spectrum of craniofacial abnormalities. A review of the available literature reveals that only approximately 200 cases of the disease have been reported worldwide. For this article, we performed a literature review as a basis for a proposed scheme for early care and treatment. A comprehensive database search was carried out with the use of Medline (PubMed), ISI Web of Science, and ScienceDirect/Scopus. Of the 551 studies initially found, an evaluation using inclusion and exclusion criteria ultimately resulted in a total of 33 articles. Most of the articles are case reports, and only approximately 20% of these articles include treatment options. We propose an early care and treatment schedule based on the presented symptoms. [Pediatr Ann. 2021;50(5)e227-e231.].The soil is the part of the biosphere where heavy metal pollution is most common. Heavy metals pose a threat to animal and human health through plants. This study aimed to evaluate heavy metal concentrations in the soil of orchards of Bilecik Province and possible human health risks. In 2016, 42 soil samples were taken from peach orchards of Bilecik Province, and Cr, Fe, Ni, Cu, Zn, Cd, and Pb analyzed. Pollution indices (Enrichment Factor, Geoaccumalation Index, Contamination Factor, Ecological Risk Factor) were used to determine heavy metal pollution, and the effects on human health were determined by the hazard quotient (HQ) and hazard index (HI). The study area is moderate contaminated by Cd (3.64), Ni (2.38) and Cu (2.24) in terms of enrichment factor. Similarly, the study area soils were moderately contaminated by Cd (1.72), Ni (1.40) and Cu (1.38) in terms of the contamination factor. Besides, soils had moderate potential ecological risk by Cd (51.54). The principal component and correlation analysis showed Cd and Cu are anthropogenic and Ni is the lithogenic origin. Although soil pollution indexes show moderate pollution, there is no non-carcinogenic health risk for children (0.56) and adults (0.061).Phytochemical investigation on the whole plant of Chloranthus multistachys pei (Chloranthaceae) afforded three pairs of new sesquiterpene enantiomers (+)/(-)-chlorantene M [(+)/(-)-1], (+)/(-)-chlorantene M1 [(+)/(-)-2] and (+)/(-)-chlorantene N [(+)/(-)-3]. The structures of new compounds were determined through spectroscopic techniques (HR-ESI-MS, 1 D and 2 D NMR), besides, their absolute and relative configurations were established by using Single-crystal X-ray diffraction analysis and CD spectrum. The anti-inflammatory potential of all compounds was evaluated by applying LPS induced RAW 264.7 macrophage inflammatory model, and the results were that none of these compounds showed activity (IC50 > 100 μM).

To summarize the indications and outcomes of posterior chamber phakic intraocular lens (PIOL) implantation in corneal ectasias including keratoconus, pellucid marginal degeneration (PMD), post-refractive surgery, and post-keratoplasty ectasias.

A review of the literature was conducted using the relevant keywords from various databases up to August 15, 2020. All pertinent studies were reviewed, and the relevant articles were studied in detail for efficacy, stability, predictability, and safety outcomes. In addition, visual quality, corneal biomechanical outcomes, complications, the role of posterior chamber PIOL in combination treatment, and comparison of posterior chamber PIOL with other PIOLs for ectasias were also evaluated.

A total of 30 relevant studies (13 prospective, 13 retrospective, 4 case reports) on the subject were studied and summarized. All studies showed a favorable refractive outcome. Quality of vision remained unaffected and no significant complications were reported in any of the studies.

Posterior chamber PIOLs represent a viable option in the treatment of mild to moderate and stable corneal ectasia in patients with contact lens intolerance who have low irregular astigmatism, a clear central cornea, and good preoperative corrected distance visual acuity.

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Posterior chamber PIOLs represent a viable option in the treatment of mild to moderate and stable corneal ectasia in patients with contact lens intolerance who have low irregular astigmatism, a clear central cornea, and good preoperative corrected distance visual acuity. [J Refract Surg. 2021;37(5)351-359.].

To compare different new-generation biometric formulas and ray-tracing for small-aperture intraocular lens (IOL) (IC-8; Acufocus, Inc) implantation in patients undergoing cataract and refractive lens exchange surgery with highly irregular corneas.

This monocenter study included 17 eyes of 17 patients with highly irregular corneas of different genesis. Biometric and topographic corneal data were assessed using the IOLMaster 700 (Carl Zeiss Meditec) and Pentacam (Oculus Optkigeräte GmbH). Prediction and absolute error were compared after 3 months based on manifest refraction. Furthermore, change of total corneal refractive power in different corneal pathologies was also evaluated. For IOL power calculation, three fourth-generation IOL formulas were compared (Haigis, SRK-T, and Barrett Universal II). The dataset was then checked against ray-tracing and analyzed to improve prediction error in these highly irregular corneas.

All patients showed an improvement in visual acuity postoperatively with a mean sphein the patient group. Ray-tracing confirmed the results of biometric formulas up to a keratometric value of 48.00 D and should be compared with standard biometric formulas to address corneal irregularities and to minimize refractive surprises after surgery. A comparison with ray-tracing in eyes with a keratometric value of greater than 48.00 D should not be considered due to the inaccurate results. [J Refract Surg. 2021;37(5)312-317.].

To investigate the relationship between severity of myopia and corneal deformation characteristics after removing confounding factors using propensity score matching (PSM) analysis.

A prospective study was conducted from April 1 to December 30, 2019 in Tianjin Eye Hospital. click here Participants were divided into low (spherical equivalent [SE] > -6.00 diopters) and high (SE ⩽ -6.00 diopters) myopia groups. Corneal deformation parameters were obtained using corneal visualization Scheimpflug technology. PSM analysis was conducted to minimize the effect of confounding factors (age, intraocular pressure, and corneal thickness) on corneal deformation. Correlation analysis and logistic regression models were applied to investigate the relationships between SE and corneal deformation parameters.

A total of 2,126 eyes from 1,063 patients with a mean age of 23.81 ± 5.68 years were enrolled. The left and right eyes were analyzed separately. After PSM analysis, logistic regression indicated that the peak distance was a significant indicator for high myopia in both eye models (left odds ratio [OR] = 1.978, 95% CI 1.303 to 3.004; right OR = 2.089, 95% CI 1.362 to 3.202;

< .001). The maximum amplitudes of deformation and deflection and peak distance were significantly negatively correlated with SE in both eyes, whereas the whole eye movement was significantly positively correlated with SE (

< .01), as well as the deformation amplitude at the second applanation (

< .001).

Eyes with high myopia exhibited larger deformation and deflection amplitude compared to eyes with low myopia. The high distance between bending points of the cornea at the highest concavity (peak distance) may be a feature of high myopia.

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Eyes with high myopia exhibited larger deformation and deflection amplitude compared to eyes with low myopia. The high distance between bending points of the cornea at the highest concavity (peak distance) may be a feature of high myopia. [J Refract Surg. 2021;37(5)344-350.].

To explore the relationship between the change in intraocular lens (IOL) position and capsular bend after cataract surgery.

Patients underwent phacoemulsification and IOL implantation (Alcon Laboratories, Inc). Patients were divided into two groups based on preoperative axial length long axial length group (axial length ⩾ 26 mm) and normal axial length group (axial length > 22 but < 26 mm). Swept-source optical coherence tomography was performed at 1 day, 1 week, 1 month, and 3 months after mydriasis to obtain postoperative aqueous depth (PAD) and capsular bend index (CBI). The relationship between CBI and PAD changes was analyzed.

Eighty patients (80 eyes) were included in the study. PAD decreased gradually from 1 day to 1 week and increased from 1 week to 3 months. Mean CBI was moderately positively correlated with PAD changes (

= 0.586,

< .001). The IOL moved forward gradually when the CBI was less than 2.30 and the IOL gradually moved backward when the CBI was 2.30 or greater. The root mean square of the change in PAD was smaller in the long axial length group (0.08 ± 0.04 mm) than in the normal axial length group (0.09 ± 0.05 mm) during the 3 months after surgery (

= .036).

The position of the IOL was almost stable 1 month after operation, and postoperative capsule adhesion mainly occurred within 1 month. The change in PAD was related to capsule adhesion. The postoperative position of the IOL was relatively stable and capsular bend was relatively slow for the long axial length group over 3 months.

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The position of the IOL was almost stable 1 month after operation, and postoperative capsule adhesion mainly occurred within 1 month. The change in PAD was related to capsule adhesion. The postoperative position of the IOL was relatively stable and capsular bend was relatively slow for the long axial length group over 3 months. [J Refract Surg. 2021;37(5)324-330.].

To establish a simple clinical method of predicting addition power achieved with a multifocal intraocular lens (IOL).

In this prospective cohort study, 41 patients were bilaterally implanted with the Bi-Flex MY multifocal IOL (Medicontur) with +3.50 diopters (D) near addition power. Monocular defocus curves were plotted for each patient and effective addition power was calculated as the dioptric difference between the distance and near inflection points of the defocus curve. Six biometry formulas (Haigis, Holladay, SRK/T, Hill RBF, Barrett Universal II, and Holladay 2) were used to predict the addition power at the spectacle plane.

Mean effective addition power was 2.60 ± 0.29 D, with significant (

< .01) differences between the prediction methods. Significant differences were found between predicted and effective addition when the Holladay, SRK/T, Hill RBF, and Holladay 2 formulas were used. A moderate but significant correlation (

= 0.342,

= .033) was found with the Barrett formula, and this was also the method to show the least proportional bias with Bland-Altman analysis.

The study demonstrates that the effective addition power can be predicted using the proposed simple clinical method derived using the Barrett Universal II formula. The proposed technique may have significant clinical value in screening for patients where ocular biometry may lead to aberrant addition power.

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The study demonstrates that the effective addition power can be predicted using the proposed simple clinical method derived using the Barrett Universal II formula. The proposed technique may have significant clinical value in screening for patients where ocular biometry may lead to aberrant addition power. [J Refract Surg. 2021;37(5)318-323.].