Behrensemerson6431

Theories can be represented as statistical models for empirical testing. this website There is a vast literature on model selection and multimodel inference that focuses on how to assess which statistical model, and therefore which theory, best fits the available data. For example, given some data, one can compare models on various information criterion or other fit statistics. However, what these indices fail to capture is the full range of counterfactuals. That is, some models may fit the given data better not because they represent a more correct theory, but simply because these models have more fit propensity-a tendency to fit a wider range of data, even nonsensical data, better. Current approaches fall short in considering the principle of parsimony (Occam's Razor), often equating it with the number of model parameters. Here we offer a toolkit for researchers to better study and understand parsimony through the fit propensity of structural equation models. We provide an R package (ockhamSEM) built on the popular lavaan package. To illustrate the importance of evaluating fit propensity, we use ockhamSEM to investigate the factor structure of the Rosenberg Self-Esteem Scale. (PsycInfo Database Record (c) 2021 APA, all rights reserved).

The reduction of goal-directed behavior, termed apathy, is a pervasive and debilitating syndrome after traumatic brain injury (TBI). link2 However, understanding of apathy as a multifaceted construct is limited, especially in Southeast Asian nations. This study aimed to investigate the severity, insight, and psychosocial influences of apathy in executive, emotional, and initiation dimensions in Vietnam-a country with high prevalence of TBI.

One hundred and eleven Vietnamese participants (61 individuals with moderate to severe TBI and 50 healthy controls) and their informants completed the self-rated and informant-rated Dimensional Apathy Scale (DAS) for the assessment of executive, emotional, and initiation apathy severity. Insight of apathy was calculated by subtracting DAS self-ratings from informant ratings. Additionally, carers completed measures assessing psychosocial factors of overall family health and overprotective behavior, while participants rated their own self-efficacy.

Our results showed greatersymptom-specific approaches in clinical practice. (PsycInfo Database Record (c) 2021 APA, all rights reserved).

This study investigates how spatial working memory skills, and the processing and retrieval of distal auditory spatial information are influenced by visual experience.

We developed an experimental paradigm using an acoustic simulation. The performance of congenitally blind and sighted participants (

= 9 per group) was compared when recalling sequences of spatialised auditory items in the same or reverse order of presentation. Two experimental conditions based on stimuli features were tested non-semantic and semantic.

Blind participants had a shorter memory span in the backward than the forward order of presentation. In contrast, sighted participants did not, revealing that blindness affects spatial information processing with greater executive source involvement. Furthermore, we found that blind subjects performed worse overall than the sighted group and that the semantic information significantly improved the performance, regardless of the experimental group and the sequences' order of presentation.

Lack of early visual experience affects the ability to encode the surrounding space. Congenital blindness influences the processing and retrieval of spatial auditory items, suggesting that visual experience plays a pivotal role in calibrating spatial memory abilities using the remaining sensory modalities. (PsycInfo Database Record (c) 2021 APA, all rights reserved).

Lack of early visual experience affects the ability to encode the surrounding space. Congenital blindness influences the processing and retrieval of spatial auditory items, suggesting that visual experience plays a pivotal role in calibrating spatial memory abilities using the remaining sensory modalities. (PsycInfo Database Record (c) 2021 APA, all rights reserved).

Prism adaptation was shown to modify auditory perception. link3 Using a dichotic listening task, which assesses auditory divided attention, benefits of a rightward prism adaptation were demonstrated in neglect patients (i.e., a syndrome following right hemisphere brain damage) by reducing their left auditory extinction. It is currently unknown whether prism adaptation affects auditory divided attention in healthy subjects. In the present study, we investigated the aftereffects of prism adaptation on dichotic listening.

A sample of 47 young adults performed a dichotic listening task, in which pairs of words were presented with two words sounded simultaneously, one in each ear. Three parameters were measured The percentage of recalled words, the percentage of correctly recalled words, and the laterality index (LI).

Prism adaptation to a leftward optical deviation (L-PA) significantly increased the overall percentage of recalled words (

= .044) and that from the right ear (

= .002), and the overall LI (

= ory rehabilitation requiring a modulation of auditory attention. (PsycInfo Database Record (c) 2021 APA, all rights reserved).The classic neurotransmitter γ-aminobutyric acid (GABA) has been shown to shape the activation and function of immune cells. There are four high-affinity GABA transporters (GATs, including GAT-1, GAT-2, GAT-3, and GAT-4) responsible for the transmembrane transport of GABA in mice. To explore the effect of GAT-2 on type 1 helper T (Th1) cells, naïve CD4+ T cells were isolated from splenocytes of GAT-2 knockout (KO) and wild-type (WT) mice and cultured for Th1 cell differentiation, and then, metabolomics analysis of Th1 cells was performed via gas chromatography coupled to time-of-flight mass spectrometry added with multivariate analyses. Based on the variable importance projection value > 1 and P less then 0.05, a total of nine differentially expressed metabolites (DEMs) were identified between WT and KO. Then, DEMs were mapped to the KEGG database, and five metabolic pathways were significantly enriched, including the cysteine and methionine metabolism, the riboflavin metabolism, the purine metabolism, the glycerolipid metabolism, and the glycerophospholipid metabolism. Collectively, our metabolomics analysis revealed that deficiency of GAT-2 influenced the metabolomics profile of Th1 cells, which will provide insights into T cell response to GAT-2 deficiency in mice. Data are available via MetaboLights with identifier MTBLS3358.We examine the formation and growth of isolated myelin figures and microscale multilamellar tubules from isotropic micellar solutions of an anionic surfactant. Upon cooling, surfactant micelles transform into multilamellar vesicles (MLVs) whose contact is found to trigger the unidirectional growth of myelins. While the MLV diameter grows as dMLV ∝ t1/2, myelins grow linearly in time as LM ∝ t1, with a fixed diameter. Combining time-resolved small-angle neutron scattering (SANS) and optical microscopy, we demonstrate that the microscopic growth of spherical MLVs and cylindrical myelins stems from the same nanoscale molecular mechanism, namely, the surfactant exchange from micelles into curved lamellar structures at a constant volumetric rate. This mechanism successfully describes the growth rate of (nonequilibrium) myelin figures based on a population balance at thermodynamic equilibrium.Assembly of nanoscale objects into linear architectures resembling molecular polymers is a basic organization resulting from divalent interactions. Such linear architectures occur for particles with two binding patches on opposite sides, known as Janus particles. However, unlike molecular systems where valence bonds can be envisioned as pointlike interactions nanoscale patches are often realized through multiple molecular linkages. The relationship between the characteristics of these linkages, the resulting interpatch connectivity, and assembly morphology is not well-explored. Here, we investigate assembly behavior of model divalent nanomonomers, DNA nanocuboid with tailorable multilinking bonds. Our study reveals that the characteristics of individual molecular linkages and their collective properties have a profound effect on nanomonomer reactivity and resulting morphologies. Beyond linear nanopolymers, a common signature of divalent nanomonomers, we observe an effective valence increase as linkages lengthened, leading to the nanopolymer bundling. The experimental findings are rationalized by molecular dynamics simulations.A weakly coordinated carboxylate-directed palladium-catalyzed atroposelective C-H alkynylation method for the development of novel axially chiral styrene-type carboxylic acids is disclosed. This transformation exhibits good yields (up to 85%), excellent enantiocontrol (up to 99% ee), and mild conditions. Notably, the synthetic utility of the resulting alkynyl carboxylic acid derivatives was demonstrated by various derivatizations as well as their potential as chiral ligands in asymmetric C-H activations.Enzyme-based systems have been shown to undergo chemotactic motion in response to their substrate gradient. This phenomenon has been exploited to direct the motion of enzymes and enzyme-attached particles to specific locations in space. Here, we propose a new kinetic model to analyze the directional movement of an ensemble of protein molecules in response to a gradient of the ligand. We also formulate a separate model to probe the motion of enzyme molecules in response to a gradient of the substrate under catalytic conditions. The only input for the new enzymatic model is the Michaelis-Menten constant which is the relevant measurable constant for enzymatic reactions. We show how our model differs from previously proposed models in a significant manner. For both binding and catalytic reactions, a net movement up the ligand/substrate gradient is predicted when the diffusivity of the ligand/substrate-bound protein is lower than that of the unbound protein (positive chemotaxis). Conversely, movement down the ligand/substrate gradient is expected when the diffusivity of the ligand/substrate-bound protein is higher than that of the unbound protein (negative chemotaxis). However, there is no net movement of protein/enzyme when the diffusivities of the bound and free species are equal. The work underscores the critical importance of measuring the diffusivity of the bound protein and comparing it with that of the free protein.To understand corrosion, energy storage, (electro)catalysis, etc., obtaining chemical information on the solid-liquid interface is crucial but remains extremely challenging. Here, X-ray absorption spectroscopy (XAS) is used to study the solid-liquid interface between TiO2 and H2O. A thin film (6.7 nm) of TiO2 is deposited on an X-ray-transparent SiNx window, acting as the working electrode in a three-electrode flow cell. The spectra are collected based on the electron emission resulting from the decay of the X-ray-induced core-hole-excited atoms, which we show is sensitive to the solid-liquid interface within a few nm. The drain currents measured at the working and counter electrodes are identical but of opposite sign. With this method, we found that the water layer next to anatase is spectroscopically similar to ice. This result highlights the potential of electron-yield XAS to obtain chemical and structural information with a high sensitivity for the species at the electrode-electrolyte interface.