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We present an unusual technique for reconstruction of a postoperative tissue defect following hallux rigidus surgery.

A complicated course after left big toe arthrodesis resulted in a soft tissue defect with bone exposure of the first ray. Amputation of the big toe was categorically rejected by the patient. There was advanced arteriosclerosis with single-vessel supply to the foot via the posterior tibial artery.

To preserve the big toe, the defect was covered by a fasciocutaneous radial free flap with a 15 cm long vascular pedicle which was microanastomosed to the posterior tibial artery and its accompanying vein at the level of the medial malleolus.

In certain extreme situations, the free "Chinese" radial flap can be quite effective in covering forefoot defects and allowing satisfactory and aesthetically pleasing soft tissue reconstruction.

In certain extreme situations, the free "Chinese" radial flap can be quite effective in covering forefoot defects and allowing satisfactory and aesthetically pleasing soft tissue reconstruction.

Since 2014 outcome data for the treatment of very low birth weight (VLBW) infants in Germany have been available at www.perinatalzentren.org. This study explores the relationship between volume of VLBW infants and outcome.

Volumes of VLBW infants for each perinatal centre are available for the 5-year period from 2014 to 2018, and survival and survival without severe morbidity in relation to the national average survival rate is reported. In addition to volume an adjusted volume is specified considering several risk factors. Using regression, the relationship between volume, adjusted volume and survival was investigated.

Of 212 perinatal centres 163 (77%) were level 1 centres (highest level in Germany) and 49 (23%) were level 2 centres caring for 9300 (94%; median 51; min 13 max 186) and 538 (6%; 9; 4-28) VLBW infants per year, respectively. No significant correlation between volume and survival and survival w/o severe morbidity was found. Adjusted volumes showed a weak linear correlation to survival w/o severe morbidity (p=0.02, R2=0.03). Non-parametric regression was significant for adjusted volumes of more than 170 (survival) and 100 (survival w/o severe morbidity) VLBW infants per year and centre, respectively. Below these limits volume does not affect variation.

Linear and non-linear regression between adjusted volumes and survival was only weak and was driven by the very large perinatal centres.

Linear and non-linear regression between adjusted volumes and survival was only weak and was driven by the very large perinatal centres.

Caesarean rates have increased rapidly for various reasons recently. One of the important reasons among these is medicolegal problems. Our aim with this study was to preoperatively predict abdominal adhesion density by combining the scar tissue morphology formed in the post-caesarean Pfannenstiel incision line and the skin color scoring of the patients.

Patients who had undergone one caesarean section previously, completed their terms (37-39 weeks) and were under 35 years old were included in the study. Skin color scoring of the patients was performed using the Fitzpatrick skin color scale. Intra-abdominal adhesion scoring of the participant patients was performed using Nair's adhesion scoring system.

The change in abdominal adhesion scores was evaluated based on the Fitzpatrick color scale. Adhesion scores per the Nair intra-abdominal adhesion scoring system were found to be 0.04±0.209 in the FP1 group, 0.35±0.662 in the FP2 group, 1.58±0.923 in the FP3 group, and 2.33±0.577 in the FP4 group (p<0.05ombination of these two parameters may be more effective in predicting intra-abdominal adhesions. Nevertheless, there is a need for studies with a much higher number of patients and multiple parameters to be able to predict intra-abdominal adhesion density preoperatively with greater accuracy.

Many pediatric cancer centers still use Gentamicin as first line combination treatment in patients with fever and neutropenia. Since 2011, our center has implemented a dosing regimen with 250 mg/m

BSA (max. 10 mg/kg, max. 400 mg) as a single daily infusion according to the German guideline.

In this prospective audit (February 2011 to December 2019), 105 Gentamicin treatment cycles were analyzed in 66 pediatric cancer patients, focusing on adherence to the dosing regimen and the drug monitoring results.

Adherence to the dosing regimen was high (89%). In 64% of all cycles, the C

(drawn 1 h after the 2

dose) reached the target of 10-20 µg/ml. C

significantly correlated with dosing in mg/m

BSA (p=0,007), but not with dosing in mg/kg (p=0,366). Age below 6 years did not influence these results. The Gentamicin C

(drawn 8-10 h after the second dose) was < 2 µg/ml in 93% of all cycles without any dose correlation. None of the patients experienced Gentamicin-associated nephrotoxicity.

This prospective audit of single daily infusion Gentamicin in pediatric cancer patients without impaired renal function elicits the feasibility and safety of the dosing regimen in mg/m

BSA according to the German guideline. Since indications for first-line gentamicin are limited, a multicenter prospective study would be advantageous to confirm these observations.

This prospective audit of single daily infusion Gentamicin in pediatric cancer patients without impaired renal function elicits the feasibility and safety of the dosing regimen in mg/m2 BSA according to the German guideline. Since indications for first-line gentamicin are limited, a multicenter prospective study would be advantageous to confirm these observations.

Cystic fibrosis (CF) is a multisystemic disease that prevalently involves the lungs. Hypoxemia occurs due to the existing of progressive damage to the pulmonary parenchyma and pulmonary vessels. The condition may cause systolic and diastolic dysfunction to the right ventricle due to the effects of high pulmonary artery systolic pressure (PASP). The study aimed to determine echocardiographic alterations in PASP, right ventricle (RV) anatomy, and functions in mild CF children.

RV anatomy, systolic, and diastolic functions were evaluated with conventional echocardiographic measurements. Estimated PASP was used measured with new echocardiographic modalities, including pulmonary artery acceleration time (PAAT), right ventricular ejection time (RVET), and their ratio (PAAT/RVET). The obtained echocardiographic data were statistically compared between the patient group and the control group.

The study consisted of 30 pediatric patients with mild CF and 30 healthy children with similar demographics. Bevacizumab nmr In patient group, conventional parameters disclosed differences in RV anatomy, both systolic and diastolic functions of RV compared with the healthy group.