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effects are less with the 2-lead system. Registration URL https//www.clinicaltrials.gov; Unique identifier NCT03339310.BACKGROUND The NuPulseCV intravascular ventricular assist system (iVAS) provides extended duration ambulatory counterpulsation via a durable pump placed through the distal subclavian artery. METHODS We performed a prospective, single-arm, multicenter, US Food and Drug Administration-approved feasibility trial of iVAS therapy as a bridge to transplant or decision following the FIH (First-In-Human) trial. selleck chemicals RESULTS Forty-seven patients were enrolled, and 45 patients (median 61 years old, 37 males, and 30 listed on United Network of Organ Sharing) received iVAS support for median 44 (25-87) days. There were no intraoperative complications. Success was defined as survival or transplant on iVAS therapy free from disabling stroke. Outcome success at 30 days (the primary end point of this study) and at 6 months was 89% and 80%, respectively. During 6 months of iVAS support, 2 patients died and 2 patients experienced disabling neurological dysfunction. Six-minute walk distance, 2-minute step test, and Kansas City Cardiomyopathy Questionnaire score improved during 4-week iVAS support. CONCLUSIONS This feasibility trial demonstrated promising short-term outcomes of iVAS therapy with improved functional capacity and quality of life during the therapy. Registration URL http//www.clinicaltrials.gov. Unique identifier NCT02645539.In their recent paper, Forbes et al. (2019; FWMK) evaluate the replicability of network models in two studies. They identify considerable replicability issues, concluding that "current 'state-of-the-art' methods in the psychopathology network literature […] are not well-suited to analyzing the structure of the relationships between individual symptoms". Such strong claims require strong evidence, which the authors do not provide. FWMK identify low replicability by analyzing point estimates of networks; contrast low replicability with results of two statistical tests that indicate higher replicability, and conclude that these tests are problematic. We make four points. First, statistical tests are superior to the visual inspection of point estimates, because tests take into account sampling variability. Second, FWMK misinterpret the statistical tests in several important ways. Third, FWMK did not follow established recommendations when estimating networks in their first study, underestimating replicability. Fourth, FWMK draw conclusions about methodology, which does not follow from investigations of data, and requires investigations of methodology. Overall, we show that the "poor replicability "observed by FWMK occurs due to sampling variability and use of suboptimal methods. We conclude by discussing important recent simulation work that guides researchers to use models appropriate for their data, such as nonregularized estimation routines.PURPOSE The aims of this study were to compare the biometric parameters and axial lengths of eyes with phacomorphic glaucoma and mature cataract and to identify differences that might predispose to development of phacomorphic glaucoma. METHODS Three hundred forty-two patients were enrolled in this retrospective study. The eyes were divided into four groups-Group (G)1 phacomorphic glaucoma (n = 29), G2 mature cataract (n = 313), G3 contralateral phacomorphic glaucoma (n = 29), and G4 contralateral mature cataract (n = 313). Central corneal thickness and anterior chamber depth were assessed by optical low-coherence reflectometry (Lenstar LS 900®; Haag-Streit AG, Switzerland), while axial length was determined by A-scan ultrasound biometry. RESULTS The mean central corneal thickness of G1 was significantly higher than in other groups (p  less then  0.001) and the mean anterior chamber depth of G1 was the lowest among the groups (p  less then  0.001). Also, G2 had lower mean anterior chamber depth than G4 (p  less then  0.001) and G3 had lower mean anterior chamber depth than G4 (p = 0.007). Anterior chamber depth less than 3.27 mm had the higher odds ratio for distinguishing G3 versus G4 (odds ratio = 10.79, p  less then  0.001). Furthermore, patients aged ⩾68.9 years had the higher odds ratio for distinguishing G1 versus G2 (odds ratio = 2.82, p = 0.019). There was no significant difference in the presence of pseudoexfoliation material between G1 and G2 (p = 0.057). There were no significant differences in axial length values among the four groups (p = 0.097). CONCLUSION Advanced age and shallow anterior chamber depth were found to be risk factors for developing phacomorphic glaucoma, but the presence of pseudoexfoliation material was not found to play a role as a risk factor in phacomorphic glaucoma development.Adenosquamous carcinoma of the head and neck is a rare cancer associated with poor prognosis. Histologically, it is identified through the presence of both adenocarcinoma and squamous cell carcinoma, although it may be difficult to diagnose from initial endoscopic biopsies. We report a case of adenosquamous carcinoma of the glottis in an 82-year-old female patient who presented with progressive hoarseness of voice and in whom initial biopsies had shown only moderate to severe dysplasia. This is the first case in the literature of a primary adenosquamous carcinoma of the glottis managed successfully with a CO2 laser left type Va cordectomy. The patient remained disease-free 28 months postoperatively.Africa has the highest rates of child mortality and diseases in the world. Research suggests that sport can be an effective way to enhance health knowledge and behaviors among at-risk youth in Africa. Scoping reviews explore both the breadth and depth of a research topic, which allows researchers to conduct a detailed analysis and synthesis of studies to understand how, why, and under what circumstances sport-based interventions are effective. The purpose of this scoping review was to specifically examine the study design, theoretical foundations, sample characteristics, measured and observed outcomes, intervention characteristics, and funding sources identified in previous studies that examined sport as a platform for health promotion with youth in Africa. A total of 916 articles were retrieved from 10 electronic bibliographic databases; 28 studies met the inclusion criteria. Of these, four were randomized controlled trials, while the remaining were open trials with pre-posttest assessments, both with comparison conditions and without. Only 10 studies included a theoretical framework to specifically inform the sport-based intervention implemented. Targeted health outcomes included knowledge and behaviors related to a myriad physical and mental health concerns, such as HIV, clean water use, vaccinations, physical activity, and fitness. Statistically significant improvements were observed in 82% of the studies examined. Our results suggest that sport-based interventions may be effective in improving health knowledge and behaviors among youth in Africa. Recommendations for future research, including methodology and the importance of global partnerships with nonprofit organizations, are discussed.PURPOSE The purpose of the study was to demonstrate whether photodynamic therapy in patients with acute central serous chorioretinopathy, with the leakage point within one optic disk diameter from the fovea, can be safely deferred. METHODS A single-center, randomized, controlled trial was conducted. Patients were randomized to photodynamic therapy within a week after presentation (Group I, 26 patients) or observation during 3 months (Group II, 26 patients). If leakage or subretinal fluid was observed during any control visit, photodynamic therapy was performed (again) within a week. PRIMARY OUTCOME Primary outcome was change of visual acuity (Early Treatment Diabetic Retinopathy Study) after 12 months. Secondary outcomes were visual acuity, central foveal thickness, metamorphopsia, and color discrimination. RESULTS Photodynamic therapy procedures group I, 26 at baseline, 2 retreatments at 3 months; group II, 10 at 3 months, 1 at 6 months (2 subjects refusing treatment), 2 retreatments at 6 months. At 12 months, mean visual acuity of all patients had improved by 6.5 letters (P  less then  0.001), mean central foveal thickness was 172 µm less (P  less then  0.001). After photodynamic therapy, visual acuity recovered faster and metamorphopsia significantly improved (3 months, P  less then  0.001). Differences between groups at 12 months were not significant. CONCLUSION The (intended) number of photodynamic therapy (re)treatments in group II (n = 15) was 46% less than in group I (n = 28). Visual acuity and central foveal thickness at 12 months were similar. Therefore, the preferred management of acute central serous chorioretinopathy at presentation appears to be observation for 3 months.Recently, repeated childhood vaccine scandals shook public confidence in vaccine safety in China. This study explores whether media attention, online discussion, and social trust influence Chinese parents' risk perception and vaccination intention. Based on data from a Qualtrics panel (N = 354), results indicate that media attention is positively related to social trust and online discussion is positively related to perceived benefits. Additionally, social trust is negatively associated with perceived risk but positively associated with perceived benefits. Social trust is also positively related to general vaccination intention and intention to get domestic vaccines. Further, social trust mediates the relationship between media attention/online discussion and risk perception. Lastly, parents with higher risk perception are less likely to get domestic vaccines, but more likely to get imported vaccines. Perceived benefits also influence vaccination intention.The field of neuropsychology is becoming increasingly responsive to addressing the specific needs of an ever-growing Hispanic/Latinx population. As such, bilingualism and bilingual education are at the forefront of considerations for neuropsychologists. This paper examines models of bilingual academic instruction and levels of bilingualism and how they impact neuropsychological findings and diagnostic determinations in pediatrics. link2 The present case series highlights five children assessed in a pediatric medical setting. Various profiles are analyzed to highlight the intricacies in assessment that must be considered. These findings present a set of considerations as a step toward a systematic approach to bilingual neuropsychological assessment.Replacement of the insulin-secreting beta cells through transplantation of pancreatic islets to the liver is a promising treatment for type-1 diabetes. However, low oxygen tension, shear stress, and the induction of inflammation lead to significant islet dysfunction and loss. link3 The anterior chamber of the eye (ACE) has gained considerable interest and represents an alternative therapeutic islet transplantation site because of its accessibility, high oxygen tension, and immune-privileged milieu. We have previously demonstrated the feasibility of intraocular islet transplant in mouse and nonhuman primate models of type-1 diabetes and are now assessing its efficacy on glucose homeostasis in a nonhuman primate model of type-2 diabetes. We transplanted allogeneic donor islets (1,500 islet equivalents/kg) into the anterior chamber of one eye in a cynomolgus monkey with high-fat-diet-induced type-2 diabetes. Repeated examinations of the anterior and posterior segments of both eyes were done to monitor the engrafted islets and assess the overall ocular health.