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d. Key symptoms of ocular surface health improved. TRIAL REGISTRATION European Union electronic Register of Post-Authorisation Studies (EU PAS) register number, EUPAS22204.Mould infections may follow traumatic injuries, with direct fungal inoculum in the site of injury and subsequent angioinvasion, possibly resulting in tissue necrosis and systemic dissemination. The pathogenesis of mould infections following trauma injuries presents unique features compared with classical mould infections occurring in neutropenic or diabetic patients, because a large fraction of post-traumatic mould infections is observed in previously healthy individuals. Most of the published clinical experience and research on mould infections following traumatic injuries regards soldiers and infections after natural disasters. However, following trauma and soil contamination (e.g., agricultural or automotive injuries) other immunocompetent individuals may develop mould infections. In these cases, delays in correct diagnosis and treatment may occur if pertinent signs such as necrosis and absent or reduced response to antibacterial therapy are not promptly recognized. Awareness of mould infections in at-risk populations is needed to rapidly start adequate laboratory workflow and early antifungal therapy in rapidly evolving cases to improve treatment success and reduce mortality.Cefiderocol, formerly S-649266, is a first in its class, an injectable siderophore cephalosporin that combines a catechol-type siderophore and cephalosporin core with side chains similar to cefepime and ceftazidime. This structure and its unique mechanism of action confer enhanced stability against hydrolysis by many β-lactamases, including extended spectrum β-lactamases such as CTX-M, and carbapenemases such as KPC, NDM, VIM, IMP, OXA-23, OXA-48-like, OXA-51-like and OXA-58. Cefiderocol's spectrum of activity encompasses both lactose-fermenting and non-fermenting Gram-negative pathogens, including carbapenem-resistant Enterobacterales. Cefiderocol recently received US Food and Drug Administration approval for the treatment of complicated urinary tract infections, including pyelonephritis, and is currently being evaluated in phase III trials for nosocomial pneumonia and infections caused by carbapenem-resistant Gram-negative pathogens. The purpose of this article is to review existing data on the mechanism of action, microbiology, pharmacokinetics, pharmacodynamics, efficacy, and safety of cefiderocol to assist clinicians in determining its place in therapy.STUDY DESIGN Prospective radiographic study. OBJECTIVES To determine the three-dimensional (3D) changes in deformity correction with magnetically controlled growing rod (MCGR) distractions. MCGRs can achieve similar coronal plane correction as traditional growing rods. The changes in the sagittal and axial planes are unknown and should be studied as these factors reflect potential for proximal junctional kyphosis and rotational deformity. Frequent MCGR distractions may potentially improve axial plane deformities to the same extent as coronal and sagittal plane deformities. METHODS Early onset scoliosis (EOS) patients who underwent dual MCGRs with minimum 2-year follow-up were included in this study. 3D reconstructions of 6-monthly biplanar images were used to study changes in coronal, sagittal and axial planes. Changes in growth parameters (body height and arm span) were scaled to changes in coronal Cobb angles, sagittal profile (T1-12, T4-12, L1-L5, L1-S1), and rotational profile at the proximal thoracic, main thoracic and lumbar curves, and pelvic parameters (sagittal pelvic tilt, lateral pelvic tilt and pelvis rotation). RESULTS A total of 10 EOS patients were studied. The mean age at index surgery was 8.2 ± 3.0 years and mean postoperative follow-up of 34.3 ± 9.5 months. Six patients had rod exchange at mean 29.5 ± 11.8 months after initial implantation. Despite consistent gains in body height and arm span, the main changes in coronal and rotational profiles only occurred at the initial rod implantation surgery with only small changes occurring with subsequent follow-ups. Patients with higher preoperative proximal junctional angles had flattening of the sagittal plane occurring at initial surgery with early rebound. No changes in pelvic parameters were observed. CONCLUSIONS The 3D changes with MCGR are mainly observed with initial rod implantation and no significant changes are observed with distractions. The MCGR can prevent deformity progression in the axial plane. LEVEL OF EVIDENCE IV.STUDY DESIGN Cross-sectional comparative study. OBJECTIVES Evaluate prevalence and clinical relevance of an underlying pathology in painful adolescent idiopathic scoliosis (AIS) patients after a non-diagnostic history, physical examination and spinal X-ray using Magnetic Resonance Image (MRI) as diagnostic tool. Discrepancies regarding indications of routine MRI screening in painful AIS patients are multifactorial. Few studies have investigated relationship and practical importance of painful AIS with an underlying pathology by MRI. METHOD A total of 152-consecutive AIS patients complaining of back pain during a 36-month period were enrolled. All patients underwent whole-spine MRI after a non-diagnostic history, physical examination and spinal X-ray. Underlying pathologies were reported as neural and non-neural axis abnormalities based on MRI reports. Variables such as sex, age, constant or intermittent pain, night pain, back pain location (thoracic or lumbar pain), Cobb-angle and follow-up were evaluated as on must be performed by clinicians; and discussed with patients and family prior to undergo further imaging management. LEVEL OF EVIDENCE Level III.PURPOSE To evaluate the impact of proximal thoracic segment (T1-T5) on global thoracic kyphosis, as well as its influence on cervical alignment (lordotic, kyphotic or straight) in patients with adolescent idiopathic scoliosis (AIS). METHODS We conducted a retrospective study of 80 patients with AIS. see more The inclusion criteria were patients between 10 and 18 years of age with a posteroanterior (PA) and lateral full-length radiographs, excluding those subjected to surgery, orthotic treatment, with other spinal disease or with poor X-ray quality. The parameters evaluated were age, sex, pelvic incidence (PI), sacral slop (SS), pelvic tilt (PT), global sagittal balance (GSB), scoliotic curvatures (differentiated according to primary curve, lumbar modifier and sagittal modifier), cervical spine alignment, thoracic sagittal Cobb angle between T1 and T5, T5 and T12 and between T1 and T12. RESULTS In patients with AIS, the proximal sagittal thoracic Cobb segment, contrary to the distal, demonstrated a significant positive correlation with cervical spine alignment (p  less then  0.