Barlowlund3316

This study highlights the reproductive biology of Hooghly Croaker, Panna heterolepis Trewavas, 1977 which is one of the dominant fish in the Bay of Bengal (Bangladesh) based on monthly sampling of 569 female individuals from January to December 2019. We observed the effect of different environmental factors (temperature, rainfall, dissolved oxygen, and pH) on the reproduction of P. heterolepis. Measurements of each individual like total length (TL) and body weight (BW) were taken by using of measuring board and digital balance. Gonads were carefully removed through ventral dissection from females and weighed to 0.01 g accuracy. To assess the size at sexual maturity (Lm), spawning season, and its peak, the GSI (gonadosomatic index in %), MGSI (modified gonadosomatic index in %), and DI (Dobriyal index) were considered. Based on these indices, the Lm was documented 15.0 cm in TL. Moreover, L50 was predicted by logistic calculation as 15.0 cm TL. Furthermore, greater values of GSI, MGSI, and DI values denoted the spawning season as of January to July, with a peak in February. Additionally, Fulton's condition factor (KF) was significantly correlated with GSI values. In addition, GSI was statistically correlated with temperature. However, other environmental factors (rainfall, dissolved oxygen, and pH) did not show any significant relation with GSI. Finally, the outcomes of our study might be useful to carry out specific management programs for P. heterolepis in the Bay of Bengal and nearby aquatic ecosystem.Prognosis in patients with post allogeneic HCT-early relapse of acute myeloid leukemia ( less then 6 months post HCT) is dismal and response to salvage treatment is less then  20%. In addition, majority of patients at this early point are unable to withstand intensive salvage chemotherapy. We hypothesized that the combination of donor lymphocyte infusion (DLI) and venetoclax may result in increased response in this difficult to treat patient group. We retrospectively analyzed 22 patients from February 2017-December 2019, who were given the Venetoclax/DLI combination. Median age was 65 (43-75) years. There were no cases of tumor lysis syndrome. Microbiology documented infections occurred in 8 patients (36%). Majority were able to tolerate the protocol without admissions. Acute GVHD was observed in 4 (18%) patients and cGVHD was observed in 6 (27%) patients. Overall response was observed in 11 (50%) patients (CR, n = 4; CRi, n = 1; CRp, n = 4; MLFS n = 2). Median time to response was 28 (18-67) days and median cycles of venetoclax 2 [1-8] and duration of response were 135 (31-564) days. Median survival was 6.1 months (95% CI .73-11.4). Cox regression model for survival showed decreased WBC at relapse, GVHD and better performance status were associated with better survival. mTOR inhibitor These results may endorse the hypothesis that enhancing alloreactivity combined with venetoclax is safe and efficacious and should be further investigated in prospective trials.

To validate the differential stress inventory (DSI) by evaluating the objective and subjective stress differences in the five DSI types in the occupational setting.

A total of 119 German participants working as medical assistants (n = 40) or in a bank (n = 79) were recruited. They completed the Maslach Burnout Inventory-General Survey, the DSI, and wore ECG measuring devices for 24h to measure heart rate variability. The DSI was used to group people into one of five types according to how they perceived and coped with stress normal, overstressed, stress-resistant, low stress/high coping, or high stress/high coping.

The overstressed type had significantly more burnout symptoms than the other types. The high stress/high coping type also had more symptoms of emotional exhaustion and total burnout compared to the other types, while the low stress/high coping and the stress-resistant types generally had the lowest levels of burnout. There were no differences on the HRV parametersamong the DSI types.

Categorising people into types like in the DSI can help make workers aware of unhealthy stress and coping patterns before they turn into more severe pathology. Proper application and targeted preventive measures can save the individual's health and the company's budget. While the DSI picked up on differences in burnout symptoms as a long-term consequence of stress, there is evidence that it cannot pick up on short-term stress or physical stress as measured by HRV from the 24h recording.

Categorising people into types like in the DSI can help make workers aware of unhealthy stress and coping patterns before they turn into more severe pathology. Proper application and targeted preventive measures can save the individual's health and the company's budget. While the DSI picked up on differences in burnout symptoms as a long-term consequence of stress, there is evidence that it cannot pick up on short-term stress or physical stress as measured by HRV from the 24 h recording.

Insulin resistance is an important factor in the pathogenesis of polycystic ovary syndrome (PCOS), which is associated with higher risk of metabolic syndrome (MetS) and cardiovascular complications. Early atherosclerotic lesions may be diagnosed by ultrasonographic parameters brachial artery flow-mediated dilation after reactive hyperaemia (FMD) and intima-media thickness of common carotid artery (IMT). The aim of the study was to assess the relation of IMT and FMD with clinical and laboratory parameters reflecting metabolic status in young women with different PCOS phenotypes.

The study included 154 PCOS patients diagnosed with the Rotterdam criteria, divided into four phenotypes, and 113 healthy women. Laboratory analyses, transvaginal ultrasound, and IMT and FMD measurements were conducted. MetS was diagnosed with International Diabetes Federation/American Heart Association (IDF/AHA) consensus criteria.

MetS was more prevalent in PCOS patients than healthy women (14.29 vs. 5.31%; p = 0.019), with highest prevalence in phenotypes I and II (p = 0.039). IMT and FMD did not differ between PCOS patients and the controls, nor between the PCOS phenotypes. PCOS patients with MetS presented lower FMD than other PCOS patients (p = 0.018). In women with PCOS, FMD correlated with glucose and insulin concentrations in the fasting state (R = -0.33, p = 0.002; R = -0.23, p = 0.026) and at 2 h of OGTT (R = -0.29, p = 0.006; R = -0.26, p = 0.014). In patients with phenotype I, correlations were found between IMT and BMI (R = 0.45, p = 0.006) and between FMD and fasting glucose concentrations (R = -0.46, p = 0.011).

Metabolic disturbances and the diagnosis of MetS in patients with PCOS, especially in hyperandrogenic phenotypes, might be associated with alterations in IMT and FMD.

Metabolic disturbances and the diagnosis of MetS in patients with PCOS, especially in hyperandrogenic phenotypes, might be associated with alterations in IMT and FMD.