Barberkidd2974

Non-invasive estimation of cartilage material properties is useful for understanding cartilage health and creating subject-specific computational models. Bi-component T2 mapping measured using Multi-Component Driven Equilibrium Single Shot Observation of T1 and T2 (mcDESPOT) is sensitive for detecting cartilage degeneration within the human knee joint, but has not been correlated with cartilage composition and mechanical properties. Therefore, the purpose of this study was to investigate the relationship between bi-component T2 parameters measured using mcDESPOT at 3.0 T and cartilage composition and mechanical properties. Ex-vivo patellar cartilage specimens harvested from five human cadaveric knees were imaged using mcDESPOT at 3.0 T. Cartilage samples were removed from the patellae, mechanically tested to determine linear modulus and dissipated energy, and chemically tested to determine proteoglycan and collagen content. Parameter maps of single-component T2 relaxation time (T2), the T2 relaxation times of the fast relaxing macromolecular bound water component (T2F) and slow relaxing bulk water component (T2S), and the fraction of the fast relaxing macromolecular bound water component (FF) were compared to mechanical and chemical measures using linear regression. FF was significantly (p less then 0.05) correlated with energy dissipation and linear modulus. T2 was significantly (p ≤ 0.05) correlated with elastic modulus at 1 Hz and energy dissipated at all frequencies. There were no other significant (p = 0.13-0.97) correlations between mcDESPOT parameters and mechanical properties. FF was significantly (p = 0.04) correlated with proteoglycan content. There were no other significant (p = 0.19-0.92) correlations between mcDESPOT parameters and proteoglycan or collagen content. This study suggests that FF measured using mcDESPOT at 3.0 T could be used to non-invasively estimate cartilage proteoglycan content, elastic modulus, and energy dissipation.

Mean ADC has high predictive value for the presence of clinically significant prostate cancer (sPC). Measurement variability is introduced by different scanners, protocols, intra-and inter-patient variation. Internal calibration by ADC ratios can address such fluctuations however can potentially lower the biological value of quantitative ADC determination by being sensitive to deviations in reference tissue signal.

To better understand the predictive value of quantitative ADC measurements in comparison to internal reference ratios when measured in a single scanner, single protocol setup.

284 consecutive patients who underwent 3 T MRI on a single scanner followed by MRI-transrectal ultrasound fusion biopsy were included. A board-certified radiologist retrospectively reviewed all MRIs blinded to clinical information and placed regions of interest (ROI) on all focal lesions and the following reference regions normal-appearing peripheral zone (PZNL) and transition zone (TZNL), the urinary bladder (BLA), andation with ρ of -0.34, followed by ADCratioPZNL (ρ=-0.32). All ADC parameters except ADCratioLIOM (p = 0.07) were associated with sPC p<0.05). Mean ADC and ADCratioPZNL had the highest ROC AUC of all parameters (0.68). Multivariable models with mean ADC improve predictive performance.

A highly standardized single-scanner mean ADC measurement could not be improved upon using any of the single ADC ratio parameters or combinations of these parameters in predicting the aggressiveness of prostate cancer.

A highly standardized single-scanner mean ADC measurement could not be improved upon using any of the single ADC ratio parameters or combinations of these parameters in predicting the aggressiveness of prostate cancer.SYLOID® 244 has never been applied as a filler in composites with potential dental application. Therefore, the aim of research was to apply this silica in its unmodified and diazonium salt-modified forms in different mass ratios as fillers in light-cured methacrylic composites. The effectiveness of modification process was confirmed with the use of Raman spectroscopy. Methacrylic composites with the modified and unmodified SYLOID® 244, as well as unfilled resin as a control group were prepared. Their basic physicochemical properties, such as depth of cure, mass stability during incubation in saline, flexural and compressive strengths were examined. limertinib A positive effect of SYLOID® 244 modification on the properties of the examined composites was also demonstrated. The obtained results proved the high applicability of SYLOID® 244 as a filler in composites with potential dental applications.

There are limited data on the impact of coronavirus disease 2019 (COVID-19) caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) on people with multiple sclerosis (MS).

To better understand SARS-CoV-2 infection in ocrelizumab-treated people with MS.

Internal Roche/Genentech data sources Cases of COVID-19 from ongoing Roche/Genentech clinical trials and from post-marketing use of ocrelizumab until July 31, 2020 were identified and assessed using descriptive statistics. External real-world data (RWD) source An MS COVID-19 cohort and an ocrelizumab-treated MS COVID-19 cohort were identified and assessed from the OPTUM

de-identified COVID-19 electronic health record (EHR) database.

Roche/Genentech clinical trial data There were 51 (1.3%) suspected or confirmed cases of COVID-19 identified from 4,000 patients ongoing in 10 Roche/Genentech clinical trials. Of these, 26 (51%) were confirmed COVID-19 and 25 (49%) were suspected COVID-19. Sixteen (31.4%) patients were hospitalized. COVIeported from the general population and MS datasets. Risk factors known to be associated with severe COVID-19 outcomes in the general population also appear to influence COVID-19 severity in ocrelizumab-treated people with MS. Case fatality rates for ocrelizumab-treated people with MS were within published ranges for the general population and other MS cohorts.

This assessment provides evidence that COVID-19 in ocrelizumab-treated people with MS is predominantly mild to moderate in severity with most patients not requiring hospitalization; in line with data reported from the general population and MS datasets. Risk factors known to be associated with severe COVID-19 outcomes in the general population also appear to influence COVID-19 severity in ocrelizumab-treated people with MS. Case fatality rates for ocrelizumab-treated people with MS were within published ranges for the general population and other MS cohorts.

Cancer treatment in France is based on Multidisciplinary Tumor Board (MTB). In the Ile-de-France region (IDF), which includes 12 million inhabitants from Paris and the surrounding area, pediatric tumors of head and neck are discussed since 2013 in a dedicated Interregional Pediatric Multicentric MTB (IPMTB). The purpose of this study is to analyze the impact of the IDF head and neck IPMTB on the management of these tumors, 5 years after their implementation.

Retrospective study of all patient files presented in the IPMTB for a benign or malignant head-and-neck tumor, between 2013 and 2018.

A total of 679 discussions were analyzed representing 428 patients. Median age was 7.5 years (range 0-31 years). Malignant tumors represented 71% of cases, including 36% of rhabdomyosarcoma. Overall, 12% percent of the cases discussed came from centers outside of IDF. All meetings complied with multidisciplinary criteria required by French law. Proposals made during the IPMTB were followed in 86% of cases. Among the 251 proposals made by the referring teams prior to the IPMTB, 29% were secondarily modified after being discussed in the IPMTB.

Thanks to their multidisciplinarity, high number of cases discussed and usual respect of their proposals, the IPMTB have made it possible to improve the coordination between all specialties involved in the patient's management, to apply the most recent and scientifically validated protocols, and to share the knowledge of different teams concerning the management of particularly rare tumors.

Thanks to their multidisciplinarity, high number of cases discussed and usual respect of their proposals, the IPMTB have made it possible to improve the coordination between all specialties involved in the patient's management, to apply the most recent and scientifically validated protocols, and to share the knowledge of different teams concerning the management of particularly rare tumors.Physiography and land use patterns influence streams water quality by affecting non-point source (NPS) pollution process. However, each landscape factor may affect the NPS pollution process differently with the variations of the spatial scale and season. Thus, quantitative analysis of each landscape metrics scale effect and determination of the abrupt change-point in the relationship between stream water quality and the metrics is very helpful for landscape planning of water quality protection. Based on water quality monitoring data for four years in 12 sub-watersheds of a typical headwater watershed in Eastern China, we adopted regular and partial redundancy methods to quantify the spatial scale effects and seasonal dependence of various landscape metrics impact on stream water quality, and then to identify the abrupt change-point of the water quality along the gradient of landscape metrics. Results revealed that the pure effects of different categories of landscape metrics on stream water quality were in ther quality, landscape regulation should follow the scale-adaptability measures and consider the landscape thresholds, which cause abrupt changes in water quality.This work proposes a tube-in-tube membrane photoreactor, operated in a continuous-mode, to boost the efficiency of peroxydisulfate (PDS), through the photolytic (UV-C radiation) and photocatalytic (TiO2-P25) processes. This new technology can efficiently facilitate the transportation of PDS to the catalyst surface and water to be treated. The ultrafiltration tubular ceramic membrane was used as support for the TiO2-P25 and oxidant-catalyst/water contactor. Tests were performed using a synthetic solution and a municipal secondary effluent, both spiked with a pharmaceutical mix solution (paracetamol (PCT), furosemide (FRS), nimesulide (NMD), and diazepam (DZP); 200 μg L-1 of each). At steady-state regime, the UVC/S2O82-/TiO2 system, with radial PDS addition, showed the highest removal of pharmaceuticals in both matrices. Furthermore, twenty-two transformation products (TPs) were identified by applying LC-QTOF MS technique. Hence, the transformation pathways including hydroxylation in aromatic moiety by an electrophilic attack, electron transfer reactions, cleavage of C-O, C-N bond, H-abstraction and ring opening were proposed. TPs chemical structures were evaluated by in silico (Q)SAR approach using TOXTREE and EPI Suite™ software.

To examine the impact of age and underlying comorbid conditions on swallowing in elderly patients with dysphagia.

Charts of consecutive patients aged >64 studied by Videofluoroscopic swallowing study (VFSS) between 2010 and 2018 at our institution were reviewed (n=731). Patients were categorized based on age into young old (aged 65-74), older old (aged 75-84) and oldest old (aged 85+). The underlying comorbidities and VFSS results were compared between different age groups.

Dysphagia was more likely to be caused by presbyphagia (p<0.01) and dementia (p<0.0001) in the oldest old, whereas, head and neck cancers (p<0.0001) were more common in the young old cohort. In the absence of organic disease (e.g. cancer, stroke, dementia), aging was associated with prolonged oral transit time (OTT) (p<0.05) and aspiration after swallow (p<0.05). Compared to those with presbyphagia, patients with organic disease were more likely to have delayed pharyngeal swallow response (p<0.05) and aspiration during swallow (p<0.