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Like adults, children suffer from gastroparesis. AZD9291 cell line However, there are currently no validated instruments to determine the impact of gastroparesis in pediatric patients. The objective of this study was to develop the items and domains to support the content validity of the new Pediatric Quality of Life Inventory™ (PedsQL™) Gastroparesis Symptoms Module.

Patients were recruited from the National Institute of Diabetes and Digestive and Kidney Diseases Pediatric Gastroparesis Registry. The qualitative methods involved an iterative process comprising a literature review of existing questionnaires and gastroparesis clinical research, an expert review panel of pediatric gastroenterologists who provided feedback on the conceptual framework in developing the semi-structured interview, and in-depth focus interviews with six pediatric patients with gastroparesis and five of their parents (one did not participate) in developing relevant domains and item content. In the subsequent cognitive interviews phase, five additional patients with gastroparesis and their parents provided detailed feedback on item content, relevance, importance, and understandability of the domains and items.

Ten domains/scales were derived from the qualitative methods, with item content saturation achieved at 67 items, with no further themes or content identified during the final cognitive interviews. The Module is comprised of 10 individual scales measuring nausea, stomach fullness when eating, vomiting, dry heaves, heartburn and reflux, stomach pain and hurt, food and drink limits, bloating, appetite, and worry.

Our study supports the content validity of the new PedsQL™ Gastroparesis Symptoms Module. The Module field test study will be conducted in a multisite national study.

Our study supports the content validity of the new PedsQL™ Gastroparesis Symptoms Module. The Module field test study will be conducted in a multisite national study.

Familial intestinal hypocholesterolemias, such as abetalipoproteinemia, hypobetalipoproteinemia, and chylomicron retention disease, are rare genetic diseases that result in a defect in the synthesis or secretion of lipoproteins containing apolipoprotein B.In children, these conditions present with diarrhoea and growth failure, whereas adults present with neuromuscular, ophthalmological, and hepatic symptoms. Simple laboratory investigations have shown that diagnosis can be made from findings of dramatically decreased cholesterol levels, deficiencies in fat-soluble vitamins (mostly vitamin E), endoscopic findings of the characteristic white intestinal mucosa, and fat-loaded enterocytes in biopsy samples. Genetic analysis is used to confirm the diagnosis. Treatment is based on a low-fat diet with essential fatty acid supplementation, high doses of fat-soluble vitamins, and regular and life-long follow-up.The present study examines cases and literature findings of these conditions, and emphasises the need to ed regular and life-long follow-up.The present study examines cases and literature findings of these conditions, and emphasises the need to explore severe hypocholesterolemia and deficiencies in fat-soluble vitamins to not miss these rare, but easy to diagnose and treat, disorders.

To compare superior mesenteric artery (SMA) flow in premature infants with parenteral and enteral nutrition.

A prospective study was conducted on two groups of preterm infants with gestational age of 28 0/7- 36 6/7 weeks Group 1 did not qualify for early enteral feeds and received parenteral nutrition, and Group 2 received early enteral feeding. SMA peak systolic velocity (PSV), end diastolic velocity (EDV) and pulsatility index (PI) were measured using Doppler ultrasound before starting feeds at day 1 and at day 5.

The study recruited 40 infants; 20 in each group. At baseline, PSV, EDV and PI did not differ between groups. At day 5, enteral nutrition was associated with significant increases in PSV (91.53 ± 29.15 vs 65.49 ± 19.18, p = 0.003) and EDV (15.91 ± 7.01 vs 11.65 ± 5.58, p = 0.026) and a decrease in PI (1.28 ± 0.40 vs2.48 ± 0.83, p < 0.001). Regression analysis to control for confounders showed enterally fed infants to have increased PSV (aOR = 25.45; 95% CI 8.53-42.38, p = 0.004) and EDV (aOR 8.630; 95% CI 2.987-14.273, p = 004) and decreased PI (aOR = -1.133; 95% CI -1.603--0.664, p < 0.001). Infants in the parenteral nutrition group later developed more frequent feeding intolerance when compared to the enterally fed group (65% vs 15% respectively, p < 0.001).

In preterm neonates, early enteral feeding is associated with increased SMA blood flow, decreased vascular intestinal resistance, and less frequent incidence of feeding intolerance.

In preterm neonates, early enteral feeding is associated with increased SMA blood flow, decreased vascular intestinal resistance, and less frequent incidence of feeding intolerance.

Functional abdominal pain disorders (FAPD) affect approximately 13.5% of children. Pharmacotherapy is often ineffective, leaving providers and families seeking adjunctive therapies. Auriculotherapy provides treatment for pain and other symptoms, without a defined protocol for FAPD. A handheld point-finder device measuring transdermal electrical current determines active acupoints, with higher current indicating a more active acupoint. Our objectives were to determine auricular acupoint (AA) activity in FAPD and to assess participants' attitudes towards auriculotherapy.

This is a prospective double-blind study evaluating electrodermal activity of AAs in pediatric-aged female participants with FAPD compared to healthy controls (HC). Participants completed surveys regarding demographics and interest in auriculotherapy. The electrodermal assessment evaluated 20 AAs per ear using a point-finder device. Each AA current measurement was analyzed by average relative rank and median, with a median current measurement ≥50 μA considered active.

We enrolled 46 female participants, 22 FAPD (mean age 15.8 years) and 24 HC (mean age 15.4 years). In FAPD, 12/40 AAs were active, of which only 6 were also active in HC. Comparison of median current and average ranking between participants demonstrated consistency. In the post-assessment survey, 86.4% of FAPD expressed interest in receiving auricular acupressure and 68.2% would travel to clinic solely for treatment.

Based on electrodermal measurements, we propose a treatment protocol using auriculotherapy for FAPD symptom-management. We demonstrated there is considerable patient interest in auriculotherapy. Further studies are needed to confirm the findings in a larger sample size and validate the efficacy of this treatment protocol.

An infographic is available for this article athttp//links.lww.com/MPG/C322.

An infographic is available for this article athttp//links.lww.com/MPG/C322.