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In mice-fed SO, lipid accumulation was predominately in adipose tissue, accompanied a tendency decrease in insulin sensitivity. Mice-fed OO had lower plasma triglycerides (TG) and increased hepatic CD36 gene expression. The C-PO group presented lower messenger RNA (mRNA) levels in the liver for all examined genes SREBP-1c, FAS, G6Pase, and CD36. There were no significant differences in weight gain, plasma cholesterol and high-density lipoprotein (HDL) cholesterol levels, hepatic ACC, SIRT1, AMPK, and CD36 protein levels or in liver function among the diets.

It seems that as long as fat is consumed in moderation, oil types may play a lesser role in the metabolism of healthy individuals.

This finding has the potential to increase flexibility in choosing oil types for consumption.

This finding has the potential to increase flexibility in choosing oil types for consumption.

Parental feeding practices and family meals are important determinants for infants' diet and health. Still, there is no previous research of the association between feeding practices and family meals in infants.

Explore potential associations between feeding practices and family meals among infants.

We present cross-sectional results (baseline) from the Food4toddlers study. In total 298 parents of 1-year-olds, recruited from all over Norway, filled in a questionnaire regarding frequency of shared family meals (breakfast, lunch, dinner) and feeding practices using the validated instrument Comprehensive Feeding Practices Questionnaire. Logistic regression was used to explore the associations between having family meals every day and feeding practices (10 dimensions).

The children included were about 11 months old, and 55% were boys. Parents were highly educated. Most children had family breakfast and dinner (60-65%), while fewer had family lunch every day (35%). We found that eating family breakfast and associated with negative feeding practices. Shared family meals provide an important setting for healthy eating, development of feeding skills and dietary habits formation.

As the world increasingly looks to renewable energy sources to deal with climate change, South Korea is aiming to become a leader in the development of hydrogen as an alternative energy source. In developing an ecosystem for a hydrogen economy, South Korea is focused on increasing the production and use of hydrogen vehicles, establishing an ecosystem for the production and distribution of hydrogen and related technologies, and expanding the production of fuel cells. The government's vision has the backing of key industrial firms, most importantly the Hyundai Motors Group which plans on investing 7.6 trillion won ($6.7 billion) under its "FCEV Vision 2030" and is part of the HyNet consortium to build 100 new hydrogen refueling stations in South Korea by 2022. If South Korea's vision is successful, it expects hydrogen to account for 5% of its projected power consumption in 2040, to see its economy grow by 43 trillion won, 420,000 new jobs created, and significant reductions in both fine dust and greenhouse gas emission.

COVID-19 has caused a serious impact on the global economy. Effectively stimulating consumption has become a momentous mission in responding to the impact of the epidemic. The popularity of mobile shopping makes shopping behavior no longer limited by time and space, so impulse purchase is more commonly seen nowadays; it can effectively promote residents' consumption. However, consensus has not been reached regarding how impulse purchase emerges as a phenomenon, thus making it difficult to promote consumers' purchase behavior. This article aims to explore the generation process of consumers' impulsive purchase intention during the COVID-19 outbreak from the perspective of system users. For this purpose, the research proposes three mobile situation factors personalized recommendation, visual appeal, and system usability. They have a positive impact on impulse purchase intention by influencing perceived arousal and perceived enjoyment. The experimental method is used for data collection and hypothesis testing. GSK621 nmr All the hypotheses are supported. And the theoretical value of the model of "mobile environment stimulation-consumer emotion-impulse purchase intention" is confirmed. Based on the conclusion, management suggestions are proposed for mobile shopping merchants from the perspective of improving consumers' shopping experience and expanding marketing.The therapeutic benefits of mesenchymal stromal cell (MSC) transplantation have been attributed to their secreted factors, including extracellular vesicles (EVs) and soluble factors. The potential of employing the MSC secretome as an alternative acellular approach to cell therapy is being investigated in various tissue injury indications, but EVs administered via bolus injections are rapidly sequestered and cleared. However, biomaterials offer delivery platforms to enhance EV retention rates and healing efficacy. In this review, we highlight the mechanisms underpinning the therapeutic effects of MSC-EVs and soluble factors as effectors of immunomodulation and tissue regeneration, conferred primarily via their nucleic acid and protein contents. We discuss how manipulating the cell culture microenvironment or genetic modification of MSCs can further augment the potency of their secretions. The most recent advances in the development of EV-functionalized biomaterials that mediate enhanced angiogenesis and cell survival, while attenuating inflammation and fibrosis, are presented. Finally, some technical challenges to be considered for the clinical translation of biomaterials carrying MSC-secreted bioactive cargo are discussed.The hedgehog signaling pathway plays a critical role in bone development and regeneration. Applications of hedgehog morphogens or small molecular agonists are of interest in bone repair but constrained by low stability, high dose requirement, and nonspecific targeting in vivo. Herein, a nanoparticulate agonist as a new type of hedgehog signaling activator is developed for efficacious bone healing. The shell of nanoparticulate agonist consists of palmitic acid and oxysterol, which could modify hedgehog function and bind with the smoothened receptor to positively modulate hedgehog signaling. Meanwhile, the core is assembled with sonic hedgehog gene/polyethyleneimine complex, which could synergistically enhance hedgehog signaling with oxysterol constituents. Moreover, alendronate is introduced into nanoparticulate agonist to bind with hydroxyapatite for potential bone tissue targeting. Lastly, the nanoparticulate agonist surface is decorated with the guanidine group to overcome cell membrane barriers. The created multifunctional nanoparticulate agonist is successfully integrated onto apatite-coated three-dimensional scaffolds and demonstrates greatly improved osteogenesis in vitro and calvarial bone healing.