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© 2020 Society for the Experimental Analysis of Behavior.Land subsidence caused by groundwater overexploitation is a serious global problem. The acquisition of spatiotemporal pumping rates and volumes is a first step for water managers to develop a strategic plan for mitigating land subsidence. This study investigates an empirical formulation to estimate the monthly maximum pumped volume over a 10-year period based on electric power consumption data. A spatiotemporal variability analysis of monthly pumped volume is developed to provide an improved understanding of seasonal pumping patterns and the role of irrigation type. The analysis of regional pumped volume provides an approximation of the spatiotemporal patterns of the variations in pumped volume. Results show the effects of climate, seasonal changes in pumping from irrigation, and the local differences in pumping caused to crop types. A seasonal pumped volume peak occurs annually, with the highest and least pumped volumes occurring in March (highest peak) and September (lowest peak), respectively. However, the majority of the historical maximum pumped volumes have occurred during the last few years. Extracted volumes continue to increase in some locations. The analysis reveals increasing trends in pumping, thereby possibly providing the locations where increased effective stresses may lead to land subsidence. This article is protected by copyright. All rights reserved.BACKGROUND This study examines the predictive value of a novel systemic immune-inflammation index (SII, platelet * neutrophil/lymphocyte ratio) in coronary artery disease (CAD) patients. METHODS 5602 CAD patients who had undergone a percutaneous coronary intervention (PCI) were enrolled. https://www.selleckchem.com/products/a1874.html Divided into two groups by baseline SII score (high SII vs. low SII) to analyze the relationship between SII groups and the long-term outcome. The primary outcomes were major cardiovascular events (MACE) which includes nonfatal myocardial infarction (MI), nonfatal stroke and cardiac death. Secondary outcomes included a composite of MACE and hospitalization for congestive heart failure. RESULTS An optimal SII cut-off point of 694.3×109 was identified for MACE in the CAD training cohort (n=373) and then verified in the second larger CAD cohort (n=5602). Univariate and multivariate analyses showed that a higher SII score (≥ 694.3) was independently associated with increased risk of developing cardiac death (HR 2.02; 95% CI 1.43-2.86), nonfatal MI (HR 1.42; 95% CI 1.09-1.85), nonfatal stroke (HR 1.96; 95% CI 1.28-2.99), MACE (HR 1.65; 95% CI 1.36-2.01), and total major events (HR 1.53; 95% CI 1.32-1.77). In addition, the SII significantly improved risk stratification of MI, cardiac death, heart failure, MACE and total major events than conventional risk factors in CAD patients by the significant increase in the C-index (p less then 0.001) and reclassification risk categories by significant NRI (p less then 0.05) and IDI (p less then 0.05). CONCLUSIONS SII had a better prediction of major cardiovascular events than traditional risk factors in CAD patients after coronary intervention. This article is protected by copyright. All rights reserved.OBJECTIVE The aim of this study was to determine the relationship between milk urea nitrogen (MUN) and reproductive performance in dairy cows in western Thailand. DESIGN All cows calving from November 2014 to April 2015 were included in the study, a total of 486 cows from 47 farms. Each cow had milk constituents and MUN tested monthly up to confirmed conception or until the 8th month after parturition. Each farm had a dietary assessment completed. Cox proportional hazard models with shared frailty were used to determine associations of conception rate. RESULTS Cows became pregnant increasingly quickly over time, except during 100-150 days of lactation. A change in MUN from 12.5 to 13.5 mg/dL on the closet day to breeding was associated with a 5% decrease in conception. Milk protein was negatively associated with hazard of conception, whereas milk lactose and dietary proteinenergy ratio had positive associations with conception rate. Breeding season was also significant; the highest conception rate was observed in cows inseminated during winter, whereas insemination during the humid rainy season resulted in the lowest conception rates. The farm random effect in the model was strongly significant. CONCLUSION Detrimental effects of higher MUN on rate of conception were identified. The rate of conception was positively associated with proteinenergy ratio in the study. Therefore, good nutritional management leading to positive energy balance should benefit conception rates. © 2020 Australian Veterinary Association.BACKGROUND Accurate estimation of fetal weight is essential in guiding management of fetuses with abdominal wall defects (AWDs), as growth restriction is an important predictor of perinatal morbidity and mortality. Several sonographic formulae are available involving multiple biometric parameters, but abdominal circumference measurements may underestimate weight in fetuses with AWDs. No formula has yet shown superior accuracy. AIMS The objectives of this study were to evaluate, in fetuses with gastroschisis and omphalocoele, the accuracy of a sonographic estimated fetal weight (EFW) formula proposed by Siemer and colleagues, specifically for use in fetuses with AWDs compared to the commonly used Hadlock IV formula in estimating fetal weight, and detecting small for gestational age (SGA) fetuses. MATERIALS AND METHODS A retrospective cohort of 113 fetuses with AWDs was identified from an Australian teaching hospital over 13 years. Pregnancy data and sonographic fetal biometry parameters were obtained. The accuracy of each formula in predicting birthweight was compared using Bland-Altman limits of agreement, and the intraclass correlation coefficient between EFW and actual birthweight. Performance of each formula in detecting SGA fetuses was determined. RESULTS The Siemer and Hadlock formulae have similar accuracies for predicting birthweight in fetuses with AWDs. The Hadlock formula has a higher detection rate for SGA  less then  10th centile and  less then  3rd centile compared to the Seimer formula (84% vs 68% and 83% vs 67% respectively), albeit with a higher false-positive rate. CONCLUSION There is no clear clinical advantage in using the Siemer formula, which is specifically designed for fetuses with AWDs, over the Hadlock formula to estimate weight in fetuses with AWDs. © 2020 The Royal Australian and New Zealand College of Obstetricians and Gynaecologists.

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