Alscowan8460

The label-feedback hypothesis (Lupyan, 2012) proposes that language modulates low- and high-level visual processing, such as priming visual object perception. Lupyan and Swingley (2012) found that repeating target names facilitates visual search, resulting in shorter response times (RTs) and higher accuracy. In the present investigation, we conceptually replicated and extended their study, using additional control conditions and recording eye movements during search. Our goal was to evaluate whether self-directed speech influences target locating (i.e. attentional guidance) or object perception (i.e., distractor rejection and target appreciation). In three experiments, during object search, people spoke target names, nonwords, irrelevant (absent) object names, or irrelevant (present) object names (all within-participants). Experiments 1 and 2 examined search RTs and accuracy Speaking target names improved performance, without differences among the remaining conditions. Experiment 3 incorporated eye-tracking Gaze fixation patterns suggested that language does not affect attentional guidance, but instead affects both distractor rejection and target appreciation. When search trials were conditionalized according to distractor fixations, language effects became more orderly Search was fastest while people spoke target names, followed in linear order by the nonword, distractor-absent, and distractor-present conditions. We suggest that language affects template maintenance during search, allowing fluent differentiation of targets and distractors. Materials, data, and analyses can be retrieved here https//osf.io/z9ex2/.Eye fixation patterns during mental imagery are similar to those during perception of the same picture, suggesting that oculomotor mechanisms play a role in mental imagery (i.e., the "looking at nothing" effect). Previous research has focused on the spatial similarities of eye movements during perception and mental imagery. The primary aim of this study was to assess whether the spatial similarity translates to the temporal domain. We used recurrence quantification analysis (RQA) to assess the temporal structure of eye fixations in visual perception and mental imagery and we compared the temporal as well as the spatial characteristics in mental imagery with perception by means of Bayesian hierarchical regression models. We further investigated how person and picture-specific characteristics contribute to eye movement behavior in mental imagery. Working memory capacity and mental imagery abilities were assessed to either predict gaze dynamics in visual imagery or to moderate a possible correspondence between spatial or temporal gaze dynamics in perception and mental imagery. We were able to show the spatial similarity of fixations between visual perception and imagery and we provide first evidence for its moderation by working memory capacity. Sunitinib Interestingly, the temporal gaze dynamics in mental imagery were unrelated to those in perception and their variance between participants was not explained by variance in visuo-spatial working memory capacity or vividness of mental images. The semantic content of the imagined pictures was the only meaningful predictor of temporal gaze dynamics. The spatial correspondence reflects shared spatial structure of mental images and perceived pictures, while the unique temporal gaze behavior could be driven by generation, maintenance and protection processes specific to visual imagery. The unique temporal gaze dynamics offer a window to new insights into the genuine process of mental imagery independent of its similarity to perception.The average predictability (aka informativity) of a word in context has been shown to condition word duration (Seyfarth, 2014). All else being equal, words that tend to occur in more predictable environments are shorter than words that tend to occur in less predictable environments. One account of the informativity effect on duration is that the acoustic details of probabilistic reduction are stored as part of a word's mental representation. Other research has argued that predictability effects are tied to prosodic structure in integral ways. With the aim of assessing a potential prosodic basis for informativity effects in speech production, this study extends past work in two directions; it investigated informativity effects in another large language, Mandarin Chinese, and broadened the study beyond word duration to additional acoustic dimensions, pitch and intensity, known to index prosodic prominence. The acoustic information of content words was extracted from a large telephone conversation speech corpus with over 400,000 tokens and 6000 word types spoken by 1655 individuals and analyzed for the effect of informativity using frequency statistics estimated from a 431 million word subtitle corpus. Results indicated that words with low informativity have shorter durations, replicating the effect found in English. In addition, informativity had significant effects on maximum pitch and intensity, two phonetic dimensions related to prosodic prominence. Extending this interpretation, these results suggest that predictability is closely linked to prosodic prominence, and that the lexical representation of a word includes phonetic details associated with its average prosodic prominence in discourse. In other words, the lexicon absorbs prosodic influences on speech production.We report the case of a MS patient on subcutaneous ofatumumab who became infected with SARS-CoV-2 and remained asymptomatic while developing antiviral IgM and IgG antibodies. The patient was B-cell depleted with normal serum immunoglobulin levels. Anti-SARS-CoV-2 IgG antibodies remained positive three months after the initial infection. These findings suggest that a MS patient treated with ofatumumab may be able to mount an effective humoral response to SARS-CoV-2 infection and probably to COVID-19 vaccines as well. Further research will be necessary to evaluate the humoral response of MS patients on ofatumumab to SARS-CoV-2 infection and COVID-19 vaccines.

Event-related potentials (ERPs) have been proposed as a neurophysiological biomarker to capture cognitive dysfunction in multiple sclerosis (MS). Few studies have evaluated the relationships between ERPs and brain atrophy as known marker of structural brain damage related to cognitive impairment (CI).

To explore the relationships of brain atrophy, including of the cortex and deep grey matter, with ERP abnormalities and cognitive function, as defined using the Brief Repeatable Battery of Neuropsychological Tests (BRBN).

Seventy-eight patients with relapsing-remitting MS were enroled, of which 38 (48.7%) had CI. Independent t-test comparisons of the ERP parameters found a significant difference in P300 wave latency, with a latency of 343.7±32.6ms in the CI group vs. 320.3±16.5ms in the cognitively preserved (CP) group (p=0.001). Significant differences in the MRI measurements, including the cortex (p=0.02) and deep grey matter structures [thalamus (p=0.001), amygdala (p=0.030), and nucleus accumbens (p=0.