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The increasing incidence of antimicrobial resistance represents a global threat. As a result, surveillance programmes monitoring antimicrobial consumption and resistance in animals have been implemented in several countries throughout the world. However, such programmes depend on the accurate and detailed collection of data on antimicrobial consumption. For this reason, the aim of this longitudinal study was to compare the consistency of data on antimicrobial consumption between three different data collection methods. this website Antimicrobial consumption data associated to udder health were collected from 20 veterinary practices and 92 dairy farms for 18 months. The compared data sources were 1) data extracted from veterinary practice software 2) farm treatment journals and 3) on-farm discarded drug packages (garbage). Two different procedures were chosen to analyse the data issued from treatment journals 1) only complete entries were analysed 2) entries with missing dosage were supplemented with the information providilst most systemic preparations were collected using software data. The results of the study show a lack of data consistency between the three different data sources. None of the methods was able to collect the integral antimicrobial consumption in the participating farms. Finally, the results emphasise the need to implement a standardised system to quantify and assess the antimicrobial consumption at veterinary practice and farm level.

This study examined sensory gating in children with autism spectrum disorders (ASD). Gating is usually examined at the P50 component and rarely at mid- and late-latency components.

Electroencephalography data were recorded during a paired-click paradigm, from 18 children with ASD (5-12years), and 18 typically-developing (TD) children. Gating was assessed at the P50, N1, P2, and N2 event-related potential components. Parents of all participants completed the Short Sensory Profile (SSP).

TD children showed gating at all components while children with ASD showed gating only at P2 and N2. Compared to TD children, the ASD group showed significantly reduced gating at P50, N1, and P2. No group differences were found at N2, suggesting typical N2 gating in the ASD group. Time-frequency analyses showed reduced orientation and neural synchronization of auditory stimuli. P50 and N1 gating significantly correlated with the SSP.

Although children with ASD have impaired early orientation and filtering of auditory stimuli, they exhibited gating at P2 and N2 components suggesting use of different gating mechanisms compared to TD children. Sensory deficits in ASD may relate to gating.

The data provide novel evidence for impaired neural orientation, filtering, and synchronization in children with ASD.

The data provide novel evidence for impaired neural orientation, filtering, and synchronization in children with ASD.

Hyperbilirubinemia is frequent in patients with hematological malignancies admitted to the intensive care unit (ICU). Literature about hepatic dysfunction (HD) in this context is scarce.

We investigated the prognostic impact of HD analyzing a prospective multicenter cohort of 893 critically ill hematology patients. Two groups were defined patients with HD (total bilirubin ≥33μmol/L at ICU admission) and patients without HD.

Twenty one percent of patients were found to have HD at ICU admission. Cyclosporine, antimicrobials before ICU admission, abdominal symptoms, ascites, history of liver disease, neutropenia, increased serum creatinine and myeloma were independently associated with HD. Etiology remained undetermined in 73% of patients. Hospital mortality was 56.3% and 36.3% respectively in patients with and without HD (p<0.0001). Prognostic factors independently associated with hospital mortality in HD group were, performance status >1 (OR=2.07, 95% CI=1.49-2.87, p<0.0001), invasive mechanical ventilation (OR=3.92, 95% CI=2.69-5.71, p<0.0001), renal replacement therapy (OR=1.74, 95% CI=1.22-2.47, p=0.002), vasoactive drug (OR=1.81, 95% CI=1.21-2.71, p=0.004) and SOFA score without bilirubin level at ICU admission (OR=1.09, 95% CI=1.04-1.14, p<0.0001).

HD is common, underestimated, infrequently investigated, and is associated with impaired outcome in critically ill hematology patients. HD should be considered upon ICU admission and managed as other organ dysfunctions.

HD is common, underestimated, infrequently investigated, and is associated with impaired outcome in critically ill hematology patients. HD should be considered upon ICU admission and managed as other organ dysfunctions.Pulmonary sequestration consists of a nonfunctioning mass of lung tissue, either sharing the pleural envelope of the normal lung (intralobar) or with its own pleura (extralobar), lacking normal communication with the tracheobronchial tree and receiving its arterial supply by one or more systemic vessels. It is the second most common congenital lung anomaly according to pediatric case series, but its real prevalence is likely to be underestimated, and imaging plays a key role in the diagnosis and treatment management of the condition and its potential complications. We will give a brief overview of the pathophysiology, clinical presentation and imaging findings of intra- and extralobar pulmonary sequestration, with particular reference to multidetector computed tomography as part of a powerful and streamlined diagnostic approach.

To examine patellofemoral joint (PFJ) loading in two lunge movements Forward Lunge (FL) and Backward Lunge (BL).

Repeated Measures.

University Biomechanics Laboratory.

20 asymptomatic females.

Six trials of two lunge movements (FL and BL) to a depth of 75% of leg length were performed. 3-D motion capture and force platforms were used to collect data as input into a musculoskeletal model to determine quadriceps force, PFJ reaction force, PFJ stress, and knee flexion angle.

Multivariate analysis indicated differences in PFJ loading variables and joint angles between the lunge movements (Forward vs. Backward) and phases (Down vs. Up). Quadriceps force, PFJ reaction force, and knee flexion angle were larger in the FL movement and Up phases. PFJ loading rate was greater in the FL movement along with a lower forward trunk tilt.

The FL produced greater PFJ loading variables compared to the BL. Further research is needed to examine a population of individuals who have patellofemoral pain (PFP) to see if their symptoms may be reduced when using the BL.