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Adenoid cystic is a rare histological subtype of basal cell carcinoma. Basal cell carcinoma (BCC), the most common form of skin cancer is a slow-spreading tumor with local malignancy, with a high cure rate and favorable prognosis when is diagnosed in the early stages. Rhinophyma is one of the four subtypes of rosacea and it is histopathologically characterized by sebaceous glands hypertrophy. Disseminated annular granuloma (GAD) is a rare inflammatory dermatosis with uncertain etiopathogenesis, clinically represented by papules with annular or arciform aspect. UV radiations aggravates rosacea and are involved in the etiopathogenesis of BCC and can have a triggering or an aggravating effect on GAD. The association of adenoid cystic BCC with rhinophyma it is rare and more than that, the presence of both in association with GAD is not described in medical literature. selleck chemicals llc We present the case of a 78-year old male patient, with personal history of prolonged exposure to UV radiations, that was admitted to the Dermatology for 4 nodular tumors, located on the face. The skin of the nose and menton with thickened, hypertrophied, irregular, red appearance and dilated pores. Also, on the upper limbs and trunk, the patient had, erythematous papules with arciform and ring shape with hypopigmented centers. We performed surgical excision of the tumors and biopsied an annular lesion. Microscopic examination showed nodular basal cell carcinoma with areas of adenoid cystic carcinoma and actinic degeneration of collagen and gigantocellular granulomatous inflammation. The skin biopsied from the upper limb showed annular granuloma appearance.Numerous plants are traditionally grown in kitchen gardens and consumed by the general population. Incidents of accidental ingestion of harmful plants due to their striking resemblance with the edible ones are well-known. Cases A family of three (a mother and her two children) unintentionally consumed leaves of small plants of Datura stramonium, instead of Solanum nigrum. They were admitted in intensive care unit with anticholinergic symptoms, treated symptomatically and discharged. On probing further, it is understood that both the plants look similar when young. However, it is easy to distinguish between them when the plants are fully grown. Conclusion It is essential to educate the public regarding proper identification of locally available leafy vegetables that are fit for consumption. Also, clinicians should have a high index of suspicion in such cases of family poisoning even in the absence of a reliable history.Currently, data that supports the clinical benefit of agents targeting the epidermal growth factor receptor (EGFR) in the therapy of squamous cell carcinoma (SCC) histologic version of the lung cancer (LC) is insufficient. In the following report we present the case of a patient treated with erlotinib for SCC NSCLC. At the time of initiation, there were no available guidelines recommendations regarding the EGFR status in for initiation of EGFR tyrosine kinase inhibitors (TKIs) therapy for NSCLC, thus the sample was never tested for the EGFR mutational status. Not widely used in the treatment of SCC, EGFR-TKIs remain a valid therapeutic option in selected groups of patients.The nasal turbinates adhere to the lateral nasal wall and are subjected to various morphological variations. A common variation is concha bullosa, the pneumatization of a nasal turbinate. Another possible variation is the secondary middle turbinate (SMT) which originates from the lateral wall of the middle nasal meatus. Pneumatized SMTs were previously found only twice in Computed Tomography (CT) studies. It is hereby reported the third such evidence, gathered in a 44 y.o. male patient which was scanned in Cone Beam CT (CBCT) for routine dental medical procedures. In the present case the superior turbinates were pneumatized and were found bilateral SMTs. The left SMT was unpneumatized and projected medially and the right SMT was pneumatized and projected infero-medially. The right pneumatized SMT was communicating through a narrow isthmus with the ethmoidal bulla; beneath these two, a large ethmoidal infundibulum opened medially through a narrow semilunar hiatus. Such extremely rare anatomic variations could impede on the normal drainage of the ostiomeatal unit and could lead to inadvertent surgical corridors if they are not documented in CT or CBCT.Worldwide, one of the leading causes of death for patients with cardiovascular disease is aortic valve failure or insufficiency as a result of calcification and cardiovascular disease. The surgical treatment consists of repair or total replacement of the aortic valve. Artificial aortic valve implantation via a percutaneous or endovascular procedure is the minimally invasive alternative to open chest surgery, and the only option for high-risk or older patients. Due to the complex anatomical location between the left ventricle and the aorta, there are still engineering design optimization challenges which influence the long-term durability of the valve. In this study we developed a computer model and performed a numerical analysis of an original self-expanding stent for transcatheter aortic valve in order to optimize its design and materials. The study demonstrates the current valve design could be a good alternative to the existing commercially available valve devices.Acute coronary events (ACE) are one of the main concerns for both clinical medicine and prophylaxis. The study aims to follow the frequency of the pathology associated with ACE and to establish its association with the occurrence of ACE. The study included 865 adult participants between the ages of 19-86. Subjects completed a complex questionnaire that included questions about health status. The study was conducted by applying the subjects to an anonymous questionnaire, in three family medicine practices between November 2018 to May 2019 and targeted healthy people. The frequencies of the following types of associated pathologies were evaluated high blood pressure (HBP), hypercholesterolemia, stroke, diabetes, depression, stress. In hypertensive patients the prevalence of ACE was 6,99% (N=11) and in those not diagnosed with HBP of only 0,29% (N=2). The risk of ACE was 20 times higher than in those without HBP (RR=20,93; p less then 0.001). The prevalence of ACE was high among subjects with high cholesterol levels (21,43%) compared with those with normal values (3,03%; N=22), the risk of ACE being 7 times higher (RR=7,06; p less then 0.

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