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nical diagnostic criteria in defining boundaries between distinct conditions and the difficulties of clinicians in reaching the best clinical diagnosis.

 G; p.Asn409Ser) determining reduced GCase activity. This report also confirms the role of NGS-based targeted gene analysis in detecting peculiar clinical phenotypes associated with known pathogenic mutations and reinforces the knowledge that carriers of genetic variants often present phenotypic overlaps across different neurodegenerative syndromes, highlighting the limitations of current clinical diagnostic criteria in defining boundaries between distinct conditions and the difficulties of clinicians in reaching the best clinical diagnosis.

To investigate the dentists' opinions towards social media (SM) use in daily practice and the expected limitations from its use in Saudi Arabia.

An electronic survey was carried out throughout May-June 2020 among a sample of dentists in Saudi Arabia. The survey covered three parts the first part covered professional and demographic information, the second part covered the use of mobile phones and SM in dental practice, while the third part assessed dentists' opinion on SM use. click here Descriptive statistics included frequency distributions and percentages and independent t test/ANOVA test for the relationship between the mean of dentists' opinion towards SM and demographic variables. A p value of 0.05 or less was considered statistically significant.

The majority of respondents (80%) believe that SM plays an active role in patients' decisions regarding the selection of a healthcare provider. The mean dentists' opinion scores on the use of SM were significantly lower among participants working more than 50h per week compared with other participants (p = 0.014).

The majority of sampled dentists believe that SM plays an active role in patients' decisions regarding the healthcare provider's selection. Directed campaigns can help dentists optimize the use of SM for both professional and personal purposes.

The majority of sampled dentists believe that SM plays an active role in patients' decisions regarding the healthcare provider's selection. Directed campaigns can help dentists optimize the use of SM for both professional and personal purposes.

Dorsolateral medullary infarction is a typical cerebral infarction which is characterized by Wallenberg's syndrome. Neurotrophic keratopathy is an uncommon consequence of dorsolateral medullary infarction. At present, the protocol is aimed to study the dynamic changes in corneal innervation and the ocular surface environment after dorsolateral medullary infarction.

This study will involve consecutive data from all medical records of patients within 7days of acute dorsolateral medullary infarction onset at the Departments of Neurology from 10 collaborating stroke centers. Eligible patients will mainly be characterized based on detailed physical examinations, multimodal imaging, and corneal related examinations and patients will be followed-up for 2years. Neurotrophic keratopathy after dorsolateral medullary infarction is the primary endpoint. The dynamic histological corneal innervation and ocular surface environment after dorsolateral medullary infarction will be observed during the follow-up period.

This multicentric, prospective registry is the first to identify and characterize the dynamic changes of corneal innervation and the ocular surface environment after acute dorsolateral medullary infarction. The significance of the study is to emphasize that the curative effect is based on the doctors' identification of the disease in the earliest stage before irreversible damage occurs to the cornea.

The registry was registered ( ChiCTR-OPC-17,011,625 ) on June 11, 2017.

The registry was registered ( ChiCTR-OPC-17,011,625 ) on June 11, 2017.

Surgery is the only treatment option for operable gastric cancer. The CLASSIC and ACTS-GC studies showed that the 5-year overall survival (OS) of patients with stage III gastric cancer undergoing D2 gastrectomy is still very low. Whether adjuvant nanoparticle albumin-bound paclitaxel (nab-paclitaxel) combined chemotherapy is more effective than the XELOX standard adjuvant chemotherapy in patients with stage III gastric cancer has not been confirmed.

This is a multicenter, open-label, phase III clinical study. In this trial, 616 patients with locally advanced stage III gastric cancer that underwent curative D2 radical surgery and achieved R0 are planned to be included. Patients will be randomized 11 to nab-paclitaxel combined with S-1 (AS) vs. oxaliplatin combined with capecitabine (XELOX). XELOX group Patients assigned to the XELOX group received eight 3-week cycles of oral capecitabine (1000 mg/m

) twice daily on days 1-14 of each cycle plus intravenous oxaliplatin 130 mg/m

on day 1 of each cycle. AS his clinical trial has been registered with ClinicalTrials.gov, registration number NCT04135781 , on October 20th, 2019.

This clinical trial has been registered with ClinicalTrials.gov, registration number NCT04135781 , on October 20th, 2019.

Macular edema secondary to retinal vein occlusion (RVO) is an important cause of loss of vision. Intravitreal injections (IVI) of anti-vascular endothelial growth factor (VEGF) are the standard of care in this disease, as shown in numerous randomized controlled trials. The purpose of this study was to study the efficacy and safety of ranibizumab, an anti-VEGF agent, in the real-world setting.

This was 48 weeks, open-label, prospective, multicentre, observational study. Patients diagnosed with ME secondary to RVO were treated with IVI of Ranibizumab 0.5 mg in real-world conditions. Efficacy was measured by improvement seen in best-corrected visual acuity (BCVA) in terms of Early Treatment of Diabetic Retinopathy Study (ETDRS) Letter Scores and change in central retinal thickness (CRT) measured by optical coherence tomography.

One hundred eyes of 100 patients (79 with branch retinal vein occlusion and 21 with central retinal vein occlusion) were recruited in the study. The mean (standard deviation, SD) BCVA was 52.8 (21.99) letters at baseline and 62.3 (24.40) letters at week 48. From baseline, there was a significant improvement in BCVA by 7.7 letters (p = 0.001) at 48 weeks. The mean (SD) of CRT was 479.9 (216.25) μm at baseline and it decreased significantly to 284.9 (171.35) μm at week 48 (p < 0.001). During the study period, the average number of intravitreal injections was 3.5 per patient. There was no report of endophthalmitis in any eye.

Ranibizumab is well tolerated and effective in treating macular edema secondary to RVO in real-world clinical settings. However, there is under-treatment compared to controlled clinical trials, and the gain in vision is sub-optimal with under-treatment.

Clinical Trials Registry - India CTRI/2015/07/005985 .

Clinical Trials Registry - India CTRI/2015/07/005985 .