Aggerholmduffy3246

Logistic regression was performed to evaluate for potential risk factors for subclinical bacteriuria. RESULTS Hyperthyroid cats showed a low prevalence of subclinical bacteriuria (4.3%), which did not differ from that found in euthyroid cats (4.6%). Of the signalment factors evaluated, only female sex was a significant risk factor (odds ratio [OR], 6.9; P = .002). Furthermore, positive urine cultures were more likely in specimens with dilute urine concentration ( less then 1.035), pyuria, or microscopic bacteriuria. CONCLUSIONS AND CLINICAL IMPORTANCE Hyperthyroid cats are not at risk for subclinical bacteriuria. In the absence of lower urinary tract signs, no clinical benefit exists in routinely performing urine cultures when evaluating hyperthyroid cats. © 2020 The Authors. Journal of Veterinary Internal Medicine published by Wiley Periodicals, Inc. on behalf of the American College of Veterinary Internal Medicine.OBJECTIVE Observational studies point to an inverse correlation between LDL cholesterol levels and risk of intracerebral hemorrhage (ICH), but it remains unclear whether this association is causal. We tested the hypothesis that genetically-elevated LDL is associated with reduced risk of ICH. METHODS We constructed one polygenic risk score (PRS) per lipid trait (total cholesterol, LDL, HDL and triglycerides) using independent genome-wide significant SNPs for each trait. We used data from 316,428 individuals enrolled in the UK Biobank to estimate the effect of each PRS on its corresponding trait, and data from 1,286 ICH cases and 1,261 matched controls to estimate the effect of each PRS on ICH risk. We used these estimates to conduct Mendelian Randomization analyses. RESULTS We identified 410, 339, 393, and 317 lipid-related SNPs for total cholesterol, LDL, HDL and triglycerides, respectively. All four PRSs were strongly associated with their corresponding trait (all p0.05). Mendelian Randomization analyses indicated that 1 mmol/L (38.67 mg/dL) increase of genetically-instrumented total and LDL cholesterol were associated with 23% (OR 0.77; 95%CI 0.65-0.98; p=0.03) and 41% lower risks of ICH (OR 0.59; 95%CI 0.42-0.82; p=0.002), respectively. INTERPRETATION Genetically elevated LDL levels were associated with lower risk of ICH, providing support for a potential causal role of LDL cholesterol in ICH. This article is protected by copyright. All rights reserved. This article is protected by copyright. All rights reserved.Towards the end of 2020, Parties to the Convention on Biological Diversity (CBD) are expected to meet in Kunming, China, to agree a new global biodiversity framework aimed at halting and reversing biodiversity loss, encouraging the sustainable use of biodiversity, and ensuring the equitable sharing of its benefits. As the new post-2020 global biodiversity framework evolves, Parties to the Convention are being exposed to a range of perspectives on the conservation and sustainable use of biodiversity, relating to the future framework as a whole or to aspects of it. Area-based conservation measures are one such aspect, and there are diverse 'perspectives' on how new targets might be framed in relation to these measures. These perspectives represent different outlooks on the relationship between human and non-human life on earth. However, in most cases there is a lack of clarity on how they would be implemented in practice, the implications this would have for biodiversity and human-wellbeing, and how they would contribute to achieving the 2050 Vision for Biodiversity of "living in harmony with nature". We seek to clarify these issues by summarising some of these perspectives in relation to the future of area-based biodiversity conservation. We show that although the perspectives are in some cases at odds with one another, they also share commonalities, and all have elements that can contribute to developing and implementing the post-2020 global biodiversity framework and achieving the longer term 2050 Vision. Article impact statement Scaling up area-based conservation is essential to post-2020 framework to address the CBD mission to improve the status of biodiversity. This article is protected by copyright. All rights reserved. This article is protected by copyright. All rights reserved.OBJECTIVE The purpose of this study was to establish prognostic factors in fetuses diagnosed with periventricular pseudocysts (PVPCs) without known congenital infection, between 28-37 weeks of gestation. METHODS This retrospective study included cases of fetal PVPC from 2008 to 2018. PVPCs were classified according to location, number, extension, morphology and size. Additional findings, MRI and genetic studies were recorded. Pregnancy outcome, postnatal or postmortem results were obtained. Images from patients with normal (Group1) and abnormal postnatal development (Group 2) were compared for analysis of factors predictive of outcome. RESULTS One-hundred-and-fifteen pseudocysts were observed in 59 patients. In 34 fetuses (57%) the PVPC was an isolated finding. AZD3229 Thirty-nine patients delivered live newborns, 27% opted for termination of pregnancy and 4 patients were lost to follow-up. Eighty-four percent of the liveborns had normal development. When assessing for the influence of pseudocyst characteristics, a wide CSP, or large head circumference, neither of these affected the outcome. The presence of additional anomalies was the only positive predictor for abnormal development regradless of specific PVPC characteristics (P = 0,002). CONCLUSIONS In fetuses with PVPCs the presence of additional anomalies was the only predictor for adverse postnatal outcome. No association between cystic characteristics and adverse outcome was observed. This article is protected by copyright. All rights reserved. This article is protected by copyright. All rights reserved.Anthropogenic noise is a globally widespread sensory pollutant, recognised as having potentially adverse effects on function, demography, and physiology in wild animals. Human population growth, and associated changes in urbanisation, transportation, and resource extraction, all contribute to anthropogenic noise and are predicted to increase in the coming decades. As a result, wildlife exposure to anthropogenic noise is expected to rise correspondingly. Data collected by field research are uniquely important in advancing understanding of the real-world repercussions of human activity on wildlife. We therefore performed a comprehensive systematic review of literature published between 2008-2018 that reported field investigations of anthropogenic noise impacts. We evaluated publication metrics, geographical distribution, study subject, and methodology. Research activity increased markedly over the assessment period. However, there was a pronounced geographical bias in research, with most being conducted in North America or Europe, and a notable focus on terrestrial environments.