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agents are safe and effective to ensure sedation prior to painful burn-care procedures.

Results of this study indicate that dexmedetomidine causes hemodynamic alterations while midazolam causes respiratory depression. However, these effects are not severe, and we conclude that both agents are safe and effective to ensure sedation prior to painful burn-care procedures.

Nursing is an embodiment of knowledge, clinical work, and interpersonal communication. Effective nursing care has a distinct influence on the overall satisfaction and experience of the patient. Communication is said to be indispensable in the delivery of quality healthcare. Effective communication between nurses and patients has proven to yield better results with pain control and improved psychological status of patients.

The aim of the study is to explore nurses' perceptions on the role of communication in the management of burns pain.

A qualitative design with purposive sampling was carried out to recruit 11 registered nurses from a Reconstructive Plastic Surgery and Burns Center in Ghana. To identify the participants' perception on the role of nurse-patient communication in the management of burns pain, a face to face semi-structured interviews were conducted using an interview guide to collect data.

Thematic analysis was done with various themes emerging. Helping patients manage pain, early detecion.The first half of the year 2020 has been shaped by quarantines and lock-downs all over the world. The novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has caused a pandemic, that slowed down not only social interactions and economy, but also medical and health care. Governments and hospitals were forced to create ad hoc emergency plans maintaining the balance between an adequate participation in collective response of shutting-down to avoid a further spreading of the virus, while preserving the ongoing acute care and simultaneously being able to react to an imminent overextension with a collapse of capacities. The University Hospital Graz is one of the largest hospitals in Austria. As transregional trauma and burn centre it provides care for people from all over Austria and faced special challenges. We present the strategy of the University Hospital Graz in dealing with the COVID-19 pandemic and the way back to (new) normality. The strategy includes infrastructural, patient-centred and staff-centred measures. The continuously low numbers of new infections in Austria allowed a loosening of the lock-down measures already. Particular attention has to be paid to attentive screening of patients and triaging of surgeries during the re-boot. The re-boot needs to be slow and steady to reduce the risk of an infectiological relapse. Once this pandemic is defeated, a careful re-evaluation of the different internationally applied strategies should be performed to be prepared for the future.

Determination of the depth of burn wounds is still a challenge in clinical practise and fundamental for an optimal treatment. Hyperspectral imaging (HSI) has a high potential to be established as a new contact-free measuring method in medicine. From hyperspectral spectra 3D-perfusion parameters can be estimated and the microcirculatory of burn wounds over the first 72h after thermal injury can be objectively described.

We used a hyperspectral imaging camera and extended data processing methods to calculate 3D-perfusion parameters of burn wounds from adult patients. The data processing results in the estimation of perfusion parameters like volume fraction and oxygenation of haemoglobin for 6 different layers of the injured skin. The parameters are presented as depth profiles. We analyzed and compared measurements of wounds of different degrees of damage and present the methodology and preliminary results.

The depth profiles of the perfusion parameters show characteristic features and differences depending on the degree of damage. With Hyperspectral Imaging and the advanced data processing the perfusion characteristics of burn wounds can be visualized in more detail. Based on the analysis of this perfusion characteristics, a new and better reliable classification of burn degrees can be developed supporting the surgeon in the early selection of the optimal treatment.

The depth profiles of the perfusion parameters show characteristic features and differences depending on the degree of damage. With Hyperspectral Imaging and the advanced data processing the perfusion characteristics of burn wounds can be visualized in more detail. Based on the analysis of this perfusion characteristics, a new and better reliable classification of burn degrees can be developed supporting the surgeon in the early selection of the optimal treatment.

To investigate the possibility of an association between parental consanguinity and the occurrence of congenital ocular abnormalities.

A retrospective cross-sectional study was carried out over 3 years, from January 2016 to December 2018, in the pediatric ophthalmology unit of the University Hospital Campus of Lomé (Togo). It included children with congenital ocular abnormalities. Age, gender, geographic origin (city or urban area, village or rural area), degree of consanguinity of parents and types of congenital ocular abnomalities were the variables of study. Odds Ratio (OR) and logistic regression were used to investigate the correlation between parental consanguinity and the occurrence of congenital ocular abnormalities. A P-value of<0.05 was considered statistically significant.

Among the 103 patients with congenital ocular abnormalities, there were 60 (58.2%) males and 43 (41.8%) females. The mean age of the patients was 16 months, range 1 month-5 years. Patients born to consanguineous parents were 26.2% (27) of the total population. Of these 27 patients, 25 (92.6%) were born to second-cousin marriages and 24 (88.89%) came from a rural area. Parental consanguinity was correlated with developmental abnormalities of the globe (OR=37.50; 95% CI

[4.46-314.80]; r=3.62; P=0.00), sclerocornea (OR=13.04; 95% CI [1.39-122.54]; r=2.57; P=0.02) and corneal dystrophy (OR=9.37; 95% CI [0.93-94.36]; r=2.24; P=0.02).

Our study suggests the existence of a correlation between parental consanguinity and the occurrence of congenital ocular abnormalities.

Our study suggests the existence of a correlation between parental consanguinity and the occurrence of congenital ocular abnormalities.US emergency departments are facing a number of operational challenges related to chronic shortages of registered nurses. Many of the tasks done by registered nurses can be safely and successfully delegated to the emergency department technician (EDT), particularly if a hospital's nursing and administrative leadership are affirmatively engaged in a process to professionalize and train their EDT workforce. This paper examines the state, Joint Commission on Accreditation of Healthcare Organizations, and Centers for Medicare & Medicaid Services regulatory landscape for the EDT, reviews the literature on how hospital's utilize EDT's, discusses approaches to skills training, and examines the need for profession standardization that enables job role expansion.

Among patients with a known peanut allergy, previous studies suggest low carrying rates of epinephrine auto-injectors (EAIs) and hesitancy to self-administer epinephrine upon anaphylaxis onset. Given the high prescription rates of epinephrine and prevalence of peanut allergies, it is important to identify rates of on-scene EAI use and affecting factors.

The electronic medical records of 217 patients-either with an ED diagnosis of peanut anaphylaxis or diagnosis of anaphylaxis with a known epinephrine prescription from 2010 through May 2020--were reviewed for physician notes and demographic factors.

Epinephrine was administered on-scene by 25.3% of anaphylaxis patients. Of the 6 health care professionals identified, 100% administered epinephrine on-scene. Females (32.2%) were administered epinephrine on-scene more frequently than males (19.8%; p=0.04). Rate of epinephrine administration increased from 2010 through 2019 (p=0.005).

This study selected for individuals diagnosed with anaphylaxis, meaning Edicates that comfort with EAIs facilitates willingness to administer on-scene. EAIs can range up to $900 in expense, thus physicians should employ EAI training devices and other training strategies.CoFe2O4 (Cobalt ferrite, CF) nanoparticles were prepared, well characterized and applied as efficient solid catalyst in catalytic ozonation, named CF/O3 process, for the removal of emerging organic contaminants (EOCs). The degradation and mineralization of clofibric acid (CA) in CF/O3 process were dramatically enhanced in comparison with those under the O3 system. Surface hydroxyl groups (HGs) were considered as an important factor for ozone decomposition and the reactive oxygen species (ROS) on the catalyst surface were mainly responsible for CA elimination. The contribution and formation of ROS, including hydroxyl radicals (•OH), especially superoxide radicals (O2•-), singlet oxygen (1O2), and hydrogen peroxide (H2O2) were evaluated, and a rational mechanism was elucidated accordingly. Probable degradation pathway of CA was proposed according to the organic intermediates identified. The acute toxicity of the treated solution increased during the first 15 min and then declined rapidly and nearly disappeared as the reaction proceeded. In addition, acceptable catalytic performance of CF/O3 can be obtained for the treatment of other EOCs and the treatment of natural surface water spiked with CA. This work presents an efficient and promising catalytic ozonation technique for the elimination of EOCs in complex water matrices.The coexistence of nanoplastics (NPs) and various pollutants in the environment has become a problem that cannot be ignored. In order to identify the microcystin-LR (MCLR) bioaccumulation and the potential impacts on the early growth of F1 zebrafish (Danio rerio) offspring in the presence of polystyrene nanoplastics (PSNPs), PSNPs and MCLR were used to expose adult zebrafish for 21days. The exposure groups divided into MCLR (0, 0.9, 4.5 and 22.5μgL-1) alone groups and PSNP (100μgL-1) and MCLR co-exposure groups. R-848 clinical trial F1 embryos were collected and developed to 120 h post-fertilization (hpf) in clear water. Compared with the exposure to MCLR only, the combined exposure increased the parental transfer of MCLR to the offspring and subsequently exacerbated the growth inhibition of F1 larvae. Further research clarified that combined exposure of PSNPs and MCLR could reduce the levels of thyroxine (T4) and 3, 5, 3'-triiodothyronine (T3) by altering the expression of hypothalamus-pituitary-thyroid (HPT) axis-related genes, eventually leading to growth inhibition of F1 larvae. Our results also exhibited combined exposure of PSNPs and MCLR could change the transcription of key genes of the GH/IGF axis compared with MCLR single exposure, suggesting the GH/IGF axis was a potential target for the growth inhibition of F1 larvae in PSNPs and MCLR co-exposure groups. The present study highlights the potential risks of coexistence of MCLR and PSNPs on development of fish offspring, and the environmental risks to aquatic ecosystems.