Abildgaardhodges0581

We sought to examine the natural history of geriatric assessment (GA) and quality of life (QOL) domains among adults age≥50years undergoing autologous hematopoietic cell transplantation (autoHCT).

A QOL tool and cancer-specific GA were completed before autoHCT in patients ≥50years, and at 100days, six months, and one year post-transplant.

One hundred eighty-four patients completed the pre-transplant QOL/GA assessment, 169 (92%) completed the 100-day assessment, 162 (88%) completed the six-month assessment, and 145 (79%) completed the twelve-month assessment. Functional status, as measured by instrumental activities of daily living (IADL), decreased from baseline to day 101 (mean change -0.42 points, 95% CI, -0.75 to -0.09, p=0.01) but returned to baseline by one year. Physical function as measured by Medical Outcomes Study-Physical Health (MOS-PH) increased by mean of 3.27 points (95% CI, -0.02 to 6.56, p=0.05) by one year. Physician-rated KPS improved by one year, but patient-rated KPS did not. No QOL metric deteriorated from baseline. Baseline factors predictive of IADL and MOS-PH as measured over time included comorbidities and disease status at transplant. IADL and MOS-PH as measured over time were not significantly associated with age.

AutoHCT for adults age≥50years resulted in an initial decrease in functional status, with subsequent improvement back to baseline by one year. Physical health and QOL measures were improved or unchanged over time. AutoHCT is well tolerated in well selected older patients, using patient reported geriatric metrics as outcomes.

AutoHCT for adults age ≥ 50 years resulted in an initial decrease in functional status, with subsequent improvement back to baseline by one year. selleck chemicals Physical health and QOL measures were improved or unchanged over time. AutoHCT is well tolerated in well selected older patients, using patient reported geriatric metrics as outcomes.

Older people with lung cancer are often frail and unfit due to their cancer and co-morbidities and may tolerate cancer treatments poorly. Physical activity (PA) and a healthy diet offer quality of life benefit to people with cancer before, during, and post treatment. However, older adults are poorly represented in the clinical trials on which recommendations were made.

To assess the acceptability, usefulness, and practicality of delivering a tailored wellbeing (PA and nutrition) intervention for older adults with lung cancer before, during, and after cancer treatments (chemotherapy and/or immunotherapy).

Semi-structured interviews conducted with nine patients with lung cancer and three patients with mesothelioma, ≥70years and ten informal carers, and nine Multidisciplinary Team (MDT) members. A topic guide covered the acceptability, usefulness, and practicality of a wellbeing intervention as well as specific feedback on individual components. Data were subjected to thematic analysis.

Four themes were to individual need and address physical limitations, psychological and social welfare in addition to PA and nutritional advice.

Iodine-125 (

I) is the most commonly used isotope for prostate brachytherapy (BT). Cesium-131 (

Cs) has a higher dose rate and shorter dose delivery time resulting in decreased duration of acute urinary morbidity. Long-term data suggest excellent oncologic outcomes; it is not known how outcomes compare. A prospective randomized trial comparing the two isotopes was initiated.

Patients with low- or intermediate-risk disease were treated with a BT in a single outpatient facility. Prescription dose was 144Gy for

I and 115Gy for

Cs. Androgen deprivation or supplemental EBRT was not allowed. The primary study objective was comparison of the mean EPIC Urinary Domain Score. Secondary objective was biochemical relapse-free survival (BRFS) comparison. Time-to-event for all outcomes of interest was measured from implant date.

One hundred forty men were enrolled; 81.4% were low-risk and 18.6% were intermediate-risk. The median followup was 97months. Urinary and sexual health-related quality of life did not differ between isotopes at any recorded time point. At 2months after implantation, bowel health-related quality of life was worse with

I; however, this difference was lost at subsequent time points. The 9-year BRFS was 87.2% and 84.0% for the

I and

Cs group, respectively (p= 0.897). There was no statistically significant difference in BRFS based on initial T stage, PSA, or Gleason score.

Short- and long-term urinary, sexual, and bowel quality of life, as well as long-term biochemical control were comparable between

I and

Cs. This report therefore supports the continued use of

Cs as an effective and comparable alternative isotope.

Short- and long-term urinary, sexual, and bowel quality of life, as well as long-term biochemical control were comparable between 125I and 131Cs. This report therefore supports the continued use of 131Cs as an effective and comparable alternative isotope.

Host genetic polymorphisms influence the fibrosis progression of chronic hepatitis C (CHC) patients. Previous studies have shown the association of human platelet antigens (HPAs) polymorphisms with CHC. However, little is known regarding the association of HPAs polymorphisms with the fibrosis progression of CHC. The aim of this study was to determine the association of HPA -2, -3, -5 and -15 polymorphisms with the levels of serum fibrosis marks in CHC patients.

The HPA -2, -3, -5 and -15 were genotyped by 5'-nuclease assay in 211 CHC patients, while the serum concentration of hyaluronic acid (HA), collagen IV (CIV), amino-terminal pro-peptide of type III procollagen (PIIINP), and laminin (LN) from the same samples were measured by time resolved fluorescence immunoassay.

The level of serum LN was significantly lower in CHC patients with HPA-15aa genotype compared to those with HPA-15ab/bb (P = 0.032) but did not differ among HPA-2, -3 and -5 genotypes. There were no difference in HA, CIV and PIIINP levels among HPA-2, -3,-5 and -15 genotypes.

This study demonstrates that HPA-15 aa polymorphism is associated lower serum LN in CHC, which suggests that HPA -15 aa may be involved in the fibrosis progression of CHC.

This study demonstrates that HPA-15 aa polymorphism is associated lower serum LN in CHC, which suggests that HPA -15 aa may be involved in the fibrosis progression of CHC.Intralesional sclerotherapy for lymphatic malformations (LMs) has become a modality of choice because of the high morbidity and recurrence rates with surgical excision. Traditionally, the macrocystic variant has shown good results with sclerotherapy. This prospective study was performed to evaluate the role of bleomycin sclerotherapy in the management of different radiological variants of LM. A total of 142 patients were included in this study. The lesions were classified as macrocystic, microcystic, or mixed LMs on the basis of ultrasonography. All patients were managed by intralesional injection of bleomycin and were recalled after 4 weeks for evaluation. Colour photographs of the patients were taken before the onset of treatment and at each monthly visit, and were utilized to assess the response. Following the second, third, and fourth doses, the response was better in patients with the macrocystic variant than in those with the other two variants. However, after the completion of six doses, 80.3% of patients with the macrocystic variant, 67.4% with the microcystic variant, and 71.4% with the mixed type had a complete response. There was no difference in the overall response between the three types (P=0.28). Oedema, erythema, and local induration with fever were the most common adverse effects and were more common in younger children.

There is no quality metric for emergency physicians' diagnostic time for acute coronary occlusion.

We sought to quantify diagnostic time associated with automated interpretation, classic ST-elevation myocardial infarction (STEMI) criteria, STEMI-equivalents, and subtle occlusions, using electrocardiogram (ECG)-to-activation of catheterization laboratory time.

This multicenter retrospective study reviewed all code STEMI patients from the emergency department (ED) with confirmed culprit lesions from January 2016 to December 2018. We measured door-to-ECG (DTE) time and ECG-to-activation (ETA) time. We examined the first ED ECGs to determine whether automated interpretation labeled "STEMI," and they met classic STEMI criteria, STEMI-equivalents, or rules for subtle occlusion. ECG analysis was performed by two emergency physicians blinded to clinical scenario, automated interpretation, and angiographic outcome.

There were 177 code STEMIs with culprit lesions, with a median DTE time of 9.0min and a median ETA time of 16.0min. Automated interpretation labeled 55.4% of first ECGs "STEMI" (ETA 6.5min) and 44.6% not "STEMI" (ETA 66min, p<0.0001). Of first ECGs, 63.8% met classic STEMI criteria (ETA 8.0min), 8.5% had STEMI-equivalents (ETA 32.0min, p=0.0026), 16.4% had subtle occlusions (ETA 89.0min, p=0.045), and 11.3% had no diagnostic sign of occlusion (ETA 68.0min, p=0.20).

STEMI criteria missed more than one-third of occlusions on first ECG, but most had STEMI-equivalents or rules for subtle occlusion. ETA time can serve as a quality metric for emergency physicians to promote new ECG insights and assess quality improvement initiatives.

STEMI criteria missed more than one-third of occlusions on first ECG, but most had STEMI-equivalents or rules for subtle occlusion. ETA time can serve as a quality metric for emergency physicians to promote new ECG insights and assess quality improvement initiatives.

Empyema necessitans is a rare complication of pleural empyema characterized by the dissection of pus through the soft tissues of the chest wall and eventually through the skin. The skin manifestation may appear as a superficial abscess.

A 63-year-old woman presented to the Emergency Department (ED) with a chief complaint of dyspnea, dry cough, and a cutaneous nodule on her right chest wall. Three weeks prior to her ED visit, she underwent an exploratory thoracotomy and chest tube placement. The chest tube was removed 2weeks later. Her physical examination was significant for decreased breath sounds over her right lung fields and a painful, fluctuant, and erythematous nodule on the right chest wall where the chest tube had previously been inserted. Externally, the dermal findings appeared to be a superficial abscess. A chest X-ray study showed a large pleural effusion in her right hemithorax. Point-of-care ultrasound (POCUS) performed by an emergency physician showed evidence of a tract extending from the gs appeared to be a superficial abscess. A chest X-ray study showed a large pleural effusion in her right hemithorax. Point-of-care ultrasound (POCUS) performed by an emergency physician showed evidence of a tract extending from the nodule toward the pleural space that led to the correct diagnosis and treatment of empyema necessitans. WHY SHOULD AN EMERGENCY PHYSICIAN BE AWARE OF THIS? It is important to distinguish between a superficial abscess, which requires local drainage, and empyema necessitans, which requires either chest tube drainage, open drainage, or even decortication in specific cases. In such cases, POCUS can facilitate a rapid, accurate diagnosis, and lead to the correct treatment.