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ecial education centers' supplementary curriculum and training materials, making new enhancements and improvements possible in the future.

Both the educators and the children with SpLD enjoyed playing the games, gave positive feedback, and suggested new ways for improvement. The results showed that these games provide thorough training material for different types of SpLD with personalized and tailored difficulty systems. The final version of the proposed games will become a part of the special education centers' supplementary curriculum and training materials, making new enhancements and improvements possible in the future.

Pituitary adenoma is one of the most common central nervous system tumors. The diagnosis and treatment of pituitary adenoma remain very difficult. Misdiagnosis and recurrence often occur, and experienced neurosurgeons are in serious shortage. A knowledge graph can help interns quickly understand the medical knowledge related to pituitary tumor.

The aim of this study was to develop a data fusion method suitable for medical data using data of pituitary adenomas integrated from different sources. The overall goal was to construct a knowledge graph for pituitary adenoma (KGPA) to be used for knowledge discovery.

A complete framework suitable for the construction of a medical knowledge graph was developed, which was used to build the KGPA. The schema of the KGPA was manually constructed. Information of pituitary adenoma was automatically extracted from Chinese electronic medical records (CEMRs) and medical websites through a conditional random field model and newly designed web wrappers. An entity fusion method is proposed based on the head-and-tail entity fusion model to fuse the data from heterogeneous sources.

Data were extracted from 300 CEMRs of pituitary adenoma and 4 health portals. Entity fusion was carried out using the proposed data fusion model. The F1 scores of the head and tail entity fusions were 97.32% and 98.57%, respectively. Triples from the constructed KGPA were selected for evaluation, demonstrating 95.4% accuracy.

This paper introduces an approach to fuse triples extracted from heterogeneous data sources, which can be used to build a knowledge graph. The evaluation results showed that the data in the KGPA are of high quality. The constructed KGPA can help physicians in clinical practice.

This paper introduces an approach to fuse triples extracted from heterogeneous data sources, which can be used to build a knowledge graph. The evaluation results showed that the data in the KGPA are of high quality. The constructed KGPA can help physicians in clinical practice.

The development of an author-level complementary metric could play a role in the process of academic promotion through objective evaluation of scholars' influence and impact.

The objective of this study was to evaluate the correlation between the Healthcare Social Graph (HSG) score, a novel social media influence and impact metric, and the h-index, a traditional author-level metric.

This was a cross-sectional study of health care stakeholders with a social media presence randomly sampled from the Symplur database in May 2020. We performed stratified random sampling to obtain a representative sample with all strata of HSG scores. We manually queried the h-index in two reference-based databases (Scopus and Google Scholar). Continuous features (HSG score and h-index) from the included profiles were summarized as the median and IQR. We calculated the Spearman correlation coefficients (ρ) to evaluate the correlation between the HSG scores and h-indexes obtained from Google Scholar and Scopus.

A total of 28l complementary metric and the h-index. More than a chiasm between traditional citation metrics and novel social media-based metrics, our findings point toward a bridge between the two domains.Autoimmune encephalitis is increasingly recognised as a major cause of new-onset refractory status epilepticus. Early immunotherapy with agents such as methylprednisolone is recommended. Anakinra is an interleukin-1 receptor antagonist used for various inflammatory disorders. It has been used successfully in the treatment of febrile infection-related epilepsy syndrome in children and in one adult case. In this case report, we describe a case of super-refractory status epilepticus in a 38-year-old female due to autoimmune encephalitis who was treated successfully with anakinra after 16 weeks of therapeutic coma and failing multiple immunotherapies. Despite a prolonged period of therapeutic coma, this patient made a reasonable recovery with effective communication and ability to walk with assistance upon discharge. We propose that the successful treatment with anakinra in our case could be due to elevated inflammatory cytokines in the pathogenesis of autoimmune encephalitis, although we acknowledge that interleukin levels were unfortunately not available. We conclude that anakinra can be a valuable alternative option in patients with autoimmune encephalitis refractory to conventional immunotherapies.The aim of the current study was to investigate the opinions of neurologists and psychiatrists in Iran on the necessity of COVID-19 vaccination in patients with epilepsy (PWE). These data can help policy makers understand the concerns of these healthcare professionals. This was a survey study. On September 1st, 2020 we sent a questionnaire (using Google-forms) to all neurologists and psychiatrists in Iran via WhatsApp. The survey included three general questions (age, sex, and discipline) and six COVID-specific questions. In total, 202 physicians participated in this study (116 neurologists and 86 psychiatrists). Of the participants, 27% believed that PWE are at increased risk of contracting COVID-19. The majority (74%) of the participants would confidently recommend COVID-19 vaccine to their patients. However, only 49% of the physicians would recommend such a vaccine to all patients; others would consider it in special populations only. The overwhelming majority (91%) of the participants would recommend COVID-19 vaccine only when a reliable vaccine becomes available. Many physicians would trust a vaccine that is approved by the World Health Organization (WHO) (46%) or a vaccine that is approved by the Food and Drug Administration (FDA-USA) (34%). Physicians have concerns on the issue of the necessity of (a future) COVID-19 vaccine in PWE. The most important concern is the reliability of a vaccine and in this regard, two health agencies, the WHO and the FDA, are the most trusted organizations to approve a vaccine against COVID-19.

The increased incidence of cancer with age and rise of oral chemotherapy will affect the management of nursing home's residents. The aim of our study was to evaluate knowledge and practices in oncogeratric of nursing home's professionals from Pays-de-la-Loire and to raise awareness.

In partnership with UCOG-pl, OMEDIT and Observatoire du Cancer, we realised an observational survey from April to September 2017. Three questionnaires were sent to coordonary doctors (CD), nurses and paramedics, along with informative documents.

In 589nursing homes, 82 CD, 147 nurses and 240 paramedics gave an answer. The estimation of cancer's prevalence was 8,75%. Breast and prostate cancers were the most frequent. Nursing homes were an appropriate place to screen cancers by 79% of professionals. Some difficulties were reported by more than 80% of them (coordination, residents' relationships...). At least, 20% of professionals couldn't define properly oncogeriatric. Only 73% of CD, 16% of nurses and 5% of paramedics knew ag homes could partly explain by the lake of training, communication and coordination with oncology professionals and the distinctive characteristics of nursing home's residents. Study suggests that raising awareness of oncogeriatric and its challenges to all professionals would improve the care of the elderly with cancer.

Episodic memory is the most affected memory system in aging. However, memory decline is not similar in every older adult. ASN-002 nmr Various cognitive reserve factors, as Openness personality trait or educational level, and cognitive resources linked to these factors, as executive control and crystallized knowledge, can predict older adults' memory performance.

This study examined the link between and the role of these variables in older adults' memory performances according to the task difficulty.

Forty participants (60-82years old) learned 24paired words with two encoding conditions (reading and generation) and then performed a cued recall. Their educational level was asked, and their Openness, executive control and crystallized knowledge levels were respectively measured using a personality questionnaire (Big Five), an inhibition test (Stroop) and a vocabulary test (Mill Hill).

Only crystallized knowledge predicts older adults' generated words recall while Openness and executive control predict and mediate educational level effect on older adults' read words recall.

Openness is a reserve factor and is an essential component, along with executive control, in difficult memory tasks.

Openness is a reserve factor and is an essential component, along with executive control, in difficult memory tasks.

The incidence of type 1 diabetes mellitus (T1DM) and hypothyroidism as immune-related adverse events (irAEs) after programmed cell death-1 inhibitor (PD-1i) administration has not yet been sufficiently evaluated in a real clinical setting. To assess the incidence of T1DM and hypothyroidism among PD-1is and to identify the risk factors associated with hypothyroidism using a large claims database.

This cohort study used the Shizuoka Kokuho database in Japan from 2012 to 2018, including approximately 2.2 million people. We enrolled 695 PD-1i-treated patients. T1DM and hypothyroidism as irAEs were identified using International Classification of Diseases 10th Revision and Anatomical Therapeutic Chemical classification codes. Risk factors for hypothyroidism were explored using the multivariable Fine and Gray regression model after adjusting for age group and sex, treating death as a competing risk.

The cumulative incidences of T1DM and hypothyroidism were 0.3% and 8.3%, respectively. We described the detailed onset timing of irAEs in patients with T1DM and hypothyroidism; hypothyroidism was observed evenly within 1 year of the PD-1i prescription. Sex and certain cancer types, such as lung and urothelial cancers, were significantly associated with subdistribution hazard ratio (sHR) (female sHR, 2.04 [95% CI, 1.20-3.47]; lung cancer sHR, 0.55 [95% CI, 0.32-0.95]; and urothelial carcinoma sHR, 2.40 [95% CI, 1.05-5.49]).

The incidence of T1DM and hypothyroidism as irAEs and associated risk factors identified in this analysis were comparable to those found in previous studies. The use of a large claims database to detect irAEs, such as T1DM and hypothyroidism, may lead to safer use of PD-1is.

The incidence of T1DM and hypothyroidism as irAEs and associated risk factors identified in this analysis were comparable to those found in previous studies. The use of a large claims database to detect irAEs, such as T1DM and hypothyroidism, may lead to safer use of PD-1is.