Abelhensley4335
these may be guiding for determining the tumour depth. Key Words Gastric adenocarcinoma, CD44, CD133, Stem cell marker, Prognosis.
We aimed to determine the predictive significance of Ki-67and platelet lymphocyte ratio (PLR) in patients with gastric cancer (GC), who received fluorouracil, leucovorin, oxaliplatin, docetaxel (FLOT) as neoadjuvant chemotherapy (NAC).
Descriptive study.
Department of Medical Oncology, Faculty of Medicine, Ondokuz Mayıs University, Samsun, Turkey from March 2016 to January 2020.
Seventy-five patients with GC, who received FLOT treatment as NAC were included in the study. Ki-67 and PLR, which were examined pre-NAC and aft-NAC, were recorded. Associations between clinical-histopathological parameters with disease-free survival (DFS) and overall survival (OS) were analysed using Kaplan-Meier curves. Cox-regression analysis was used to assess their prognostic values.
There was a statistically significant difference between pre-NAC and aft-NAC Ki-67, and aft-NAC PLR values between groups with complete response, partial response, and stable disease aft-NAC (p 0.023, p <0.001; and p 0.001, respectively). When the patients were grouped according to the pre-NAC and aft-NAC Ki-67 changes, a significant difference was found in terms of OS (p< 0.001). High pre-NAC and high aft-NAC Ki-67 were associated with shorter DFS and OS (p 0.042, p 0.049; p 0.027, and p 0.001, respectively). The high pre-NAC PLR was associated with shorter OS, while the high aft-NAC PLR was associated with shorter DFS (p 0.018, and p 0.001, respectively). In multivariate analysis, aft-NAC Ki-67 was found to be an independent prognostic factor for OS.
Ki-67 and PLR have predictive significance in GC patients treated with neoadjuvant FLOT. Ki-67 is an independent prognostic marker for OS in gastric cancer. Key Words FLOT, Gastric cancer, Ki-67, Platelet lymphocyte ratio.
Ki-67 and PLR have predictive significance in GC patients treated with neoadjuvant FLOT. Ki-67 is an independent prognostic marker for OS in gastric cancer. Key Words FLOT, Gastric cancer, Ki-67, Platelet lymphocyte ratio.
To compare the difference in the effect on pregnant women and fetuses between very advanced maternal age (age of or over 45 years) and other ages (age below 45 years).
A descriptive study.
Changyi People's Hospital, China, from June 2017 and September 2020.
Four-hundred singleton pregnancies were selected. One hundred and three pregnant women at age of or over 45 years (Group A) and 297 pregnant women at age below 45 years (Group B) were grouped by age. Serum total cholesterol (TC), triglyceride (TG), high density lipoprotein cholesterol (HDL-C) and low density lipoprotein cholesterol (LDL-C), incidence of pregnancy complications and fetal outcomes were compared.
Group A had higher TC and HDL-C than Group B at 12-week, 32-week pregnancy and 3 days after delivery (all p <0.001); Group A had higher TG than Group B at 12-week, 32-week pregnancy and 3 days after delivery (p=0.003, p <0.001 and p <0.001), respectively. Group A had higher incidence of gestational diabetes mellitus (GDM), pregnancy complicated with leiomyoma, gestational hypertension, placenta previa, placental abruption, anemia and postpartum hemorrhage than Group B (all p <0.001). Group A had higher incidence of fetal distress and preterm birth than Group B (both p <0.001). The difference in fetal weight and Apgar score of 5-min infants compared between the two groups was significant (both p<0.001).
The incidence of gestational complications and adverse perinatal outcomes may be increased in very advanced maternal age singleton pregnant women aged over 45 years. Key Words Very advanced maternal age, Pregnant women, Pregnancy, Fetus, Complications.
The incidence of gestational complications and adverse perinatal outcomes may be increased in very advanced maternal age singleton pregnant women aged over 45 years. Key Words Very advanced maternal age, Pregnant women, Pregnancy, Fetus, Complications.
To evaluate the relationship of C-reactive protein (CRP)/albumin ratio (CAR), neutrophil/lymphocyte ratio (NLR), platelet/lymphocyte ratio with Bath Ankylosing Spondylitis Disease Activity Index (BASDAI) in axial spondyloarthritis (Ax-SpA).
Cross-sectional study.
Clinic of Rheumatology, Dışkapı Education and Research Hospital, Health Sciences University, Turkey during January 2020-2021.
One-hundred and nine patients aged >18 years were included. Age, gender, duration of disease, BASDAI scores were recorded. CRP, erythrocyte sedimentation rate (ESR), albumin values, leukocyte, neutrophil, lymphocyte, platelet counts were determined.
The mean age and median disease duration of the patients were 45.03±10.63 and 5 (2-6.5) years, respectively. Among these, 28 (58.3%) female and 44 (72.1%) male patients were found to be HLA-B27 positive. BASDAI≥ 4 was observed in 61 (56%) patients and <4 in 48 (44%) patients. CRP, albumin, ESR, NLR and CAR values between the patient groups were significantly differeetabolism, Serum albumin/metabolism, Neutrophils, Lymphocytes, Platelet count.
To determine the outcome of Stereotactic Body Radiation Therapy (SBRT) and its prognostic factors among hepatocellular carcinoma (HCC) patients.
Descriptive study.
Department of Radiology and Cyberknife Robotic Radiosurgery, Jinnah Postgraduate Medical Centre (JPMC), Karachi, Pakistan from 1st July 2019 to 31st August 2020.
All patients of either gender age 18 years and above presenting with pathological confirmation of HCC, ECOG performance status of ≤2 and child Pugh A or B were consecutively enrolled. Progression of >20% was defined as progressive disease (PD). SBRT was performed using the Cyberknife. Clinical outcome was measured in terms of progression free survival. Moreover, radiation induced toxicity was also observed along with other predictor variables. Results Of 52 patients, the median age was 58 (53-59) years. There were 42 (80.8%) males and 10 (19.2%) females. All patients were alive at 3 months, i.e. 52 (100%). However, at 6 months, 49 (94.2%) were alive, at 9 months, 38 (73.1%) patients were alive while at 1 year, 24 (46.2%) patients were alive. A significant association was observed for survival at 6 months and ECOG performance status score (p-value 0.036), survival at 9 months and AFP (p= 0.003), survival at 1 year and age (p = 0.019), survival at 1 year and HBV (p = 0.001), and survival at 1 year and previous treatment (p = 0.010). Moreover, none of the patients reported complications / radiation induced liver toxicity.
A higher efficiency of SBRT was found among HCC patients attending Radiology Department. Key Words Stereotactic body radiation therapy, Hepatocellular carcinoma, Toxicity, Survival.
A higher efficiency of SBRT was found among HCC patients attending Radiology Department. Key Words Stereotactic body radiation therapy, Hepatocellular carcinoma, Toxicity, Survival.
To find the association of serum hyaluronic acid and laminin levels with polymerase chain reaction (PCR) results in hepatitis C sero-positive patients; and the correlation among viral load, serum hyaluronic acid, and serum laminin levels.
Cross-sectional descriptive study.
Department of Chemical Pathology and Endocrinology, Armed Forces Institute of Pathology (AFIP), Rawalpindi, Pakistan from December 2019 to July 2020.
One hundred and eighty diagnosed cases of hepatitis C patients were included in this study. To find association, cross tabulation was done after dividing into two groups according to their median by applying Chi-square test. Correlation of viral load, duration of disease, serum hyaluronic acid and laminin levels were calculated using Spearman's correlation.
There were 124 (68.9%) males and 56 (31.1%) females. Median (IQR) age was 36 (32.3 - 45.0) years; while median duration of disease was 12 (8 - 18) months. There was a strong association between PCR positive cases with hyaluronic acid (p <0.001) and serum laminin levels (p <0.001). A strong relationship was found between viral load and serum hyaluronic acid (r =0.889, p <0.001), as well as with serum laminin (r =0.889, p <0.001).
Current study established a strong significant association between PCR results and disease duration with levels of serum laminin and hyaluronic acid. The levels of serum laminin and serum hyaluronic acid also correlate well with viral load and duration of disease. Key Words Hepatitis C, Hepatic fibrosis, Hyaluronic acid, Laminin.
Current study established a strong significant association between PCR results and disease duration with levels of serum laminin and hyaluronic acid. The levels of serum laminin and serum hyaluronic acid also correlate well with viral load and duration of disease. Key Words Hepatitis C, Hepatic fibrosis, Hyaluronic acid, Laminin.
To compare the IVF outcome of patients assumed to be poor responders before their first cycle treated by microdose flare-up or GnRH antagonist protocols with patients who had a poor ovarian response after their first cycle stimulated with long GnRH protocol.
Observational cohort study.
Department of Obstetrics and Gynecology, IVF Unit of Gazi University Faculty of Medicine, from September 2014 to February 2019.
Patients treated with the first cycle of IVF and diagnosed as poor responders after ovarian stimulation were evaluated according to the treatment protocol, including microdose flare-up (Group 1 136 patients), GnRH antagonist (Group 2 105 patients), and long GnRH agonist (Group 3 77 patients).
Basal FSH level was significantly lower in group 3 compared to other groups (p<0.05). The number of oocytes retrieved, the number of metaphase II oocytes were similar between groups, although the mean AFC was significantly higher in group 3 than in group1 and 2 (p<0.05). Clinical pregnancy rates per patient were higher in group 3 (20.8%) than in group 1 (12.5%) and group 2 (13.3%), but the difference was not statistically significant (p=0.230). The live birth rate per patient was statistically higher in group 3 (19.5%) as compared to other groups (8.8%, 9.5%, respectively; p<0.05).
Long protocol may be an option in poor responders undergoing IVF. Ovarian reserve markers are essential factors with stimulation protocol for the success of IVF in poor responder patients. Key Words Infertility, Ovulation ınduction, Ovarian reserve, Fertilisation in-vitro, Oocyte retrieval, Pregnancy outcome, Reproductive techniques, Assisted.
Long protocol may be an option in poor responders undergoing IVF. PFK158 PFKFB inhibitor Ovarian reserve markers are essential factors with stimulation protocol for the success of IVF in poor responder patients. Key Words Infertility, Ovulation ınduction, Ovarian reserve, Fertilisation in-vitro, Oocyte retrieval, Pregnancy outcome, Reproductive techniques, Assisted.
To determine the relationship between the positivity of third-generation TSH receptor antibody (TRAb) at the time of diagnosis and the cumulative methimazole dose used until remission in patients with Graves' disease.
Cross-sectional, descriptive study.
Department of Endocrinology and Metabolic Diseases, University of Health Sciences, Kartal Dr. Lütfi Kırdar City Hospital, Turkey from 2016 to 2018.
Newly diagnosed Graves' patients were included in the study. The patients were divided into two groups according to whether they entered remission (n 21) or not (n 20), in the 18th month of methimazole treatment. In addition, the patients were further divided into two categories, according to TRAb status at the time of diagnosis as negative (n 17) or positive (n 24). The TRAb positivity and the cumulative methimazole dose they used until the month of remission were compared in these groups.
The mean time to reach remission in 41 patients was 20.5 ± 3.1 months. TSH receptor antibody positivity rate was 58.
