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The care of people with mental health problems requires health system and service reforms to build up proper mental health care. click here The challenges of the present moment continue to be immense. The viral pandemic that we are experiencing has exposed the fragility of our health and social services and certified the inequality and precariousness of the living conditions of many people. The collection of articles published in the journal Salud Colectiva as part of the open call for papers "Mental health and human rights challenges for health services and communities," includes articles from Spain, Brazil, Mexico, and Chile. These papers present conceptual experiences and reflections on community action plans and programs, contributing toward better knowledge and development of mental health in the region.Using information from the mortality database at Chile's Department of Statistics and Health Information (Ministry of Health), an ecological time-series study was conducted to determine changing trends in suicide rates by sex and age group in Chile from 1997 to 2018. Results show that the mortality rate for men in 2018 was 20.1 per 100,000, almost five times higher than the rate for women. Trends in both sexes show a decrease in aver-age annual percent change of -5.4% [CI95% (-12.9; 1.9)] between 2009 and 2013. Over the same period, the average annual percent change for men was -5.8% [CI95% (-12.5; 2.3)], while for women it was -4.0 [CI95% (-5.8; -2.2)] between 2008 and 2018. No changes have been observed in trends for men aged 60 and over, the group with the high-est rates. Although suicide rates declined following the implementation of policies focus-ing on risk factors for suicide, it is necessary to evaluate the implementation of these pol-icies and devise similar actions geared toward populations with greater risk of suicide.

Who disrupts who? It is not clear what the interaction is between a high calorie diet (HCD) and adrenal axis activation in obesity. The goal was to assess the effect of two hypercaloric diets commercialized in Algeria on the hormonal and metabolic profile of the adrenal gland in rabbits.

Two classes of local male adult rabbits (n=16) and a finishing diet (FD) as a control for 15weeks.

It has been shown that HCD-received animals have developed visceral obesity, dyslipidemia and insulin resistance IR by dramatically increasing body weight, visceral fat tissue and adrenal weight, combined with elevated plasma levels of ACTH, cortisol, leptin and insulin. The HCD diet increased the levels of cortisol in the visceral adipose tissue (VAT), in peri-adrenal adipose tissue (PAAT), and decreased cortisol levels in the liver. HCD also causes the process of inflammatory fibrosis associated with the migration and spread of chromaffin cells in the adrenal gland.

This study gives new insights into how diet-induced obesity studied on local rabbits affects the biology of the adrenal gland. The correlation of these changes with paracrine connections between the chromaffin cell and glomerulosa indicates potential therapeutic methods for obese-related steroid hormone dysfunction.

This study gives new insights into how diet-induced obesity studied on local rabbits affects the biology of the adrenal gland. The correlation of these changes with paracrine connections between the chromaffin cell and glomerulosa indicates potential therapeutic methods for obese-related steroid hormone dysfunction.

The present study aimed to explore the effect of water-based rhythmic exercise training on fasting blood sugar (FBS), homeostatic model assessment (HOMA), insulin, thyroid stimulating hormone (TSH), and T4 in postmenopausal women with metabolic syndrome.

In this clinical trial, 31 postmenopausal woman with metabolic syndrome aged 69.16±2.02 years were randomly assigned to an experimental (n=16) and a control group (n=15). The training program was composed of 12 weeks of water-based rhythmic exercise training performed intermittently for 60min three times a week. Before and after training, blood was analyzed for glucose homeostasis, T4, and TSH. Data were subjected to analysis by paired t-test and covariance analysis at the p<0.05 level.

The exercise training intervention reduced the FBS and insulin significantly (p=0.000). The growth hormone (GH) index was increased significantly only in the experimental group (p=0.037) whereas no significant variations occurred in the insulin-like growth factor-1 (p=0.712). It was also found that TSH and T4 change in the experimental group as compared to the pre-test.

Water-based rhythmic exercise training may improve blood glucose homeostasis, TSH, and T4.

Water-based rhythmic exercise training may improve blood glucose homeostasis, TSH, and T4.The emergence of antibacterial resistance has significantly increased. Pseudomonas aeruginosa is associated with nosocomial infection and difficult to control. Artocarpin, a flavonoid from Artocarpus heterophyllus Lam. exhibits several pharmacological properties including antibacterial. The study was performed to evaluate interaction between artocarpin and antibiotics including tetracycline against P. aeruginosa. Its mechanism of action on membrane permeability was also investigated. Broth microdilution was conducted for the susceptibility assay. The interaction of artocarpin and antibiotics was evaluated using checkerboard method, the effect on alteration of membrane cell was investigated using bacteriolysis and the released of 260 nm materials. Artocarpin showed moderate to weak activity against the Gram-negative bacteria including P. aeruginosa with MIC values in the range of 31.25-250 μg/mL. A synergistic effect against P. aeruginosa was produced by the combination of artocarpin (31.25 μg/mL) and tetracycline (1.95 μg/mL) with FICI of 0.37. The time-killing assay showed that artocarpin enhance the antibacterial activity of tetracycline against P. aeruginosa by completely inhibiting the bacterial growth. Additionally, the mixture of artocarpin (31.25 μg/mL) and tetracycline (1.95 μg/mL) disrupted membrane permeability and lead to cell death. These results proposed that the combination of artocarpin and tetracycline may be used to overcome P. aeruginosa infection.