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cation skills. However, significant results were not found between psychological distress and problematic social network use. Therefore, it is necessary to perform additional studies that would further explore this aspect. This study allows us to explore the negative impact of social networks on therapeutic communication, with the aim of developing prevention strategies at university institutions.This position statement describes the recommendations of the Clinical Oncology Society of Australia (COSA) regarding management of cancer-related malnutrition and sarcopenia. A multidisciplinary working group completed a review of the literature, focused on evidence-based guidelines, systematic reviews and meta-analyses, to develop recommendations for the position statement. National consultation of the position statement content was undertaken through COSA members. All people with cancer should be screened for malnutrition and sarcopenia in all health settings at diagnosis and as the clinical situation changes throughout treatment and recovery. People identified as "at risk" of malnutrition or with a high-risk cancer diagnosis or treatment plan should have a comprehensive nutrition assessment; people identified as "at risk" of sarcopenia should have a comprehensive evaluation of muscle status using a combination of assessments for muscle mass, muscle strength and function. All people with cancer-related malnutrition and sarcopenia should have access to the core components of treatment, including medical nutrition therapy, targeted exercise prescription and physical and psychological symptom management. Treatment for cancer-related malnutrition and sarcopenia should be individualised, in collaboration with the multidisciplinary team (MDT), and tailored to meet needs at each stage of cancer treatment. Health services should ensure a broad range of health care professionals across the MDT have the skills and confidence to recognise malnutrition and sarcopenia to facilitate timely referrals and treatment. The position statement is expected to provide guidance at a national level to improve the multidisciplinary management of cancer-related malnutrition and sarcopenia.
Bruton's tyrosine kinase (BTK) is important in B-cell signalling. Efficacy has been reported for BTK inhibitors (BTKi) in human autoimmune diseases. Canine pemphigus foliaceus (cPF) is one of the most common canine autoimmune skin diseases.
To determine the safety and efficacy of the BTKi PRN1008 in the treatment of cPF.
Four privately owned dogs.
Four dogs diagnosed with PF were administered BTKi PRN1008. Initial dosages approximated to 15mg/kg once daily, increased to twice daily if inadequate response was seen. UBCS039 Treatment continued for 20 weeks, attempting to decrease to every other day. Dogs were monitored with complete blood counts, serum biochemistry panels and urinalyses, and evaluated with a modified version of a validated human Pemphigus Disease Activity Index (cPDAI). Serum anti-desmocollin-1 (DSC-1) and desmoglein-1 (DSG-1) immunoglobulin (Ig)G titres were performed before and after the treatment period. Drug bound to target was measured in peripheral blood mononuclear cells (PBMC).
All four dogs showed reduction in lesions and cPDAI score during the first two weeks of treatment. Three dogs continued to improve and sustained near complete remission by 20 weeks, at which point three responses were considered "good" and one "fair". Final daily dosages were in the range 17-33mg/kg. Anti-DSC-1 IgG titre decreased dramatically in one dog, was undetectable in two and was uninterpretable in one dog. No dogs had detectable IgG to DSG1. A possible adverse event occurred in one dog.
BTKi PRN1008 monotherapy may have some beneficial effects in some cases of cPF.
BTKi PRN1008 monotherapy may have some beneficial effects in some cases of cPF.
To examine whether the presence of a mobile phone has a moderating role in the relationship between nurses' private life telepressure and workplace cognitive failure.
Cross-sectional quantitative study using self-report questionnaires.
Data were collected between December 2019 - January 2020. In total, 849 Registered Nurses from three Belgian hospitals completed the online survey. Data were analysed with hierarchical regression analyses and simple slope tests.
Overall, the positive relationship between private life telepressure and workplace cognitive failure was moderated by mobile phone presence. Specifically, the experience of private life telepressure did only relate to higher workplace cognitive failure when nurses kept their mobile phone nearby (i.e. in their pockets). Additional exploratory analyses revealed that this moderation effect only held among nurses in young adulthood and regardless of the notification settings of their mobile phone.
The present findings indicate the unintended risk understanding is necessary on how these devices might distract personnel in a healthcare setting. The present study gives further insight into this topic and shows that in particular nurses in young adulthood who experience telepressure towards personal messages report more cognitive failure when their personal mobile phones are present, even when they do not actually use these devices. This furnishes additional evidence in support of hospitals' formal policy to forbid personal mobile phones of healthcare personnel when at work.The correlation between pedigree and genomic-based inbreeding coefficients is usually discussed in the literature. However, some of these correlations could be spurious. Using partial correlations and information theory, it is possible to distinguish a significant association between two variables which is independent from associations with a third variable. The objective of this study is to implement partial correlations and information theory to assess the relationship between different inbreeding coefficients using a selected population of rabbits. Data from pedigree and genomic information from a 200K SNP chip were available. After applying filtering criteria, the data set comprised 437 animals genotyped for 114,604 autosomal SNP. Fifteen pedigree- and genome-based inbreeding coefficients were estimated and used to build a network. Recent inbreeding coefficient based on runs of homozygosity had 9 edges linking it with different inbreeding coefficients. Partial correlations and information theory approach allowed to infer meaningful associations between inbreeding coefficients and highlighted the importance of the recent inbreeding based on runs of homozygosity, but a good proxy of it could be those pedigree-based definitions reflecting recent inbreeding.
