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vasica could be promising leads for the design of Eicosanoid pathway modulators/inhibitors.Communicated by Ramaswamy H. Sarma.Recent literature has highlighted the role of social support in improving self-esteem. This study aimed to measure self-esteem and its association with social support among married women aged 30-75 years, in Riyadh city, Saudi Arabia. A cross-sectional survey was conducted during 2015-2016, on 1883 married Saudi women visiting the primary health care centers. Female data collectors conducted questionnaire-based interview and took anthropometric measurements. Self-esteem and social support were measured by utilizing the Rosenberg self-esteem scale and social support survey scale, respectively. The majority of women reported moderate to high levels of self-esteem. Multivariate linear regression analysis found that one unit increase in availability of emotional support, education, and physical activity were significantly associated with 0.18 (0.22, 0.39, p less then .001), 0.17 (0.26, 0.48, p less then .001) and 0.09 (0.39, 1.13) increase in self-esteem scores, respectively. Similarly, a unit increase in tangible support, education and physical activity were significantly associated with 0.20 (0.27, 0.44, p less then .001), 0.17 (0.26, 0.47, p less then .001), and 0.07 (0.17, 0.89) unit increase in self-esteem scores, respectively. The results highlight the importance of emotional and tangible support associated with high self-esteem. We recommend that social support groups should be created for providing counseling and support to the socially isolated women with low self-esteem.Objectives. Team manual handling, a process still common in many jobs, can affect the safety and health of employees. A systematic review of the literature was conducted to identify the research gaps in this area for future studies. Methods. The Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) methodology was followed. Related papers were searched on PubMed, Web of Science, ProQuest and Scopus electronic databases until September 2020. Results. A total of 300 papers were identified, of which 28 were selected for final review based on the respective criteria. The findings of these studies were classified and evaluated based on biomechanical, physiological and psychophysical approaches. No study was found for the epidemiological approach. Only three papers mentioned the body physiological responses in team manual handling. VPS34-IN1 concentration The focus of the related studies found in this field was team lifting. No study was found on team pulling and pushing. link2 Most studies were performed in a laboratory setting using young students who had no experience of team manual handling. Conclusion. The results of this study emphasize the need for further research, especially using the epidemiological and physiological approaches in different tasks of team manual handling in real work environments using experienced workers.Music and metronomes differentially impact movement performance. The current experiment presented metronome and drum beats in simple and complex rhythms before goal-directed reaching movements, while also quantifying enjoyment. link3 Auditory conditions were completed with and without visual feedback and were blocked and counterbalanced. There were no differences between simple and complex rhythms, indicating that rhythmic information alone is sufficient to benefit performance. The drum elicited shorter movement times and higher peak velocities, without an increase in spatial variability. Reaction times were moderately correlated with ratings of enjoyment. These data provide evidence that the source of an auditory stimulus impacts movement performance of a goal-directed reaching task. Results are contextualized within models of goal-directed reaching to elucidate mechanisms contributing to performance improvements.Workers in swine operations may be at increased risk of developing respiratory problems. These respiratory conditions are more prevalent among workers who are smokers. Tumor necrosis factor (TNF) genes play an important role in human immune responses to various respiratory hazards. This study aimed to investigate whether polymorphisms in TNF genes might alter the effects of smoking on lung function among workers in swine operations. Three hundred and seventy-four full-time workers from large swine operations and 411 non-farming rural dwellers in Saskatchewan were included in this study. Information on demographic and lifestyle characteristics, pulmonary function, and blood samples were obtained. Multiple linear regression analyses were used in the statistical analysis. Three promoter polymorphisms (rs1799724, rs361525, and rs1800629) in the TNF gene were investigated. Only the interaction term between smoking status and rs1799724 was significant in the multiple regression models. Among workers with the rs1799724 polymorphism (TT+TC), current smokers exhibited significantly lower lung function than nonsmokers. These associations were not observed among workers with the wild-type (CC). These findings were not observed among non-farming rural dwellers. Data demonstrated the possible involvement of TNF gene in (1) development of adverse respiratory conditions among workers who are smokers, (2) importance of smoking cessation among workers, especially those with polymorphisms in the TNF gene, and (3) potential implications in treatment, screening, and prevention.Background The primary objective of this review was to explore the contribution of oxidative stress to the pathogenesis of genetically-triggered thoracic aortic aneurysm (TAA). Genetically-triggered TAAs manifest substantial variability in onset, progression, and risk of aortic dissection, posing a significant clinical management challenge. There is a need for non-invasive biomarkers that predict the natural course of TAA and therapeutics that prevent aneurysm progression.Methods An online systematic search was conducted within PubMed, MEDLINE, Scopus and ScienceDirect databases using keywords including oxidative stress, ROS, nitrosative stress, genetically triggered thoracic aortic aneurysm, aortic dilatation, aortic dissection, Marfan syndrome, Bicuspid Aortic Valve, familial TAAD, Loeys Dietz syndrome, and Ehlers Danlos syndrome.Results There is extensive evidence of oxidative stress and ROS imbalance in genetically triggered TAA. Sources of ROS imbalance are variable but include dysregulation of redox mediators leading to either insufficient ROS removal or increased ROS production. Therapeutic exploitation of redox mediators is being explored in other cardiovascular conditions, with potential application to TAA warranting further investigation.Conclusion Oxidative stress occurs in genetically triggered TAA, but the precise contribution of ROS to pathogenesis remains incompletely understood. Further research is required to define causative pathological relationships in order to develop therapeutic options.The endo-1,5-α-L-arabinanases, belonging to glycoside hydrolase family 43 (GH43), catalyse the hydrolysis of α-1,5-arabinofuranosidic bonds in arabinose-containing polysaccharides. These enzymes are proposed targets for industrial and medical applications. Here, molecular dynamics (MD), potential energy surface and free energy (potential of mean force) simulations are undertaken using hybrid quantum mechanical/molecular mechanical (QM/MM) potentials to understand the active site dynamics, catalytic mechanism and the electrostatic influence of active site residues of the GH43 endo-arabinanase from G. stearothermophilus. The calculated results give support to the single-displacement mechanism proposed for the inverting GH43 enzymes first a proton is transferred from the general acid E201 to the substrate, followed by a nucleophilic attack by water, activated by the general base D27, on the anomer carbon. A conformational change (2E ↔E3 ↔ 4E) in the -1 sugar ring is observed involving a transition state featuring an oxocarbenium ion character. Residues D87, K106, H271 are highlighted as potential targets for future mutation experiments in order to increase the efficiency of the reaction. To our knowledge, this is the first QM/MM study providing molecular insights into the glycosidic bond hydrolysis of a furanoside substrate by an inverting GH in solution.Communicated by Ramaswamy H. Sarma.Subcutaneous fat necrosis (SFN) in the newborn is a form of panniculitis which presents with erythematous nodules and indurated plaques. Severe life-threatening hypercalcaemia can occur as a late complication. A 2-month-old girl presented with severe hypercalcaemia and acute renal injury as a complication of SFN. She was admitted to hospital with the chief complaint of failure to thrive. She had a history of therapeutic hypothermia. After successful treatment of the hypercalcaemia with bisphosphonates, the acute renal injury recovered spontaneously. In neonates with SFN, acute renal injury is a rare complication of hypercalcaemia. Timely prevention of the complications of hypercalcaemia in SFN is essential.The antibacterial and antifungal effects of non-functionalized and surface-functionalized Mn3O4 nanoparticles were comparatively analyzed to reason out the potential changes in antimicrobial activities due to functionalization with 5-amino-2-mercapto benzimidazole (AMB) molecule. The surface functionalization of Mn3O4 nanoparticles with AMB molecule was confirmed by the XRD result, which shows the shift in 2θ values with noticeable peaks. The surface morphology and functionalization of Mn3O4 nanoparticles were additionally confirmed by HR-SEM and EDAX studies. Antimicrobial activities were investigated by an agar-well-diffusion method using the bacteria Staphylococcus aureus and Pseudomonas aeruginosa and fungi Aspergillus niger. The functionalized Mn3O4 nanoparticles possess remarkable antibacterial and antifungal effect than the non-functionalized Mn3O4 nanoparticles and AMB molecule. The coating of low energy surface layer over metal oxide nanoparticles such as Mn3O4 offers an active surface toward both transfer of electron and the adsorption or desorption of water, inorganic ions, and other molecules, which leads to the increased antimicrobial activity of f-Mn3O4 nanoparticles.Communicated by Ramaswamy H. Sarma.The ongoing global health crisis caused by Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2), the virus which leads to Coronavirus Disease 2019 (COVID-19) has impacted not only the health of people everywhere, but the economy in nations across the world. While vaccine candidates and therapeutics are currently undergoing clinical trials, there is a lack of proven effective treatments or cures for COVID-19. In this study, we have presented a synergistic computational platform, including molecular dynamics simulations and immunoinformatics techniques, to rationally design a multi-epitope vaccine candidate for COVID-19. This platform combines epitopes across Linear B Lymphocytes (LBL), Cytotoxic T Lymphocytes (CTL) and Helper T Lymphocytes (HTL) derived from both mutant and wild-type spike glycoproteins from SARS-CoV-2 with diverse protein conformations. In addition, this vaccine construct also takes the considerable glycan shield of the spike glycoprotein into account, which protects it from immune response.