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Yu, Todd, and Petrov (2021) and Yu, Petrov, and Todd (2021) investigated failures of shape constancy that occur when objects are viewed stereoscopically at different distances. Although this result has been reported previously with simple objects such as pyramids or cylinders, we examined more complex objects with bilateral symmetry to test the claim by Li, Sawada, Shi, Kwon, and Pizlo (2011) that the perception of those objects is veridical. Sawada and Pizlo (2022) offer several criticisms of our experiments, but they seem to suggest that the concept of shape is defined by what is computable by their model. If stimuli are used that cannot be discriminated by their model, they are dismissed as degenerate, and tasks that cannot be performed by their model are assumed to be based on something other than shape. This allows them to disregard empirical evidence that is inconsistent with their model. We argue, in contrast, that all reliable aspects of shape perception are deserving of explanation. We also argue that there are many different attributes of shape and many different sources of information about shape that may be relevant in different contexts. It is unlikely that all of them can be explained by a single model.Appropriations for the 2022 fiscal year increase NIH funding by 4.7% and raise NCI funding by 5.3%. The budget also includes $1 billion to launch the Advanced Research Projects Agency for Health, which will foster potentially groundbreaking research that could improve patient care.

Photoacoustic tomography (PAT) has demonstrated the ability to characterize molecular components and architectural heterogeneities of intraocular tumors in enucleated human globes and in animals in vivo. Although laser safety levels have been established for illumination through the cornea, the safety limit for PAT illumination through the sclera has not been investigated. The purpose of this study is to examine if the energy level used in intraocular PAT results in ocular damage.

Rabbit eyes were exposed to pulsed laser illumination at 20 mJ/cm2 at the scleral surface. Eyes were examined at 1, 7, and 28 days after the laser exposure. Examination procedures included white light and fluorescence fundus imaging, optical coherence tomography (OCT), electroretinography (ERG), and histology with hematoxylin and eosin (H&E) staining as well as terminal deoxynucleotidyl transferase-mediated deoxyuridine triphosphate nick-end labeling (TUNEL staining).

Fundus imaging and OCT of rabbit eyes at 1, 7, and 28 days following exposure of the laser illumination of the PAT system did not reveal any damage to the retinal structures. ERG showed no significant difference between the experimental and control eyes. Similarly, H&E histology did not show abnormalities in either the scleral tissue where the laser illumination was delivered or in the retinal layers. No sign of apoptosis in the layers of the retina, choroid, or optic nerve was found on TUNEL staining.

Similar to the application of PAT to other organs, the proposed laser illumination energy level at 20 mJ/cm2 does not impose detectable harm to the ocular tissue.

This study addresses illumination safety issues for PAT.

This study addresses illumination safety issues for PAT.

The purpose of this study was to compare the baseline steady-state pattern electroretinogram (SS-PERG) of patients with G11778A Leber hereditary optic neuropathy (LHON) with different stages of visual acuity (VA) loss before allotopic gene therapy (GT).

Patients (n = 28) were enrolled into groups (GT I chronic bilateral VA ≤35 Early Treatment Diabetic Retinopathy Study [ETDRS]; GT II acute bilateral VA ≤35 ETDRS; GT III acute unilateral, VA ≤35 ETDRS, and better eye VA ≥70 ETDRS) and tested with SS-PERG together with 210 age-matched normal controls (NCs). SS-PERG amplitude (nV) and latency (ms) of each eye were averaged for groups GT I, GT II, and NC. Symptomatic eyes (GT III-S) and asymptomatic eyes (GT III-A) of group GT III were included separately and accounted for by using generalized estimating equation (GEE) methods.

Compared to NC, SS-PERG amplitudes were reduced similarly by approximately 50% (P < 0.001) among all GT groups (NC > GT I, GT II, GT III-S, and GT III-A). SS-PERG latencies were shorter by ≥3.5 ms in all LHON groups and differed by disease stage (G III-A < NC, P = 0.002; GT III-S < GT III-A, P = 0.01; GT II < GT III-S, P = 0.03; GT I < NC, P < 0.001, but not different from other GT groups, all P > 0.1).

Although SS-PERG amplitude reduction did not distinguish between disease stages, SS-PERG latency shortening occurred in asymptomatic eyes and symptomatic eyes and distinguished between disease stages.

SS-PERG latency shortening is consistent with primary damage of smaller/slower axons and sparing of larger/faster axons and may provide an objective staging of LHON, which may be helpful to determine efficacy in LHON trials.

SS-PERG latency shortening is consistent with primary damage of smaller/slower axons and sparing of larger/faster axons and may provide an objective staging of LHON, which may be helpful to determine efficacy in LHON trials.

To assess the effect of low-level laser therapy (LLLT) on overall leveling and alignment time of mandibular anterior crowding and associated pain after initial archwire placement.

Thirty-two females (18-25 years) with mandibular anterior crowding were randomly allocated into laser and control groups. Eligibility criteria included Angle Class I molar relationship and Little's irregularity index (LII) from 4 to 10 mm. Randomization was accomplished with a computer-generated random list. A 0.014-inch copper-nickel-titanium (Cu-NiTi) wire was inserted immediately after bonding of 0.022-inch Roth brackets followed by 0.016-inch Cu-NiTi, 0.016 × 0.022-inch NiTi then 0.017 × 0.025-inch stainless steel wire after completion of alignment. In-Ga-As laser was applied to the mandibular anterior segment in the laser group on days 3, 7, and 14, then at 1 month followed by every 2 weeks until completion of leveling and alignment. Visual analogue scale questionnaires were completed by each patient over 7 days from initial archwire placement. Digital models were used to monitor changes in the irregularity index. Blinding was applicable for outcome assessors only.

The mean time for leveling and alignment was significantly lower in the laser compared to the control group (68.2 ± 28.7 and 109.5 ± 34.7 days, respectively). The laser group displayed a significantly higher mean alignment improvement percentage as well as lower pain scores compared to the control group.

Within the constraints of the current study, LLLT has a potential for acceleration of anterior segment alignment as well as reduction of the pain associated with placement of initial archwires.

Within the constraints of the current study, LLLT has a potential for acceleration of anterior segment alignment as well as reduction of the pain associated with placement of initial archwires.

To investigate and compare the amount and rate of space closure and tooth tipping during orthodontic space closure toward a recent vs healed first premolar extraction site.

The mandibular arches of 23 patients were included. Treatment plans included lower first premolar extractions. After reaching 0.019 × 0.025-inch stainless-steel archwires (SSAW), patients were subdivided into two groups (Group 1 space closure was carried out toward a healed first premolar extraction space and Group 2 space closure was carried out immediately after first premolar extraction). Elastomeric power chain from second molar to second molar was used to close lower extraction spaces. The following time points were defined T1 just before space closure; T2-T4 1-3 months after initial space closure. Records consisted of dental study models. The amount and rate of extraction space closure were evaluated at each time point.

In Group 1 (healed socket), a total amount of 1.98 mm (coronally) and 1.75 mm (gingivally) of space closure was achieved. The rate of space closure was 0.66 mm/month coronally and 0.58 mm/month gingivally. DLThiorphan In Group 2 (recent socket), the total amount of space closure was 3.02 mm coronally and 2.68 mm gingivally. The rate of space closure was 1.01 mm/month coronally and 0.89 mm/month gingivally. Differences between the two groups were significant (P < .01). Tipping of adjacent teeth during space closure was similar in both groups (P > .05).

In the lower arch, the amount and rate of space closure toward a recent extraction site were higher than that toward a healed extraction socket with similar tipping of teeth in both groups.

In the lower arch, the amount and rate of space closure toward a recent extraction site were higher than that toward a healed extraction socket with similar tipping of teeth in both groups.

The incidence and natural history of large vessel occlusion (LVO) stroke in children is largely unknown. These knowledge gaps limit the uptake of reperfusion therapies and reduce the efficiency of pediatric acute stroke pathways.

To determine the incidence and natural history of pediatric LVO stroke.

This retrospective population-based cohort study was conducted between January 2010 and December 2019, with a mean (SD) follow-up of 37.0 (28.8) months. Admissions from all pediatric hospitals in the state of New South Wales, Australia, with a final diagnosis of arterial ischemic stroke (AIS) in patients 1 month to younger than 17 years were included. A total of 85 of 251 identified cases were excluded based on selection criteria. Data were analyzed from July 2020 to June 2021.

One-third of patients with LVO received mechanical thrombectomy with or without intravenous thrombolysis while the remainder were treated conservatively.

The primary outcome was the pediatric modified Rankin Scale (ped-mRS) score within 6 hours; 35 of 39 [89.7%] within 24 hours).

In this population-based cohort study, the natural history of pediatric patients with LVO stroke treated conservatively was poor, with most experiencing lifelong disability or death. Nearly 90% of pediatric patients with LVO presented within time windows suitable for thrombectomy.

In this population-based cohort study, the natural history of pediatric patients with LVO stroke treated conservatively was poor, with most experiencing lifelong disability or death. Nearly 90% of pediatric patients with LVO presented within time windows suitable for thrombectomy.

Glucagon-like peptide-1 receptor agonists (GLP-1 RAs) have been widely recommended for glucose control and cardiovascular risk reduction in patients with type 2 diabetes, and more recently, for weight loss. However, the associations of GLP-1 RAs with gallbladder or biliary diseases are controversial.

To evaluate the association of GLP-1 RA treatment with gallbladder and biliary diseases and to explore risk factors for these associations.

MEDLINE/PubMed, EMBASE, Web of Science, and Cochrane Library (inception to June 30, 2021), websites of clinical trial registries (July 10, 2021), and reference lists. There were no language restrictions.

Randomized clinical trials (RCTs) comparing the use of GLP-1 RA drugs with placebo or with non-GLP-1 RA drugs in adults.

Two reviewers independently extracted data according to the PRISMA recommendations and assessed the quality of each study with the Cochrane Collaboration risk-of-bias tool. Pooled relative risks (RRs) were calculated using random or fixed-effects models, as appropriate.