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Sedentary lifestyle among school-aged children may cause many health problems in the future. This study was aimed to analyze the determinants of a sedentary lifestyle among school-age children. This was a descriptive-analytical study a with cross-sectional approach. The sample was 130 pairs of school aged-children and their mother/father, involved by using stratified random sampling. The independent variables were family income, household's type, parents' education, child's gender, Body Mass Index (BMI), activity level, parent's occupation, and access to safe housing and playgrounds. The dependent variable was the level of children's sedentary lifestyle. The data was collected by using a questionnaire and analysed by using chi-square dan linear regression. The result showed that there was a significant correlation between mother's education, children's activity level, and access to safe housing and a playground with a sedentary lifestyle (p less then 0.05). School-aged children must be facilitated to be more physically active, and the mother can be involved in this case.The absence of hospitals is one of the problems that arise in health services in remote areas. To get further medical care, patients must be referred outside the island. The purpose of this study was to reveal the situation and experience of patients in emergency treatment in border and coastal areas in North Kalimantan. This study was designed with a qualitative method and a descriptive phenomenological approach was used. It involved 10 participants who lived on Sebatik island with the criteria of having experience with emergency cases and being referred out of the island. Data analysis was performed using a thematic analysis of Braun and Clarke (2006). Three themes emerged from this study inappropriate emergency actions, patients' choice of using the right to be referred, and assistance in challenging referrals. It was revealed that emergency management was not maximal due to the limitations of health workers and service facilities. Patients chose the right to be referred to as an effort to get better health services.Bed bathing procedures taught to nursing students are not appropriately or fully implemented in hospitals by both nurses and nursing students. This signifies the need to review the bed bathing procedures used in schools, by either simplifying or conditioning them according to the practice area. This study is an analytical-descriptive research which aims to analyze ineffective movements in the conventional bed bathing procedure using the left-hand and right-hand map and further improvements of the procedure in order to improve work efficiency. The subjects of this study were six nursing students from the Nursing Study Program of Udayana University. This research was conducted by analyzing video-recorded data containing the procedures performed by the subjects using the left-hand and right-hand map. The mapping was carried out on the six students who had been trained to use the bed bathing procedure. PU-H71 The bed bathing procedure was divided into eight movement elements. This study found that the average time for bathing a patient was 12.17min, excluding the time used for preparation, communication during bathing, tidying up the patient, and evaluation. The effective working time of the left hand was noted to be 6.25min while that of the right hand was 11.40min. The total waiting time on the left hand was 2.87min while that of the right hand was 0.74min. There were 3.26min of left-hand holding of body parts such as the patient's hands and feet, which movement was not found on the right hand. Modification was conducted by eliminating ineffective movements based on the economic principles of movement and the left-hand and right-hand map. It was concluded that after modification the average time for bathing a patient was 5.73min and work efficiency increased by 52.92%. Both hands worked simultaneously and there was no waiting movement.Sleep disorders adversely affect daily activities and cause physiological and psychiatric problems. The shortcomings of benzodiazepine hypnotics have led to the development of ramelteon, a melatonin MT1 and MT2 agonist. Although the sleep-promoting effects of ramelteon have been documented, few studies have precisely investigated the structure of sleep and neural oscillatory activities. In this study, we recorded electrocorticograms in the primary motor cortex, the primary somatosensory cortex and the olfactory bulb as well as electromyograms in unrestrained rats treated with either ramelteon or vehicle. A neural-oscillation-based algorithm was used to classify the behavior of the rats into three vigilance states (e.g., awake, rapid eye movement (REM) sleep, and non-REM (NREM) sleep). Moreover, we investigated the region-, frequency- and state-specific modulation of extracellular oscillations in the ramelteon-treated rats. We demonstrated that in contrast to benzodiazepine treatment, ramelteon treatment promoted NREM sleep and enhanced fast gamma power in the primary motor cortex during NREM sleep, while REM sleep was unaffected. Gamma oscillations locally coordinate neuronal firing, and thus, ramelteon modulates neural oscillations in sleep states in a unique manner and may contribute to off-line information processing during sleep.Ginsenoside Rb1 has been shown to have antidiabetic and anti-inflammatory effects. Its major metabolite, compound K (CK), can stimulate the secretion of glucagon-like peptide-1 (GLP1), a gastrointestinal hormone that plays a vital role in regulating glucose metabolism. However, the mechanism underlying the regulation of GLP1 secretion by compound K has not been fully explored. This study was designed to investigate whether CK ameliorates incretin impairment by regulating the RhoA/ROCKs/YAP signaling pathway and cytoskeleton formation in NCI-H716 cells. Using NCI-H716 cells as a model cell line for GLP1 secretion, we analyzed the effect of CK on the expression of RhoA/ROCK/YAP pathway components. Our results suggest that the effect of CK on GLP1 secretion depends on the anti-inflammatory effect of CK. We also demonstrated that CK can affect the RhoA/ROCK/YAP pathway, which is downstream of transforming growth factor β1 (TGFβ1), by maintaining the capacity of intestinal differentiation. In addition, this effect was mediated by regulating F/G-actin dynamics.

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