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Additionally, the anchorage forces are less sensitive to additional lacerations in the larger Evolut (29 case). The results suggest that a larger self-expending device can ensure stronger anchorage and can lower the risk of possible migration, when TAVR is performed in a lacerated bioprosthesis.Hand injuries are a significant problem in many industries with relatively high incidence rates and injury severity. Many workers are required to wear impact protective gloves to protect their hands from impact-related hazards. This research presents the results of an experimental quantification of metacarpal gloves performance subjected to controlled impacts. Thirteen cadaveric hands were used to conduct a set of controlled impact tests on protected and unprotected hands. The controlled impacts targeted the proximal interphalangeal (PIP) joints, the metacarpophalangeal (MCP) joints, and the middle section of the metacarpal bones. Two types of metacarpal gloves commonly used in mining and oil and gas operations were selected for the tests. These gloves include different material and protection configurations on the dorsal side of the hand. The performance of selected gloves was quantified using the maximum reaction force to the impact and number of bone fractures. A total of 191 impacts produced 108 fractures, from which 71% corresponded to the unprotected hands and 40% to the protected hands. Depending on the impact position and type of glove used, the effect of protection ranged from no change up to a 23% reduction in peak reaction force.Lateral ankle sprains are highly prevalent during sporting activities, as it accounts for approximately 60% of all athletic injuries. There is currently a paucity of research which provides kinetic and kinematic assessments of sprains and giving-way episodes of the ankle joint. The aim of this case study was to examine the kinetics and kinematics of the ankle and knee during a giving-way episode in a female ice hockey player during a 180-degree pivot turn, which was conducted in a 3D motion capture laboratory. Three trials were conducted on this participant (one accident trial, two control trials). Kinetic and kinematic analysis was conducted on the outside leg during a left 180-degree pivot turn (right leg). The plantarflexion angle of the giving-way trial was larger than the control trials from the point of initial contact until the end of the trial. Inversion was also 27-degrees greater 150 ms after initial contact in the giving-way trial and 26-degrees greater compared to control trials 1 and 2. Substantially greater plantarflexion, inversion and internal rotation angles of the ankle were observed during the giving-way trial compared to control trials. ORY-1001 The maximum vertical and horizontal ground reaction forces, as well as ankle inversion and internal rotation moments, were lower for the giving-way trial in comparison to the control trials. Further research is needed to understand the influence of plantarflexion angle with a giving-way episode of the ankle. This study provides valuable kinetic and kinematic information regarding a giving-way episode of the ankle.Community ambulation requires gait adaptations to navigate environmental obstacles. It is well known that while crossing obstacles, variables quantifying the gait pattern are controlled relative to the obstacle's position. However, the stability of these gait variables is underexplored. We measured foot positions relative to an obstacle as young and older adults stepped over it. We report secondary analysis of this data in which we quantified the stability of the step length when the two feet are placed on either side of the obstacle. We employed the uncontrolled manifold approach to test the hypotheses that (1) synergistic across-trial co-variation in the distances of the front and the back heel from the obstacle edge will stabilize the step length, and (2) older adults will display weaker synergies (i.e., lower step length stability). We observed that the front and back heel distances relative to the obstacle's edge co-varied synergistically to stabilize the step length for both age groups. Therefore, foot placement during obstacle navigation is controlled not only with reference to a feature of the environment (i.e. the obstacle), but also to stabilize the step length, presumably to control COM motion. The synergy index was 38% lower for older adults than young adults. This decline may be associated with aging-related functional deficits and tripping-related falls.Subclinical leaflet thrombosis is becoming a major concern in valve-in-valve procedures, whereby a transcatheter aortic valve device is deployed inside a failed bioprosthetic surgical valve. Blood flow stagnation and prolonged residence times in the neo-sinuses have been suggested as possible explanations for leaflet thrombosis. The BASILICA technique, which was originally developed to treat coronary flow obstruction, has also been proposed as an alternative to reduce the risk of thrombus formation. The aim of this study is to understand the impact of BASILICA on the valve-in-valve thrombogenicity using computational fluid dynamics simulations. To this end, two Eulerian and two Lagrangian approaches were employed to estimate near-wall stagnation measures in eight valve-in-valve models. The models included an intact or lacerated Sorin Mitroflow surgical valve, and either a SAPIEN or Evolut transcatheter aortic valve device. The Lagrangian approaches predicted a high number of particles and vortices concentration in the proximal areas of the neo-sinuses, while the Eulerian approaches did so in the distal areas. As a consequence, this study demonstrated that Lagrangian approaches are better predictors of subclinical leaflet thrombosis, since they match experimental and clinical findings. Additionally, the SAPIEN valve possess a higher risk for developing leaflet thrombosis, and two lacerations are shown to provide the best results in terms of development of vortices and accumulation of particles within the neo-sinuses. This study highlights the potential of computational modeling in aiding clinicians in their decision-making in valve-in-valve and BASILICA procedures.