Thomsoncote5073

Objective Media coverage of disorders and medical advancements can impact public perception regarding the riskiness, effectiveness, and accessibility of treatment options. We studied that coverage for epilepsy with a focus on surgical interventions and emerging neurotechnologies. Methods Epilepsy-related English language articles published through 2019 were retrieved from online International news media with a circulation of 80,000 or above. We used directed content analysis of news articles to code content into a priori categories both to identify salient themes and to characterize their valence. Results One hundred forty-six unique articles matched our search terms. Overall, there was a steady increase in epilepsy reporting over time, with a majority of articles published with a positive tone. Neuromodulation was the focus of over 50% of all the articles in the time points analyzed. Vagus nerve stimulation (VNS) and deep-brain stimulation (DBS) were discussed more prominently than other types of neurotechnological interventions; VNS was the neurotechnological focus in 39% of the pediatric articles; resective surgery was the focus in 34% of adult articles. Access, support, and epilepsy literacy were the central themes in the context of ethical, legal, and social issues. Significance News media can influence the trust that the public places in science and medicine, and by extension, influences health policy. As innovations in neurotechnology for epilepsy emerge, understanding of individual and societal values is essential to their beneficial evolution and translation to care.Objective Treatment-emergent adverse events (TEAEs) in clinical trials are typically reported for the full duration of the treatment period including titration and maintenance. Drug-related central nervous system (CNS) TEAEs are common with antiseizure medications (ASMs) and can affect drug tolerability. In this report, we test the hypothesis that drug-related CNS TEAEs have early onset and decrease with time. Unlike prior ASM clinical trials, a novel design was used for brivaracetam (BRV) without initial drug titration allowing assessment of habituation to TEAEs separate from dose titration. Methods Data were pooled from three studies (N01252 [NCT00490035], N01253 [NCT00464269], N01358 [NCT01261325]) in adult patients (≥16 years of age) with focal seizures receiving BRV adjunctive therapy. This post hoc analysis reports data on the prevalence and incidence of all drug-related CNS TEAEs and all TEAEs over time in patients who received BRV doses of 50-200 mg/day (without titration) vs. placebo during a 12-week treatment period. Results A total of 1262 patients received the following placebo (n = 459), BRV 50 mg/day (n = 200), BRV 100 mg/day (n = 353), and BRV 200 mg/day (n = 250). Both the incidence (p less then .0001) and prevalence (p less then .0001) of drug-related CNS TEAEs (all with frequency ≥ 5%) changed across time with peak TEAEs in week 1 then significantly reducing over the first 6 weeks for prevalence and the first 3 weeks for incidence. Conclusions Drug-related CNS TEAEs occurred early and substantially habituated over several weeks. TEAEs of ASMs might be better represented by division into early and late phases to guide clinician monitoring and patient expectations.Background Nondisclosure in cases of child sexual abuse (CSA) can lead to numerous aversive outcomes for children who have been sexually abused, the most serious of which include untreated psychological symptoms and possible further abuse. While victim testimony is often required for perpetrator conviction or disruption of contact, children face multiple barriers to reporting abuse. Research suggests the likelihood of disclosure is impacted by both characteristics of children (i.e., age and gender), as well as abuse characteristics (i.e., relation to perpetrator, severity and frequency of abuse). Objective Although these factors have been studied in relation to rates of disclosure, relatively little is known about their impact on temporal delays in reporting CSA. Participants and setting Special access was obtained to review classified RCMP case files on CSA drawn from the greater Okanagan area, British Columbia, Canada (n = 164). Methods Cases were coded according to victim and abuse characteristics. A multivariate Cox regression analysis was used in order to analyze the impact each variable of interest had on time until a disclosure was made. Results All predictors were found to significantly impact delays of disclosure, x2(6) = 65.558, p = .000. Delays of disclosure were decreased as age of the child increased or if the child was female. Alternatively, if abuse was more severe, occurred at a higher frequency, or if perpetrators were more closely related, delays of disclosure increased. Conclusions The current study provides potential for tailored approaches according to individual characteristics and vulnerabilities in CSA investigations and treatments.Abusive head trauma (AHT) is the leading cause of fatal child physical abuse. Victims may initially present with clinically occult AHT without overt signs of head trauma or with only subtle, nonspecific symptoms, which can make timely recognition of AHT challenging. Research has shown missed opportunities for early detection of AHT in the medical setting are common and can lead to repeated injury. Neuroimaging is needed to diagnose clinically occult AHT but is not without risk. Researchers have worked to understand the yield of neuroimaging in detection of clinically occult AHT and to identify risk factors, yet findings have varied widely across studies. Identifying which children undergoing physical abuse evaluations are at highest risk of clinically occult AHT is key to development of evidence-based imaging decision support tools for clinicians. Here we discuss the recent literature, identify potential reasons for variation across studies, and offer opportunities for future research.In the global context of river fragmentation, predicting fish migration is urgent to implement management actions aimed at protecting and promoting the free movement of diadromous fish. However, large-scale applicability of conservation measures requires transferable models that enable prediction of migration even in data-poor regions. Here, we surveyed 12 contrasted European river sites to predict the activity peaks of silver eels (Anguilla anguilla) during river migration towards spawning areas through an ensemble modelling approach. Site-specific Boosted Regression Tree (BRT) models were adjusted using standardized hydrological variables to predict migration probability, which were aggregated in consensus predictions. Results of independent cross-validations demonstrated that silver eel migration runs were accurately predicted in response to changes in river discharge. read more Transferability and predictive performance were improved by considering catchment-size dissimilarity between river sites (85 to 109,930 km2s that are widely available across European hydrological stations.As the most serious form of soil erosion, gully erosion can be triggered by individual high-intensity rainfall events. In this study, a total of 369 small catchments in 24 sites were sampled to investigate the relationship between rainfall and gully erosion on hillslopes and to study the impacts of vegetation restoration following heavy rainstorms in the central Loess Plateau, China. A total of 280 newly formed gullies on hillslopes were identified by comparing pre-storm Google Earth images and post-storm unmanned aerial vehicle (UAV) images. The results showed that the dimensions and density of gullies increased significantly with rainfall gradient increasing from the periphery to the storm center. When the rainfall amount exceeded 200 mm, gully volumetric density reached up to 928.39 m3/km2 and the mean gully volume was 15.74 m3, 12.8 times and 2.3 times the mean gully volume for rainfall amounts of 106 and 150 mm, respectively. In the sampled small catchments, where cropland was dominant, the relationships between the gully densities and rainfall amount could be fitted with exponential functions. Vegetation restoration was found to reduce the densities and dimensions of gullies on hillslopes. Compared to those in cropland-dominated catchments, the density of gullies in grassland-dominated catchments was found to be lower by >60%, while the individual gully volume was found to be 1.6 times higher. In small catchments, no new hillslope gullies were observed when the rainfall amount fell below 106.7 mm. Therefore, the rainfall thresholds for (1) ephemeral-gully initiation on grassland hillslopes, (2) permanent-gully initiation, and (3) permanent-gully initiation on cropland hillslopes are concluded to be not >106.7 mm, not >136.1 mm, and not >110.2 mm, respectively. This suggests that the restoration of cropland to grassland would reduce the rainfall threshold for gully initiation.In aquatic ecosystems, water microbial communities can trigger the outbreak or decline of cyanobacterial blooms. However, the microbiological drivers of Microcystis decomposition in reservoirs remain unclear. Here, we explored the bacterial community metabolic profile and co-occurrence dynamics during Microcystis decomposition. The results showed that the decomposition of Microcystis greatly altered the metabolic characteristics and composition of the water bacterial community. Significant variations in bacterial community composition were observed the bacterial community was mainly dominated by Proteobacteria, Actinobacteria, Planctomycetes, and Bacteroidetes during Microcystis decomposition. Additionally, members of Exiguobacterium, Rhodobacter, and Stenotrophomonas significantly increased during the terminal stages. Dissolved organic matters (DOM) primarily composed of fulvic-like, humic acid-like, and tryptophan-like components, which varied distinctly during Microcystis decomposition. Additionally, the metabolic activity of the bacterial community showed a continuous decrease during Microcystis decomposition. Functional prediction showed a sharp increase in the cell communication and sensory systems of the bacterial communities from day 12 to day 22. Co-occurrence networks showed that bacteria responded significantly to variations in the dynamics of Microcystis decomposition through close interactions between each other. Redundancy analysis (RDA) indicated that Chlorophyll a, nitrate nitrogen (NO3--N), dissolved oxygen (DO), and dissolved organic carbon (DOC) were crucial drivers for shaping the bacterial community structure. Taken together, these findings highlight the dynamics of the water bacterial community during Microcystis decomposition from the perspective of metabolism and community composition, however, further studies are needed to understand the algal degradation process associated with bacteria.A 3D pretreated peanut shell-supported graphene oxide (PPS/GO) aerogel has been facilely prepared through a brief sonication + freeze-shaping technique, avoiding the traditional application of hydrothermal method which suffered from high temperature and long reaction time as well as significant loss of oxygen-containing functional groups. It was then employed to efficient norfloxacin (NOR) removal from aqueous medium. The mechanism of sonication time on the structure and adsorption properties of as-obtained PPS/GO aerogels was emphatically discussed via combining instrumental analyses, batch adsorption experiments and density functional theory (DFT) calculations. Results showed that the 3D PPS/GO aerogel with a decrease in oxygen functional groups and an increase in sp2-derived sp3 hybridization regions was observed as sonication time provided in excess, causing the worse removal efficiency towards NOR. The resulting PPS/GO(51) aerogel obtained at sonication of 2 min and GO loading content of 200 mg/(PPS)g exhibited the optimal NOR adsorption capacity (pH 6.