Sheltonovesen3125

Hibiscus species are rich in phenolic compounds and have been traditionally used for improving human health through their bioactive activities. The present study investigated the phenolic compounds of leaf extracts from 18 different H. acetosella accessions and evaluated their biofunctional properties, focusing on antioxidant and antibacterial activity. The most abundant phenolic compound in H. acetosella was caffeic acid, with levels ranging from 14.95 to 42.93 mg/100 g. The antioxidant activity measured by the ABTS assay allowed the accessions to be classified into two groups a high activity group with red leaf varieties (74.71-84.02%) and a relatively low activity group with green leaf varieties (57.47-65.94%). The antioxidant activity was significantly correlated with TAC (0.933), Dp3-Sam (0.932), Dp3-Glu (0.924), and Cy3-Sam (0.913) contents (p less then 0.001). The H. acetosella phenolic extracts exhibited antibacterial activity against two bacteria, with zones of inhibition between 12.00 and 13.67 mm (Staphylococcus aureus), and 10.67 and 13.33 mm (Pseudomonas aeruginosa). All accessions exhibited a basal antibacterial activity level (12 mm) against the Gram-positive S. aureus, with PI500758 and PI500764 exhibiting increased antibacterial activity (13.67 mm), but they exhibited a more dynamic antibacterial activity level against the Gram-negative P. aeruginosa.Silicone rubbers (SIRs) are common industrial materials which are often used for electrical insulation including weather sheds on non-ceramic insulators (NCIs). While SIRs are typically resilient to outside environments, aging can damage SIRs' favorable properties such as hydrophobicity and electrical resistance. Detecting SIR aging and damage, however, can be difficult, especially in service. In this study we used hyperspectral imaging (HSI) and previously investigated aging methods as a proof of concept to show how HSI may be used to detect various types of aging damage in different SIR materials. The spectral signature changes in four different SIRs subjected to four different in-service aging environments all occurred between 400--650 nm. Therefore, remote sensing of NCIs using HSI could concentrate on bands below 700 nm to successfully detect in service SIR damage.Alterations in DNA repair pathways are one of the main drivers of cancer insurgence. Nevertheless, cancer cells are more susceptible to DNA damage than normal cells and they rely on specific functional repair pathways to survive. Thanks to advances in genome sequencing, we now have a better idea of which genes are mutated in specific cancers and this prompted the development of inhibitors targeting DNA repair players involved in pathways essential for cancer cells survival. Currently, the pivotal concept is that combining the inhibition of mechanisms on which cancer cells viability depends is the most promising way to treat tumorigenesis. Endoxifen mouse Numerous inhibitors have been developed and for many of them, efficacy has been demonstrated either alone or in combination with chemo or radiotherapy. In this review, we will analyze the principal pathways involved in cell cycle checkpoint and DNA repair focusing on how their alterations could predispose to cancer, then we will explore the inhibitors developed or in development specifically targeting different proteins involved in each pathway, underscoring the rationale behind their usage and how their combination and/or exploitation as adjuvants to classic therapies could help in patients clinical outcome.To study the dynamic mechanical characteristics and constitutive relation of concrete materials under freeze-thaw (FT) cycle conditions, C35 concrete was taken as the research object in this paper, and FT tests were carried out with a freeze-thaw range of -20-20 °C and a freeze-thaw frequency up to 50 times. By using the separated Hopkinson pressure bar (SHPB) system, impact compression tests of concrete specimens under different FT cycle actions were developed, then the dynamic fracture morphology, fracture block distribution, stress-strain curve, peak stress and other dynamic mechanical properties of concrete were analyzed, and the influence law of FT action and strain rate was obtained. Through introducing the freeze-thaw deterioration damage factor and the stress damage variable, the dynamic visco-elastic damage constitutive equation of freeze-thawed concrete was constructed based on component combination theory. Furthermore, the damage evolution process and mechanism of freeze-thawed concrete materials were revealed. The research results show that the dynamic mechanical properties of concrete under a freeze-thaw environment are the combined results of the freeze-thaw deterioration effect and the strain rate strengthening effect. The dynamic visco-elastic damage constitutive model established in this paper can effectively describe the dynamic mechanical properties of freeze-thawed concrete, and has the characteristics of few parameters and good effect. The stress damage evolution path of concrete goes backward with the increase of FT cycles and the development speed gradually slows down. The greater the difference in FT cycles, the greater the difference in stress damage path.Non-target screening (NTS) based on the combination of liquid chromatography coupled to high-resolution mass spectrometry has become the key method to identify organic micro-pollutants (OMPs) in water samples. However, a large number of compounds remains unidentified with current NTS approaches due to poor quality fragmentation spectra generated by suboptimal fragmentation methods. Here, the potential of the alternative fragmentation technique ultraviolet photodissociation (UVPD) to improve identification of OMPs in water samples was investigated. A diverse set of water-relevant OMPs was selected based on k-means clustering and unsupervised artificial neural networks. The selected OMPs were analyzed using an Orbitrap Fusion Lumos equipped with UVPD. Therewith, information-rich MS2 fragmentation spectra of compounds that fragment poorly with higher-energy collisional dissociation (HCD) could be attained. Development of an R-based data analysis workflow and user interface facilitated the characterization and comparison of HCD and UVPD fragmentation patterns.