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This study investigates the underlying physiological mechanisms that may lead to improved outcomes for symptomatic convergence insufficiency (Cl) patients after 12 weeks of office-based vergence/accommodation therapy (OBVAT) by evaluating the change in the main sequence of vergence and saccadic eye movements. In this prospective trial, 12 participants with symptomatic Cl were recruited and treated with 12 weeks of OBVAT. Outcome measures included the objective assessment of the following peak velocity, time to peak velocity, latency, response amplitude, and clinical changes in the near point of convergence (NPC), positive fusional vergence (PFV) and symptoms via the Convergence Insufficiency Symptom Survey (CISS). Ten of the twelve participants (83%) were categorized as "successful" and two were "improved" based on pre-determined published criteria (CISS, NPC, PFV). There were statistically significant changes in peak velocity, time to peak velocity, and response amplitude for both 4° and 6° symmetrical convergence and divergence eye movements. Paclitaxel order There was a significant change in the main sequence ratio for convergence post-OBVAT compared to baseline measurements (P=0.007) but not for divergence or saccadic responses. Phasic/step vergence movements adjust the underlying neural control of convergence and are critical within a vision therapy program for Cl patients.The management of Amelogenesis imperfecta often poses a challenge for the dentists. It not only includes aesthetic and functional rehabilitation of the patient, but also requires a positive rapport building with the patient due to psychosocial issues. The treatment plan is driven by patient demands, age, cost-affordability, severity of the disease and the presenting condition. The present case report elucidates step by step management of a 20 year-old female who presented with generalized hypersensitivity, intermittent pain associated with multiple decayed posterior teeth, poor dental aesthetics and anterior deep bite. The management consisted of endodontic treatments in all teeth, crown lengthening to gain ferrule in some teeth, provision of provisional bridges at an increased vertical dimension for six weeks followed by full mouth all ceramic crowns on all teeth. The prosthetic management aimed at reorganized occlusal scheme. There was a significant improvement in the aesthetics, deep bite, and along with correction of the vertical dimension of occlusion. Key wordsAmelogenesis imperfecta, hypoplastic enamel, mouth rehabilitation, dental esthetics. Copyright © 2020 Medicina Oral S.L.Background Many systematic reviews and meta-analysis have indicated beneficial effects of adjunctive systemic antibiotics in periodontal therapy in specific situations. However, some essential issues such as the ideal time of their administration during periodontal therapy remain unanswered. This systematic review aimed to determine at which phase of periodontal treatment would adjunctive systemic antibiotics lead to the best clinical outcomes, during the active phase or in the reevaluation phase. Material and Methods Searches in the databases Medline, Scopus and Cochrane Library were conducted. The randomized clinical trials and retrospective cohort studies comparing the clinical benefits of adjunctive systemic antibiotic administration in the active phase of periodontal treatment versus their administration in the reevaluation phase were included. The primary outcomes assessed were differences in clinical changes in periodontal pocket depth and clinical attachment loss at all post-treatment phases. Results uation, systemic antibiotics, timing. Copyright © 2020 Medicina Oral S.L.Background This study was designed to quantitatively compare the presence of apatite peaks on demineralized dentin to induced bio-mimetically by bioactive commercial materials. Material and Methods Dentin slice specimens (n=6) were prepared and demineralized by by17% EDTA for 2 hours. Each disks materials (Theracal, Biodentine, CPP-ACP) were freshly prepared and was maintained in close contact with a demineralized dentin specimen immersed in PBS solution during one week. To evaluation of bioactivity, cements disks (n=6) were prepared from each material and immersed in PBS solution for one week. The bioactivity and remineralization ability was evaluated using FTIR spectroscopy and Scanning Electron Microscopy. The Ca/P ratio of the surface of dentin and cements disks were compared with one -way ANOVA, independent T test and Duncan test (α=0.05). Results Ca/P weight ratio of Biodentine (187.5) was significantly higher than Theracal (10.10) and Theracal higher than CPP-ACP (0.37) (P=0.008). Demineralized dentin in contact with Test materials, indicated Ca and P peak after 7 days, but not showed statistically differences between the groups (P=0.08). Conclusions The outcome revealed that bioactive cements and CPP-ACP had bioactivity capability during one week. Biodentine had higher bioactivity between others. Demineralized dentin could be remineralized with bioactive materials. Key wordsBioactive, cements, fourier transform infrared spectroscopy, scanning electron microscopy, tooth remineralization. Copyright © 2020 Medicina Oral S.L.Background Bisphosphonates (BP) are synthetic pyrophosphate-like substances with antiresorptive properties and specifically affect osteoclastic activity. In 2007, the American Association of Oral and Maxillofacial Surgeons (AAOMS) defined diagnostic criteria for Osteonecrosis of the Jaws Associated with Bisphosponates (BRONJ). BRONJ is mainly diagnosed by clinical features, but the detection of early bone changes by imaging may help prevent and better understand the disease. The objective of this study was to evaluate maxillary changes in CBCT in patients using BP. Material and Methods All included patients were diagnosed with osteonecrosis and received bisphosphonate drugs in the last ten years. All imaging examinations were obtained by I-CAT and 3D Accuitomo. The multiplanar reconstructions were analyzed by an examiner without knowledge of the clinical aspects and location of the lesions. Results The study sample consisted of 21 patients, the majority of the sample represented patients with cancer (76.2%), the other patients had osteoporosis (23.

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