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Generalized parodontal diseases (GPD) consistently occupy one of the leading places in the structure of dental diseases. Early diagnosis of the initial degree of generalized parodontitis (GP) is an effective way of secondary prevention. This is due to the complexity of understanding the etio-pathogenetic mechanisms of the development generalized parodontal diseases (GPD) and the high association of them with a number of diseases of the internal organs and systems with common points of contact between interdependence and mutual influence, in particular with anorexia nervosa (AN). The aim of this research was to develop a protocol for the treatment of GP in patients with AN. The object - 60 patients (mean age 26±3.8 years), with a diagnosis of GP, I-II degree, chronic, and AN, restrictive, which by simple randomization were divided into three groups (randomized by sex, age of patients, underlying and comorbidy diagnosis) to study the clinical effectiveness of our proposed method. Clinical, radiological, hygienic, immunological, biochemical, psychological and statistical methods were used. Conclusions. Thus, as a result of the proposed treatment protocol, the largest number of satisfactory treatment results was observed in group III patients (85.0±8.0%) with the inclusion of drugs that affect the pathogenetic mechanisms of the disease, including normalization of local immunity, markers of decline oxidative-antioxidant stress, radiological data of normalization of bone tissue of the alveolar process, a tendency to reduce microbial and tissue sensitization.The goal of the study is assessing the population structure of lymphocytes and the subpopulation composition of NK cells in the peripheral blood of humans in the case of drug-induced osteonecrosis of the jaw for improving the quality of diagnosis, treatment, and prevention of osteonecrosis of the jaw. Thirty patients were examined, including 15 patients with drug-induced osteonecrosis of the jaw (ONJ), 10 healthy individuals, and five patients with pyoinflammatory diseases of the maxillofacial region, aged 49 to 77. Every four weeks, the patients had been receiving 4 mg intravenous injections of bisphosphonates (the Zometa preparation (zoledronic acid)) for 1.5 - 3 years. The study was performed on a FACS Canto II flow cytometer manufactured by Becton Dickinson (BD), USA. In the patients with ONJ, an imbalance of the NK cell subtypes was observed. As to the common NK cells, the level of subtypes of cytolytic NK cells (CD3-CD16+(or hight)56dim) was elevated, and the level of cytokine-producing cells (СD3-CD16-(or low) 56bright) was reduced, compared to the healthy individuals (p less then 0.05). In the patients with ONJ, after the surgical treatment, the relative and absolute levels of lymphocytes and the total level of NK cells (CD3-CD16+/56+) normalized on the seventh day. The level of NK cells subtypes did not change after the treatment. This pathology is characterized by a low level of innate protection factors, as evidenced by the reduction of the total population of NK cells, and the imbalance of NK cells subtypes. The imbalance of NK cells (the natural killer cells) was an indicator of unfavorable prognosis for osteonecrosis treatment.The purpose of the study was to evaluate the functional resistance of enamel in children with malocclusions. Material and research methods there were examined 579 children aged 12-16 years with malocclusions and was determined the functional enamel resistance. The data obtained in the study indicate that the prevalence of malocclusions among examined children, according to the average data, is 67,76±1,99%. There is a tendency to decrease the number of persons with orthodontic pathology with the age among the examined group of children. It was found that from 12 to 16 years the prevalence of malocclusions decreases from 71,5±4,47% to 64,17±4,38%, р>0,05. The lowest prevalence of malocclusions is found in the group of 16-year-old children. From 12 to 13 years the prevalence of malocclusions decreases by 3,43%, from 13 to 14 years - by 2,49%, from 14 to 15 years increases by 0,72%, and by 16 years decreases by 5,38%. The decrease in the prevalence of malocclusions in the group of examined children with age is exlts of the study showed that in children with CR enamel, malocclusions are much more common than in chidren with RR and CS enamel. In children with CS enamel, the enamel structure is resolved, which can be caused by a violation of the mineral metabolism, especially during the period of development and formation of the body. Against the background of such disorders, there may be susceptibility to the development of dental caries and malocclusions, which is important to consider when carrying out preventive measures.The frequency of occurrence of inverted papilloma (IP) ranges from 0.4% to 7% of all neoplasms of the nasal cavity and paranasal sinuses. Inverted papilloma is a benign epithelial tumor that refers to Schneider's sinonasal papilloma. IP is usually diagnosed in the late stages in average, 1-4 years after the first appearance of sinonasal symptoms. The purpose of this study - to summarize the results of diagnosis and treatment of patients with sinonasal inverted papilloma, who underwent surgical treatment in our department. We evaluated 37 patients with histologically verified sinonasal IP from 2015 to 2019. 29 were men (78,4%), and 8 women (21,6%). Along with generally accepted clinical studies, all patients underwent CT and MRI of the paranasal sinuses. Using the results of CT and MRI images, all patients were classified according to the Krouse classification. We evaluated the postoperative period, the presence of complications. The main criteria for assessing the results of treatment were indicators of contist common was diagnosed at T2-T3 stages and found in the maxillary and ethmoid sinus. Recurrence of IP was diagnosed in 7 (18.9%) patients, with an average recurrent rate in 14 months. Surgical treatment with removal area of hyperostosis and laser destruction surrounding tissues is the method of choice.The aim of the study was to determine the correlation between implanted IOL material type to detect CME after NSAID use in cataract surgery. Compound 3 concentration Study involved 94 eyes of 72 patients. Eyes were equally divided into two groups (n-47 in each). Post-operatively treatment regimen for participants from Group I included antibiotic and NSAID eye drops, while participants from group II were treated only with antibiotic eye drops. Acrylic hydrophobic intraocular lens (IOL) was implanted in all patients comprising both groups. No patient developed cystoid macular edema from either group (CME). In both groups (with or without NSAID eye drops cover) mean central retinal thickness (CRT) was 230±0.005 microns before the surgery. No statistically significant changes of CRT was noted in both groups (5± 0.09 microns ) (p less then 0.5). Study analysis has shown, that cystoid macular edema has not developed in patients, who underwent uncomplicated cataract surgery with hydrophobic IOL implantation, with or without NSAID eye drop cover.

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