Schaeferravn2461

These results suggest that the single-egg is not only a reduction of reproductive output per clutch, but it may provide negative effect on ontogeny.

To evaluate cardiovascular safety of two new inhaled fixed-dose combinations for treatment of asthma (i) the inhaled corticosteroid/long-acting beta2-agonist (ICS/LABA) mometasone furoate/indacaterol acetate (MF/IND), (ii) the ICS/LABA/long-acting muscarinic antagonist (LAMA) MF/IND/glycopyrronium bromide (GLY).

Patient-level data were pooled from four randomized trials, including 52-week studies PALLADIUM (n=2216) and IRIDIUM (n=3092), 24-week study ARGON (n=1426), and 12-week study QUARTZ (n=802). Cardio-/cerebrovascular (CCV) event frequencies were examined in the following comparisons (1) LABA effect pooled-dose MF/IND vs. pooled-dose MF; (2) LAMA effect pooled-dose MF/IND/GLY vs. pooled-dose MF/IND; (3) ICS-dose effects (a) high-dose MF/IND vs. medium-dose MF/IND, (b) high-dose MF/IND/GLY vs. medium-dose MF/IND/GLY; (4) intra-class effects (a) high-dose MF/IND vs. Fluticasone/Salmeterol (F/S), (b) high-dose MF/IND/GLY vs. F/S+Tiotropium (TIO). Risk estimates (percentage of patients with ≥1 CCV event) cardiovascular risk attributable to the addition of IND to MF or addition of GLY to MF/IND. Similarly, no evidence of increased cardiovascular risk was observed with an increase in the ICS-dose or relative to F/S ± TIO.

Reducing the frequency of long-acting injectable antipsychotic medication may reduce carer burden.

To evaluate the impact of reduced frequency of long-acting injectable antipsychotic medication on carer burden in stable patients with schizophrenia.

Carer burden was assessed using the Involvement Evaluation Questionnaire (IEQ) within a 52-week, prospective, single-arm, non-randomised, open-label, international, multicentre study evaluating the impact of transitioning stable patients with schizophrenia to paliperidone palmitate 3-monthly (PP3M) from paliperidone palmitate 1-monthly (PP1M).

159 carers completed the IEQ (mean [standard deviation, SD] age 54.8 [12.8] years); 52.2% were the patients' parent and>50% had >32h/week of patient contact. At baseline, mean [SD] IEQ total score was in the lower range (23.8 [12.6]), reflecting patient stabilisation. At last observation carried forward (LOCF) endpoint, the IEQ total score decreased by a mean (95% CI) of -4.0 (-5.9, -2.1), indicating a significant overall reduction in carer burden (P<0.0001). The six IEQ items with the highest carer burden at baseline were within the urging and worrying domains, in which burden was significantly improved at LOCF endpoint (P<0.0001). Exploratory analyses found that higher carer burden was associated with lower functional remission (Personal and Social Performance score>70) at baseline and LOCF endpoint, and with the patient being part of the carer's household. Shorter disease duration correlated with better general health of carers at LOCF endpoint.

Reducing the frequency of antipsychotic medication administration in stable patients with schizophrenia by switching from PP1M to PP3M may reduce carer burden.

Reducing the frequency of antipsychotic medication administration in stable patients with schizophrenia by switching from PP1M to PP3M may reduce carer burden.Cervical lymph nodes are a common site of metastases for malignant tumors, most commonly developed from head and neck primary tumors. But, they can also be secondary to distant primary tumors. We report the case of two patients treated in our Otorhinolaryngology and Head and Neck department for chronic supraclavicular lymphadenopathies, for whom further investigations showed lymph node metastasis originating from distant tumors. Thus, careful clinical examination, imaging tools, and if possible pathological analysis are necessary to establish an early diagnosis for adequate treatment.

The World Health Organization estimates that 422 million people have diabetes, three-quarters of whom live in low- and middle-income countries. Entospletinib purchase Global action plans to address non-communicable diseases (NCDs) recognise the centrality of community engagement to create an enabling environment within which to address risk factors.

In this article, we describe and critically reflect on a cocreated community engagement approach to address type 2 diabetes in the southern plains of Nepal. We coproduced the engagement approach with 40 artists from the Janakpur Women's Development Centre to create an environment for dialogue about diabetes and NCD risk between artists and the general public.

We used participatory action research to produce contextually relevant interactive methods and materials. Methods included artists' peer research to inform creative workshops, a drama performed in 19 villages and a two-day funfair in a public park. We used qualitative and participatory methods to analyse the effect of this en.

Innovative, asset-based community engagement about diabetes and other NCDs at scale is possible through locating, building on and strengthening community resources to address local health issues. Engagement could be enhanced by considering the gendered nature of community engagement spaces and by increasing opportunities for interaction between artists and the general public through more intimate and large-scale events.Hyperkalemia is a frequent complication among kidney transplant recipients that can lead to fatal arrhythmias. The causes of hyperkalemia post kidney transplant are multifactorial and often are drug-induced, and include decreased glomerular filtration rate, tubular dysfunction, and impaired sodium delivery in the distal nephron. This review will discuss pathophysiology and recent updates in the management of both acute and chronic hyperkalemia with a focus on kidney transplant recipients.

Recantation after child sexual abuse (CSA) disclosure refers to the complete denial of prior reports by a victim. In substantiated cases of CSA, recantation has negative effects on criminal proceedings and the protection of current and future victims. Past studies have identified the socio-family factors and CSA characteristics that are associated with recantation. However, the systematization of these risk factors remains limited.

This study aimed to identify the predictors of recantation using a sample of criminal cases of CSA.

The sample consisted of 108 criminal cases of CSA with (n = 46) and without recantation (n = 62). All the cases had been judged in a Brazilian court of law between 2010 and 2016.

The final logistic regression model consisted of the following five significant predictors of recantation a lack of support from the caregiver (odds ratio [OR] = 15.90, p < .001), disclosure to a single individual (OR = 13.75, p = .001), parental offending (OR = 12.44, p = .001), a long time interval (i.