Sanderladegaard8701

spital pediatric urology clinic.

Patients suffering from fibromyalgia syndrome (FMS) are heterogenous. They often present with sensory abnormalities and comorbidities.

We aimed to answer the following questions (1) Is there a specific somatosensory profile in our patient cohort? (2) Can we detect subgroups characterized by a specific combination of sensory and psychological features? and (3) Do psychological parameters influence sensory signs?

In 87 patients with FMS quantitative sensory testing was performed on the hand and evaluated in combination with questionnaire results regarding pain, psychological comorbidities, sleep, and functionality.

Patients presented different somatosensory patterns, but no specific subgroups regarding sensory signs and psychological features were detected. Hypersensitivity for noxious mechanical and thermal stimuli and hyposensitivity for nonnoxious mechanical stimuli were the most prominent features. Thirty-one percent of patients showed signs of central sensitization as indicated by abnormally increae detected in about one-third of patients and associated with higher pain intensities. This supports the notion of central sensitization being a major pathophysiological mechanism in FMS, whereas small-fiber loss may be less important.Post-traumatic stress disorder (PTSD) is a highly prevalent disorder and a highly debilitating condition. Although anhedonia is an important construct of the disorder, the relationship between PTSD and reward functioning is still under-researched. To date, the majority of research on PTSD has focused on fear fear learning, maintenance, and extinction. Here we review the relevant literature-including clinical observations, self-report data, neuroimaging research, and animal studies-in order to examine the potential effects of post-traumatic stress disorder on the reward system. Our current lack of sufficient insight into how trauma affects the reward system is one possible hindrance to clinical progress. The current review highlights the need for further investigation into the complex relationship between exposure to trauma and the reward system to further our understandings of the ethology of PTSD.We described a silver(I)-mediated intramolecular oxidative C-H amination that enables the construction of assorted 1H-indazoles that are widely applicable in medicinal chemistry. The developed amination was found to be efficient for the synthesis of a variety of 3-substituted indazoles that are otherwise difficult to be synthesized by other means of C-H aminations. Preliminary mechanistic studies suggested that the current amination proceeds via single electron transfer (SET) mediated by Ag(I) oxidant.Organophosphorous compounds are still widely used as potential scale inhibitors in the upstream oil and gas industry, particularly in squeeze treatments as they have good adsorption properties on rock and are easily detectable. VX-478 chemical structure However, most phosphonate-based scale inhibitors have some drawbacks, such as poor biodegradability and various incompatibilities with the production system. The low toxicity of bisphosphonates motivated us to test a series of aliphatic and aromatic hydroxybisphosphonates as new oilfield scale inhibitors for calcium carbonate (calcite) and barium sulfate (barite) scales. Thus, the well-known bone-targeting drugs 3-amino-1-hydroxypropane-1,1-bisphosphonic acid (pamidronic acid, SI-1), 4-amino-1-hydroxybutane-1,1-bisphosphonic acid (alendronic acid, SI-2), 5-amino-1-hydroxypentane-1,1-bisphosphonic acid (SI-3), and hydroxyphenylmethylene-1,1-bisphosphonic acid (fenidronic acid, SI-6) are studied along with novel, specially designed bisphosphonates (1,4-dihydroxybutane-1,1,4,4-tetrayl)tetrakisphosphonic acid (SI-4), (1,6-dihydroxyhexane-1,1,6,6-tetrayl)tetrakisphosphonic acid (SI-5), and ((4- aminophenyl)(hydroxy)methylene)bisphosphonic acid (SI-7) in a dynamic tube-blocking scale rig at 100 °C and 80 bar according to typical North Sea conditions. The scale inhibition performance of the new SIs was compared to that of the commercial 1-hydroxyethylidene bisphosphonic acid (HEDP) and aminotrismethylenephosphonic acid (ATMP). The results indicate that all synthesized hydroxybisphosphonates provide reasonable inhibition performance against calcite scaling and show good thermal stability at 130 °C for 7 days under anaerobic conditions.Controlling crystallization is a long-standing issue both from a fundamental and an applied perspective. In particular, our understanding of the influence of confinement on crystallization is far from complete. In this work, we utilize the confined interlayer spaces of hexagonal boron nitride (h-BN), which is one of the typical two-dimensional layered materials with atomically flat BN sheets, not only to prepare h-BN/H2SO4 intercalation compounds but also to initiate crystallization via the acid/base reaction between the intercalant (H2SO4) and gaseous ammonia. We report that the present acid/base reaction leads to the formation of highly oriented ammonium sulfate crystals along specific crystallographic directions. This oriented crystal growth originates from the 2D crystal nucleated in the confined interlayer spaces of h-BN.N-doped porous carbon-based catalysts hold great promise for hydrogen evolution reaction (HER) due to their plentiful cavity construction, high specific surface area, and flexible metal assemblies. Nevertheless, the cumbersome synthetic process and the use of highly corrosive chemicals greatly increase the production costs and pollutions. Herein, we report a facile and eco-friendly thermal puffing strategy, which imitates the popcorn forming process, for the fabrication of N-doped hierarchical porous carbon-CoO x catalysts. The results indicate that the well-developed porosity and high specific surface area (696 m2 g-1) of CoO x -NC-1.0 are achieved during the thermal expansion. Impressively, the as-prepared CoO x -NC-1.0 with ultralow Co loading (0.67 wt %) presents admirable HER performance to drive 10 mA cm-2 at an overpotential of 189 mV in the alkaline electrolyte. Especially, the activity of CoO x -NC-1.0 can be maintained for a continuous ∼70 h test. Such an excellent property of CoO x -NC not only derives from the hierarchical porous structure but is also due to the higher ratio of graphitic-N and pyridinic-N, which promotes the better electrical conductivity and formation of more active Co0 for HER, respectively.