Roymcgrath0442

This study provides insight into the extent to which public commitment to reduce teenage pregnancy made by the President of Sierra Leone made the issue a political priority and the factors that facilitated and hindered this. Using historical observations from government and civil society actors who were involved in the formulation and implementation of the country's National Strategy for the Reduction of Teenage Pregnancy (NSRTP), the study presents lessons learnt, with a particular focus on advocacy. It does not examine the extent to which the NSRTP was operationalised and its objectives fulfilled. Findings indicate that the availability of locally relevant data as well as advocacy from international and national NGOs were factors that led to the President's commitment and the development of a national strategy. Whilst continued verbal support from political leaders and administrative mechanisms for implementation assured that teenage pregnancy reduction stayed on the political agenda, the scarcity of resources as well as the necessary diversion of efforts and resources to the Ebola epidemic impeded implementation. Overall, the findings demonstrate that public commitments made by political leaders - starting with President Ernest Bai Koroma's public declaration in 2012 - kick-started efforts to reduce teenage pregnancy in Sierra Leone; and that despite inadequate human and financial resources for the implementation of the NSRTP, actions taken by both the government and partners over time have contributed to tangible progress.Perceiving one's self as accepted by important others, such as parents, is fundamental and crucial for the well-being of each individual. One major aspect of interpersonal acceptance-rejection theory (IPARTheory) is examining how parental acceptance-rejection affects people's psychological adjustment. This theory has been validated in many countries and cultural groups around the world, but has not been utilized in the Vietnamese context. This research aims to assess the reliability of IPARTheory measures in Vietnam and applicability of the theory itself among a Vietnamese sample. Participants included 162 students from a high school in Hanoi (Mage = 15.58 years; 69.8% female). zeomycin Materials consisted of Vietnamese versions of various IPARTheory measures Parental Acceptance-Rejection Questionnaire, Personality Assessment Questionnaire, Interpersonal Relationship Anxiety Questionnaire, and a demographics form designed specifically for this research. Analyses show that psychological maladjustment significantly correlated with perceived paternal rejection, maternal rejection, and their subscales. Cronbach's alphas were strong, ranging from .73 to .97, except for the dependency subscale and hostility subscale of the Personality Assessment Questionnaire. Thus, the results provide evidence for the reliability of various IPARTheory measures in Vietnam. The relationships found in this study have implications for parents, teachers, and psychologists to employ in order to provide adolescents with appropriate guidance and intervention based on the importance of perceived parental acceptance-rejection.

Persistent and intractable hiccups have a major impact on quality of life and can be a barrier to stroke rehabilitation. The first-line treatment for intractable hiccups, chlorpromazine, can have sedating effects, which may negatively affect rehabilitation participation. Gabapentin has been reported in several cases to be effective in hiccup treatment in both the general and post-stroke populations.

To describe the use of gabapentin for treatment of persistent or intractable hiccups in post-stroke patients.

Four cases were identified by clinicians for a retrospective review. A literature review was concurrently conducted.

This case series presents four patients with improvement or resolution of intractable hiccups on gabapentin in a stroke rehabilitation setting. Therapeutic dose ranged from 100 mg TID to 400 mg BID. Treatment duration ranged from 2days to 5.5weeks. Adjuncts were used in three of the cases. A potential side effect was worsened confusion in one case.

Evidence on the use of gabapentin for persistent or intractable hiccups is limited. This case series expands on the current literature by examining and comparing the current literature to our cases and exploring issues related to dosing, titration, side effects, and adjuncts to gabapentin.

Evidence on the use of gabapentin for persistent or intractable hiccups is limited. This case series expands on the current literature by examining and comparing the current literature to our cases and exploring issues related to dosing, titration, side effects, and adjuncts to gabapentin.In this article, a stochastic SACR hepatitis B epidemic model is taken to be under consideration. We develop a stochastic epidemic model by considering the effect of environmental fluctuation on the hepatitis B dynamics and distribute the transmission rate by white noise. Using the stochastic Lyapunov function theory, we have shown the existence and uniqueness of the global positive solution. The extinction and persistence for our proposed model are derived with sufficient conditions. The numerical simulations are carried out using first-order Itô-Taylor stochastic scheme in the last section for the verification of our theoretical results.

The 2013-2016 Ebola epidemic in West Africa is the worst ever caused by

with over 28,000 human cases and 11,325 deaths. The World Health Organisation (WHO) declared the epidemic a public health crisis that required accelerated development of novel interventions including vaccines. The Medical Research Council/Uganda Virus Research Institute and London School of Hygiene and Tropical Medicine Uganda Research Unit (MRC/UVRI & LSHTM Uganda Research Unit) was among the African research sites that implemented the VAC52150EBL1004 Ebola vaccine trial.

We report on the strategies utilised by the Unit and sponsor in ensuring expedited clinical trial approval and accelerated conduct.

Janssen Vaccines and Prevention B.V. conducted a phase 1 trial to evaluate the safety, tolerability, and immunogenicity of heterologous two-dose vaccination regimens using Ad26.ZEBOV and MVA-BN-Filo, in healthy adults in Africa. Accelerated implementation strategies are hereby presented.

Strategies included holding the African Vaccine Regulatory Forum (AVAREF) joint review meeting; expedited review by institutional ethics and country-specific regulatory bodies; competitive recruitment between sites; electronic data capture (EDC); frequent study monitoring schedule; involvement of a community advisory board (CAB); and utilization of a 'phased' study information-sharing approach in community engagement and participant recruitment.